Any feedback?
Please rate this page
(sequences.php)
(0/150)

BRENDA support

Sequence of CP4AB_HUMAN

EC Number:1.14.14.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
unspecific monooxygenase
Q02928
Homo sapiens
519
59348
Reaction
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.1

EC Number:1.14.14.80

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
long-chain fatty acid omega-monooxygenase
Q02928
Homo sapiens
519
59348
Reaction
a long-chain fatty acid + [reduced NADPH-hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.80

General information:

Sequence
show sequence in fasta format
  0 MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ FPCPPSHWLF
 60 GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY DPDYMKVILG RSDPKSHGSY
120 RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF HYDILKPYVG LMADSVRVML DKWEELLGQD
180 SPLEVFQHVS LMTLDTIMKC AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND
240 TIYSLTSAGR WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM
300 ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE IHSLLGDGAS
360 ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP DGRSLPKGIM VLLSIYGLHH
420 NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF SGGSRNCIGK QFAMNELKVA TALTLLRFEL
480 LPDPTRIPIP IARLVLKSKN GIHLRLRRLP NPCEDKDQL
Download this sequence
in fasta format
Download all sequences for 1.14.14.80
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
20418
Palmer C.N.A.,Richardson T.H.,Griffin K.J.,Hsu M.-H.,Muerhoff A.S.,Clark J.E.,Johnson E.F.
Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli.
Biochim. Biophys. Acta
1172
161-166
1993
20419
Kawashima H.,Kusunose E.,Kikuta Y.,Kinoshita H.,Tanaka S.,Yamamoto S.,Kishimoto T.,Kusunose M.
Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase.
J. Biochem.
116
74-80
1994
20420
Imaoka S.,Ogawa H.,Kimura S.,Gonzalez F.J.
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney.
DNA Cell Biol.
12
893-899
1993
20421
Bellamine A.,Wang Y.,Waterman M.R.,Gainer J.V. III,Dawson E.P.,Brown N.J.,Capdevila J.H.
Characterization of the CYP4A11 gene, a second CYP4A gene in humans.
Arch. Biochem. Biophys.
409
221-227
2003
20423
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
20424
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
20425
Kawashima H.,Kusunose E.,Kubota I.,Maekawa M.,Kusunose M.
Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases.
Biochim. Biophys. Acta
1123
156-162
1992
20426
Bell D.R.,Plant N.J.,Rider C.G.,Na L.,Brown S.,Ateitalla I.,Acharya S.K.,Davies M.H.,Elias E.E.,Jenkins N.A.,Gilbert D.J.,Copeland N.G.,Elcombe C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.
Biochem. J.
294
173-180
1993
20427
Powell P.K.,Wolf I.,Lasker J.M.
Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes.
Arch. Biochem. Biophys.
335
219-226
1996
20428
Adas F.,Salauen J.P.,Berthou F.,Picart D.,Simon B.,Amet Y.
Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.
J. Lipid Res.
40
1990-1997
1999
20429
Hoch U.,Zhang Z.,Kroetz D.L.,Ortiz de Montellano P.R.
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.
Arch. Biochem. Biophys.
373
63-71
2000
20430
Lasker J.M.,Chen W.B.,Wolf I.,Bloswick B.P.,Wilson P.D.,Powell P.K.
Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11.
J. Biol. Chem.
275
4118-4126
2000
20431
Hoch U.,Ortiz de Montellano P.R.
Covalently linked heme in cytochrome P4504A fatty acid hydroxylases.
J. Biol. Chem.
276
11339-11346
2001
20432
LeBrun L.A.,Hoch U.,Ortiz de Montellano P.R.
Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.
J. Biol. Chem.
277
12755-12761
2002
20433
Le Quere V.,Plee-Gautier E.,Potin P.,Madec S.,Salauen J.P.
Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.
J. Lipid Res.
45
1446-1458
2004
20434
Gainer J.V.,Bellamine A.,Dawson E.P.,Womble K.E.,Grant S.W.,Wang Y.,Cupples L.A.,Guo C.-Y.,Demissie S.,O'Donnell C.J.,Brown N.J.,Waterman M.R.,Capdevila J.H.
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Circulation
111
63-69
2005
20435
Sanders R.J.,Ofman R.,Dacremont G.,Wanders R.J.,Kemp S.
Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
FASEB J.
22
2064-2071
2008
20436
Dhar M.,Sepkovic D.W.,Hirani V.,Magnusson R.P.,Lasker J.M.
Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.
J. Lipid Res.
49
612-624
2008
20437
Cho B.H.,Park B.L.,Kim L.H.,Chung H.S.,Shin H.D.
Highly polymorphic human CYP4A11 gene.
J. Hum. Genet.
50
259-263
2005