Sequence of ERYA1_SACER
EC Number:1.1.1.100
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
Other sequences found for EC No. 1.1.1.100
EC Number:2.3.1.94
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ = 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
Other sequences found for EC No. 2.3.1.94
General information:
Sequence
0 MSGPRSRTTS RRTPVRIGAV VVASSTSELL DGLAAVADGR PHASVVRGVA RPSAPVVFVF
60 PGQGAQWAGM AGELLGESRV FAAAMDACAR AFEPVTDWTL AQVLDSPEQS RRVEVVQPAL
120 FAVQTSLAAL WRSFGVTPDA VVGHSIGELA AAHVCGAAGA ADAARAAALW SREMIPLVGN
180 GDMAAVALSA DEIEPRIARW DDDVVLAGVN GPRSVLLTGS PEPVARRVQE LSAEGVRAQV
240 INVSMAAHSA QVDDIAEGMR SALAWFAPGG SEVPFYASLT GGAVDTRELV ADYWRRSFRL
300 PVRFDEAIRS ALEVGPGTFV EASPHPVLAA ALQQTLDAEG SSAAVVPTLQ RGQGGMRRFL
360 LAAAQAFTGG VAVDWTAAYD DVGPNPALCR SSRRPRRKTS RPSPASTGTR HRTCCERLLA
420 VVNGETAALA GREADAEATF RELGLDSVLA AQLRAKVSAA IGREVNIALL YDHPTPRALA
480 EALAAGTEVA QRETRARTNE AAPGEPVAVV AMACRLPGGV STPEEFWELL SEGRDAVAGL
540 PTDRGWDLDS LFHPDPTRSG TAHQRGGGFL TEATAFDPAF FGMSPREALA VDPQQRLMLE
600 LSWEVLERAG IPPTSLQASP TGVFVGLIPQ EYGPRLAEGG EGVEGYLMTG TTTSVASGRI
660 AYTLGLEGPA ISVDTACSSS LVAVHLACQS LRRGESSLAM AGGVTVMPTP GMLVDFSRMN
720 SLAPDGRCKA FSAGANGFGM AEGAGMLLLE RLSDARRNGH PVLAVLRGTA VNSDGASNGL
780 SAPNGRAQVR VIQQALAESG LGPADIDAVE AHGTGTRLGD PIEARALFEA YGRDREQPLH
840 LGSVKSNLGH TQAAAGVAGV IKMVLAMRAG TLPRTLHASE RSKEIDWSSG AISLLDEPEP
900 WPAGARPRRA GVSSFGISGT NAHAIIEEAP QVVEGERVEA GDVVAPWVLS ASSAEGLRAQ
960 AARLAAHLRE HPGQDPRDIA YSLATGRAAL PHRAAFAPVD ESAALRVLDG LATGNADGAA
1020 VGTSRAQQRA VFVFPGQGWQ WAGMAVDLLD TSPVFAAALR ECADALEPHL DFEVIPFLRA
1080 EAARREQDAA LSTERVDVVQ PVMFAVMVSL ASMWRAHGVE PAAVIGHSQG EIAAACVAGA
1140 LSLDDAARVV ALRSRVIATM PGNKGMASIA APAGEVRARI GDRVEIAAVN GPRSVVVAGD
1200 SDELDRLVAS CTTECIRAKR LAVDYASHSS HVETIRDALH AELGEDFHPL PGFVPFFSTV
1260 TGRWTQPDEL DAGYWYRNLR RTVRFADAVR ALAEQGYRTF LEVSAHPILT AAIEEIGDGS
1320 GADLSAIHSL RRGDGSLADF GEALSRAFAA GVAVDWESVH LGTGARRVPL PTYPFQRERV
1380 WLEPKPVARR STEVDEVSAL RYRIEWRPTG AGEPARLDGT WLVAKYAGTA DETSTAAREA
1440 LESAGARVRE LVVDARCGRD ELAERLRSVG EVAGVLSLLA VDEAEPEEAP LALASLADTL
1500 SLVQAMVSAE LGCPLWTVTE SAVATGPFER VRNAAHGALW GVGRVIALEN PAVWGGLVDV
1560 PAGSVAELAR HLAAVVSGGA GEDQLALRAD GVYGRRWVRA AAPATDDEWK PTGTVLVTGG
1620 TGGVGGQIAR WLARRGAPHL LLVSRSGPDA DGAGELVAEL EALGARTTVA ACDVTDRESV
1680 RELLGGIGDD VPLSAVFHAA ATLDDGTVDT LTGERIERAS RAKVLGARNL HELTRELDLT
1740 AFVLFSSFAS AFGAPGLGGY APGNAYLDGL AQQRRSDGLP ATAVAWGTWA GSGMAEGAVA
1800 DRFRRHGVIE MPPETACRAL QNALDRAEVC PIVIDVRWDR FLLAYTAQRP TRLFDEIDDA
1860 RRAAPQAPAE PRVGALASLP APEREEALFE LVRSHAAAVL GHASAERVPA DQAFAELGVD
1920 SLSALELRNR LGAATGVRLP TTTVFDHPDV RTLAAHLAAE LGGATGAEQA APATTAPVDE
1980 PIAIVGMACR LPGEVDSPER LWELITSGRD SAAEVPDDRG WVPDELMASD AAGTRAHGNF
2040 MAGAGDFDAA FFGISPREAL AMDPQQRQAL ETTWEALESA GIPPETLRGS DTGVFVGMSH
