Sequence of ARGI2_HUMAN
EC Number:3.5.3.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-arginine + H2O = L-ornithine + urea
Other sequences found for EC No. 3.5.3.1
General information:
Sequence
0 MSLRGSLSRL LQTRVHSILK KSVHSVAVIG APFSQGQKRK GVEHGPAAIR EAGLMKRLSS
60 LGCHLKDFGD LSFTPVPKDD LYNNLIVNPR SVGLANQELA EVVSRAVSDG YSCVTLGGDH
120 SLAIGTISGH ARHCPDLCVV WVDAHADINT PLTTSSGNLH GQPVSFLLRE LQDKVPQLPG
180 FSWIKPCISS ASIVYIGLRD VDPPEHFILK NYDIQYFSMR DIDRLGIQKV MERTFDLLIG
240 KRQRPIHLSF DIDAFDPTLA PATGTPVVGG LTYREGMYIA EEIHNTGLLS ALDLVEVNPQ
300 LATSEEEAKT TANLAVDVIA SSFGQTREGG HIVYDQLPTP SSPDESENQA RVRI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
769500
Gotoh T.,Sonoki T.,Nagasaki A.,Terada K.,Takiguchi M.,Mori M.
Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line.
FEBS Lett.
395
119-122
1996
769501
Vockley J.G.,Jenkinson C.P.,Shukla H.,Kern R.M.,Grody W.W.,Cederbaum S.D.
Cloning and characterization of the human type II arginase gene.
Genomics
38
118-123
1996
769502
Morris S.M. Jr.,Bhamidipati D.,Kepka-Lenhart D.
Human type II arginase: sequence analysis and tissue-specific expression.
Gene
193
157-161
1997
769505
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
769507
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
769508
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
769509
Yepuri G.,Velagapudi S.,Xiong Y.,Rajapakse A.G.,Montani J.P.,Ming X.F.,Yang Z.
Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging.
Aging Cell
11
1005-1016
2012
769510
Xiong Y.,Yu Y.,Montani J.P.,Yang Z.,Ming X.F.
Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability.
J. Am. Heart Assoc.
2
0-0
2013
769511
Xiong Y.,Yepuri G.,Forbiteh M.,Yu Y.,Montani J.P.,Yang Z.,Ming X.F.
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.
Autophagy
10
2223-2238
2014
769512
Geiger R.,Rieckmann J.C.,Wolf T.,Basso C.,Feng Y.,Fuhrer T.,Kogadeeva M.,Picotti P.,Meissner F.,Mann M.,Zamboni N.,Sallusto F.,Lanzavecchia A.
L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity.
Cell
167
829-842
2016
769513
Xu W.,Ghosh S.,Comhair S.A.,Asosingh K.,Janocha A.J.,Mavrakis D.A.,Bennett C.D.,Gruca L.L.,Graham B.B.,Queisser K.A.,Kao C.C.,Wedes S.H.,Petrich J.M.,Tuder R.M.,Kalhan S.C.,Erzurum S.C.
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
J. Clin. Invest.
126
2465-2481
2016
769514
McGovern N.,Shin A.,Low G.,Low D.,Duan K.,Yao L.J.,Msallam R.,Low I.,Shadan N.B.,Sumatoh H.R.,Soon E.,Lum J.,Mok E.,Hubert S.,See P.,Kunxiang E.H.,Lee Y.H.,Janela B.,Choolani M.,Mattar C.N.Z.,Fan Y.,Lim T.K.H.,Chan D.K.H.,Tan K.K.,Tam J.K.C.,Schuster C.,Elbe-Buerger A.,Wang X.N.,Bigley V.,Collin M.,Haniffa M.,Schlitzer A.,Poidinger M.,Albani S.,Larbi A.,Newell E.W.,Chan J.K.Y.,Ginhoux F.
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
Nature
546
662-666
2017
769515
Cama E.,Colleluori D.M.,Emig F.A.,Shin H.,Kim S.W.,Kim N.N.,Traish A.M.,Ash D.E.,Christianson D.W.
Human arginase II: crystal structure and physiological role in male and female sexual arousal.
Biochemistry
42
8445-8451
2003
