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Sequence of AFLH_ASPPU

EC Number:1.1.1.352

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
5'-hydroxyaverantin dehydrogenase
P87017
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
278
29557
Reaction
(1'S,5'R)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH + H+
Other sequences found for EC No. 1.1.1.352

General information:

Sequence
show sequence in fasta format
  0 MEVLDTTVDL GTLQGKSALI TGGASGIGLA TARAWAAAGM YVTIADIQPL ETGQNILADL
 60 AGGHVHYVCC DVTSWESQIT AFKEAIQFTP SKALDIVAAF AGVSFAGGNQ VDHVLAAGDP
120 RLDVNPSPPD IRNIQVNLIG VYYTSWLGLY YLRLSPTNKA ANPSPDKSLI LMGSIGSYMD
180 SPKASTYPAS KFGVRGLFRS TRARTRELGV RCNLLAPWFI DTPLIAPMKK AMAARGIDMA
240 QRLTFASVDA CVEAATTCAA NPQLHGTPPI RYAYCLKT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1154758
Chang P.K.,Yu J.,Ehrlich K.C.,Boue S.M.,Montalbano B.G.,Bhatnagar D.,Cleveland T.E.
adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin.
Appl. Environ. Microbiol.
66
4715-4719
2000
1154759
Yu J.,Bhatnagar D.,Cleveland T.E.
Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus.
FEBS Lett.
564
126-130
2004
1154761
Sakuno E.,Yabe K.,Nakajima H.
Involvement of two cytosolic enzymes and a novel intermediate, 5'-oxoaverantin, in the pathway from 5'-hydroxyaverantin to averufin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
69
6418-6426
2003
1154762
Skory C.D.,Chang P.K.,Cary J.,Linz J.E.
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
58
3527-3537
1992
1154763
Keller N.P.,Dischinger H.C. Jr.,Bhatnager D.,Cleveland T.E.,Ullah A.H.J.
Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway.
Appl. Environ. Microbiol.
59
479-484
1993
1154764
Yabe K.,Matsuyama Y.,Ando Y.,Nakajima H.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
Appl. Environ. Microbiol.
59
2486-2492
1993
1154765
Yabe K.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate.
Appl. Environ. Microbiol.
59
2493-2500
1993
1154766
Motomura M.,Chihaya N.,Shinozawa T.,Hamasaki T.,Yabe K.
Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
65
4987-4994
1999
1154767
Zhou R.,Linz J.E.
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
Appl. Environ. Microbiol.
65
5639-5641
1999
1154768
Hitchman T.S.,Schmidt E.W.,Trail F.,Rarick M.D.,Linz J.E.,Townsend C.A.
Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis.
Bioorg. Chem.
29
293-307
2001
1154769
Udwary D.W.,Casillas L.K.,Townsend C.A.
Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis.
J. Am. Chem. Soc.
124
5294-5303
2002
1154770
Yu J.,Chang P.K.,Ehrlich K.C.,Cary J.W.,Bhatnagar D.,Cleveland T.E.,Payne G.A.,Linz J.E.,Woloshuk C.P.,Bennett J.W.
Clustered pathway genes in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
70
1253-1262
2004
1154771
Ehrlich K.C.,Chang P.K.,Yu J.,Cotty P.J.
Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation.
Appl. Environ. Microbiol.
70
6518-6524
2004
1154772
Sakuno E.,Wen Y.,Hatabayashi H.,Arai H.,Aoki C.,Yabe K.,Nakajima H.
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
71
2999-3006
2005
1154773
Ehrlich K.C.,Montalbano B.,Boue S.M.,Bhatnagar D.
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
Appl. Environ. Microbiol.
71
8963-8965
2005
1154774
Henry K.M.,Townsend C.A.
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites.
J. Am. Chem. Soc.
127
3724-3733
2005
1154775
Cary J.W.,Ehrlich K.C.,Bland J.M.,Montalbano B.G.
The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.
Appl. Environ. Microbiol.
72
1096-1101
2006
1154776
Cai J.,Zeng H.,Shima Y.,Hatabayashi H.,Nakagawa H.,Ito Y.,Adachi Y.,Nakajima H.,Yabe K.
Involvement of the nadA gene in formation of G-group aflatoxins in Aspergillus parasiticus.
Fungal Genet. Biol.
45
1081-1093
2008
1154777
Crawford J.M.,Thomas P.M.,Scheerer J.R.,Vagstad A.L.,Kelleher N.L.,Townsend C.A.
Deconstruction of iterative multidomain polyketide synthase function.
Science
320
243-246
2008