Sequence of COBT_SALTY
EC Number:2.4.2.21
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
Q05603
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
356
36613
Reaction
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+
Other sequences found for EC No. 2.4.2.21
General information:
Sequence
0 MQTLHALLRD IPAPDAEAMA RAQQHIDGLL KPPGSLGRLE TLAVQLAGMP GLNGTPQVGE
60 KAVLVMCADH GVWDEGVAVS PKIVTAIQAA NMTRGTTGVC VLAAQAGAKV HVIDVGIDAE
120 PIPGVVNMRV ARGCGNIAVG PAMSRLQAEA LLLEVSRYTC DLAQRGVTLF GVGELGMANT
180 TPAAAMVSVF TGSDAKEVVG IGANLPPSRI DNKVDVVRRA IAINQPNPRD GIDVLSKVGG
240 FDLVGMTGVM LGAARCGLPV LLDGFLSYSA ALAACQIAPA VRPYLIPSHF SAEKGARIAL
300 AHLSMEPYLH MAMRLGEGSG AALAMPIVEA ACAMFHNMGE LAASNIVLPE GNANAT
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
146704
Chen P.,Ailion M.,Weyand N.,Roth J.R.
The end of the cob operon: evidence that the last gene (cobT) catalyzes synthesis of the lower ligand of vitamin B12, dimethylbenzimidazole.
J. Bacteriol.
177
1461-1469
1995
146705
McClelland M.,Sanderson K.E.,Spieth J.,Clifton S.W.,Latreille P.,Courtney L.,Porwollik S.,Ali J.,Dante M.,Du F.,Hou S.,Layman D.,Leonard S.,Nguyen C.,Scott K.,Holmes A.,Grewal N.,Mulvaney E.,Ryan E.,Sun H.,Florea L.,Miller W.,Stoneking T.,Nhan M.,Waterston R.,Wilson R.K.
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
Nature
413
852-856
2001
146706
Roth J.R.,Lawrence J.G.,Rubenfield M.,Kieffer-Higgins S.,Church G.M.
Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.
J. Bacteriol.
175
3303-3316
1993
146707
Trzebiatowski J.R.,O'Toole G.A.,Escalante-Semerena J.C.
The cobT gene of Salmonella typhimurium encodes the NaMN: 5,6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole, an intermediate in the synthesis of the nucleotide loop of cobalamin.
J. Bacteriol.
176
3568-3575
1994
146708
Cheong C.-G.,Escalante-Semerena J.C.,Rayment I.
The three-dimensional structures of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9-A resolution.
Biochemistry
38
16125-16135
1999
146709
Cheong C.G.,Escalante-Semerena J.C.,Rayment I.
Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica.
J. Biol. Chem.
276
37612-37620
2001
146711
Chan C.H.,Newmister S.A.,Talyor K.,Claas K.R.,Rayment I.,Escalante-Semerena J.C.
Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.
Biochim. Biophys. Acta
1840
464-475
2014
