Sequence of FAAH1_RAT
EC Number:3.5.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.5.1
EC Number:3.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.1
EC Number:3.5.1.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a monocarboxylic acid amide + H2O = a monocarboxylate + NH3
Other sequences found for EC No. 3.5.1.4
EC Number:3.5.1.99
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
anandamide + H2O = arachidonic acid + ethanolamine
Other sequences found for EC No. 3.5.1.99
General information:
Sequence
0 MVLSEVWTTL SGVSGVCLAC SLLSAAVVLR WTGRQKARGA ATRARQKQRA SLETMDKAVQ
60 RFRLQNPDLD SEALLTLPLL QLVQKLQSGE LSPEAVFFTY LGKAWEVNKG TNCVTSYLTD
120 CETQLSQAPR QGLLYGVPVS LKECFSYKGH DSTLGLSLNE GMPSESDCVV VQVLKLQGAV
180 PFVHTNVPQS MLSFDCSNPL FGQTMNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG
240 SIRFPSAFCG ICGLKPTGNR LSKSGLKGCV YGQTAVQLSL GPMARDVESL ALCLKALLCE
300 HLFTLDPTVP PLPFREEVYR SSRPLRVGYY ETDNYTMPSP AMRRALIETK QRLEAAGHTL
360 IPFLPNNIPY ALEVLSAGGL FSDGGRSFLQ NFKGDFVDPC LGDLILILRL PSWFKRLLSL
420 LLKPLFPRLA AFLNSMRPRS AEKLWKLQHE IEMYRQSVIA QWKAMNLDVL LTPMLGPALD
480 LNTPGRATGA ISYTVLYNCL DFPAGVVPVT TVTAEDDAQM ELYKGYFGDI WDIILKKAMK
540 NSVGLPVAVQ CVALPWQEEL CLRFMREVEQ LMTPQKQPS
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in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1185219
Cravatt B.F.,Giang D.K.,Mayfield S.P.,Boger D.L.,Lerner R.A.,Gilula N.B.
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides.
Nature
384
83-87
1996
1185220
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1185221
Giang D.K.,Cravatt B.F.
Molecular characterization of human and mouse fatty acid amide hydrolases.
Proc. Natl. Acad. Sci. U.S.A.
94
2238-2242
1997
1185222
Thomas E.A.,Cravatt B.F.,Danielson P.E.,Gilula N.B.,Sutcliffe J.G.
Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system.
J. Neurosci. Res.
50
1047-1052
1997
1185223
Kurahashi Y.,Ueda N.,Suzuki H.,Suzuki M.,Yamamoto S.
Reversible hydrolysis and synthesis of anandamide demonstrated by recombinant rat fatty-acid amide hydrolase.
Biochem. Biophys. Res. Commun.
237
512-515
1997
1185224
Patricelli M.P.,Lashuel H.A.,Giang D.K.,Kelly J.W.,Cravatt B.F.
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.
Biochemistry
37
15177-15187
1998
1185225
Goparaju S.K.,Kurahashi Y.,Suzuki H.,Ueda N.,Yamamoto S.
Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis.
Biochim. Biophys. Acta
1441
77-84
1999
1185226
Boger D.L.,Fecik R.A.,Patterson J.E.,Miyauchi H.,Patricelli M.P.,Cravatt B.F.
Fatty acid amide hydrolase substrate specificity.
Bioorg. Med. Chem. Lett.
10
2613-2616
2000
1185227
McKinney M.K.,Cravatt B.F.
Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase.
J. Biol. Chem.
278
37393-37399
2003
1185228
Saghatelian A.,Trauger S.A.,Want E.J.,Hawkins E.G.,Siuzdak G.,Cravatt B.F.
Assignment of endogenous substrates to enzymes by global metabolite profiling.
Biochemistry
43
14332-14339
2004
1185229
Vila A.,Rosengarth A.,Piomelli D.,Cravatt B.,Marnett L.J.
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase.
Biochemistry
46
9578-9585
2007
1185230
Bracey M.H.,Hanson M.A.,Masuda K.R.,Stevens R.C.,Cravatt B.F.
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science
298
1793-1796
2002
1185231
Mileni M.,Johnson D.S.,Wang Z.,Everdeen D.S.,Liimatta M.,Pabst B.,Bhattacharya K.,Nugent R.A.,Kamtekar S.,Cravatt B.F.,Ahn K.,Stevens R.C.
Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
Proc. Natl. Acad. Sci. U.S.A.
105
12820-12824
2008
