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Sequence of DPRE2_MYCTU

EC Number:1.1.1.333

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
P9WGS9
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
254
27469
Reaction
trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+
Other sequences found for EC No. 1.1.1.333

General information:

Sequence
show sequence in fasta format
  0 MVLDAVGNPQ TVLLLGGTSE IGLAICERYL HNSAARIVLA CLPDDPRRED AAAAMKQAGA
 60 RSVELIDFDA LDTDSHPKMI EAAFSGGDVD VAIVAFGLLG DAEELWQNQR KAVQIAEINY
120 TAAVSVGVLL AEKMRAQGFG QIIAMSSAAG ERVRRANFVY GSTKAGLDGF YLGLSEALRE
180 YGVRVLVIRP GQVRTRMSAH LKEAPLTVDK EYVANLAVTA SAKGKELVWA PAAFRYVMMV
240 LRHIPRSIFR KLPI
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
664740
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
664741
Sassetti C.M.,Boyd D.H.,Rubin E.J.
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol. Microbiol.
48
77-84
2003
664742
Mikusova K.,Huang H.,Yagi T.,Holsters M.,Vereecke D.,D'Haeze W.,Scherman M.S.,Brennan P.J.,McNeil M.R.,Crick D.C.
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.
J. Bacteriol.
187
8020-8025
2005
664743
Raman K.,Yeturu K.,Chandra N.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
BMC Syst. Biol.
2
109-109
2008
664744
Makarov V.,Manina G.,Mikusova K.,Mollmann U.,Ryabova O.,Saint-Joanis B.,Dhar N.,Pasca M.R.,Buroni S.,Lucarelli A.P.,Milano A.,De Rossi E.,Belanova M.,Bobovska A.,Dianiskova P.,Kordulakova J.,Sala C.,Fullam E.,Schneider P.,McKinney J.D.,Brodin P.,Christophe T.,Waddell S.,Butcher P.,Albrethsen J.,Rosenkrands I.,Brosch R.,Nandi V.,Bharath S.,Gaonkar S.,Shandil R.K.,Balasubramanian V.,Balganesh T.,Tyagi S.,Grosset J.,Riccardi G.,Cole S.T.
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.
Science
324
801-804
2009
664745
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
664746
Batt S.M.,Jabeen T.,Bhowruth V.,Quill L.,Lund P.A.,Eggeling L.,Alderwick L.J.,Futterer K.,Besra G.S.
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proc. Natl. Acad. Sci. U.S.A.
109
11354-11359
2012
664747
Kolly G.S.,Boldrin F.,Sala C.,Dhar N.,Hartkoorn R.C.,Ventura M.,Serafini A.,McKinney J.D.,Manganelli R.,Cole S.T.
Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.
Mol. Microbiol.
92
194-211
2014
664748
Brecik M.,Centarova I.,Mukherjee R.,Kolly G.S.,Huszar S.,Bobovska A.,Kilacskova E.,Mokosova V.,Svetlikova Z.,Sarkan M.,Neres J.,Kordulakova J.,Cole S.T.,Mikusova K.
DprE1 is a vulnerable tuberculosis drug target due to its cell wall localization.
ACS Chem. Biol.
10
1631-1636
2015
664749
Bhutani I.,Loharch S.,Gupta P.,Madathil R.,Parkesh R.
Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies.
PLoS ONE
10
0-0
2015