2100 QGYATGRPRP EDGVDGYLLT GNTASVASGR IAYVLGLEGP ALTVDTACSS SLVALHTACG
2160 SLRDGDCGLA VAGGVSVMAG PEVFTEFSRQ GALSPDGRCK PFSDEADGFG LGEGSAFVVL
2220 QRLSDARREG RRVLGVVAGS AVNQDGASNG LSAPSGVAQQ RVIRRAWARA GITGADVAVV
2280 EAHGTGTRLG DPVEASALLA TYGKSRGSSG PVLLGSVKSN IGHAQAAAGV AGVIKVLLGL
2340 ERGVVPPMLC RGERSGLIDW SSGEIELADG VREWSPAADG VRRAGVSAFG VSGTNAHVII
2400 AEPPEPEPVP QPRRMLPATG VVPVVLSART GAALRAQAGR LADHLAAHPG IAPADVSWTM
2460 ARARQHFEER AAVLAADTAE AVHRLRAVAD GAVVPGVVTG SASDGGSVFV FPGQGAQWEG
2520 MARELLPVPV FAESIAECDA VLSEVAGFSV SEVLEPRPDA PSLERVDVVQ PVLFAVMVSL
2580 ARLWRACGAV PSAVIGHSQG EIAAAVVAGA LSLEDGMRVV ARRSRAVRAV AGRGSMLSVR
2640 GGRSDVEKLL ADDSWTGRLE VAAVNGPDAV VVAGDAQAAR EFLEYCEGVG IRARAIPVDY
2700 ASHTAHVEPV RDELVQALAG ITPRRAEVPF FSTLTGDFLD GTELDAGYWY RNLRHPVEFH
2760 SAVQALTDQG YATFIEVSPH PVLASSVQET LDDAESDAAV LGTLERDAGD ADRFLTALAD
2820 AHTRGVAVDW EAVLGRAGLV DLPGYPFQGK RFWLLPDRTT PRDELDGWFY RVDWTEVPRS
2880 EPAALRGRWL VVVPEGHEED GWTVEVRSAL AEAGAEPEVT RGVGGLVGDC AGVVSLLALE
2940 GDGAVQTLVL VRELDAEGID APLWTVTFGA VDAGSPVARP DQAKLWGLGQ VASLERGPRW
3000 TGLVDLPHMP DPELRGRLTA VLAGSEDQVA VRADAVRARR LSPAHVTATS EYAVPGGTIL
3060 VTGGTAGLGA EVARWLAGRG AEHLALVSRR GPDTEGVGDL TAELTRLGAR VSVHACDVSS
3120 REPVRELVHG LIEQGDVVRG VVHAAGLPQQ VAINDMDEAA FDEVVAAKAG GAVHLDELCS
3180 DAELFLLFSS GAGVWGSARQ GAYAAGNAFL DAFARHRRGR GLPATSVAWG LWAAGGMTGD
3240 EEAVSFLRER GVRAMPVPRA LAALDRVLAS GETAVVVTDV DWPAFAESYT AARPRPLLDR
3300 IVTTAPSERA GEPETESLRD RLAGLPRAER TAELVRLVRT STATVLGHDD PKAVRATTPF
3360 KELGFDSLAA VRLRNLLNAA TGLRLPSTLV FDHPNASAVA GFLDAELGTE VRGEAPSALA
3420 GLDALEGALP EVPATEREEL VQRLERMLAA LRPVAQAADA SGTGANPSGD DLGEAGVDEL
3480 LEALGRELDG D
Download this sequence
in fasta formatDownload all sequences for 2.3.1.94
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
795889
Donadio S.,Staver M.J.,McAlpine J.B.,Swanson S.J.,Katz L.
Modular organization of genes required for complex polyketide biosynthesis.
Science
252
675-679
1991
795890
Donadio S.,Staver M.J.
IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea.
Gene
126
147-151
1993
795891
Caffrey P.,Bevitt D.J.,Staunton J.,Leadlay P.F.
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.
FEBS Lett.
304
225-228
1992
795892
Khosla C.,Tang Y.,Chen A.Y.,Schnarr N.A.,Cane D.E.
Structure and mechanism of the 6-deoxyerythronolide B synthase.
Annu. Rev. Biochem.
76
195-221
2007
795893
Zhang H.,Wang Y.,Wu J.,Skalina K.,Pfeifer B.A.
Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host.
Chem. Biol.
17
1232-1240
2010
795894
Keatinge-Clay A.T.,Stroud R.M.
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.
Structure
14
737-748
2006
795895
Alekseyev V.Y.,Liu C.W.,Cane D.E.,Puglisi J.D.,Khosla C.
Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.
Protein Sci.
16
2093-2107
2007
