Sequence of HDAC2_MOUSE
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA
60 TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA
120 GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH
180 GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ
240 IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVAK TFNLPLLMLG
300 GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM
360 EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE
420 FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDPKGA
480 KSEQLSNP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1067484
Yang W.-M.,Inouye C.J.,Zeng Y.,Bearss D.,Seto E.
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
Proc. Natl. Acad. Sci. U.S.A.
93
12845-12850
1996
1067486
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1067487
Laherty C.D.,Billin A.N.,Lavinsky R.M.,Yochum G.S.,Bush A.C.,Sun J.-M.,Mullen T.-M.,Davie J.R.,Rose D.W.,Glass C.K.,Rosenfeld M.G.,Ayer D.E.,Eisenman R.N.
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
Mol. Cell
2
33-42
1998
1067488
Downes M.,Ordentlich P.,Kao H.-Y.,Alvarez J.G.A.,Evans R.M.
Identification of a nuclear domain with deacetylase activity.
Proc. Natl. Acad. Sci. U.S.A.
97
10330-10335
2000
1067489
Amann J.M.,Nip J.,Strom D.K.,Lutterbach B.,Harada H.,Lenny N.,Downing J.R.,Meyers S.,Hiebert S.W.
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Mol. Cell. Biol.
21
6470-6483
2001
1067490
Vaute O.,Nicolas E.,Vandel L.,Trouche D.
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.
Nucleic Acids Res.
30
475-481
2002
1067491
Yang L.,Mei Q.,Zielinska-Kwiatkowska A.,Matsui Y.,Blackburn M.L.,Benedetti D.,Krumm A.A.,Taborsky G.J. Jr.,Chansky H.A.
An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.
Biochem. J.
369
651-657
2003
1067492
Naruse Y.,Oh-hashi K.,Iijima N.,Naruse M.,Yoshioka H.,Tanaka M.
Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation.
Mol. Cell. Biol.
24
6278-6287
2004
1067493
Chakravarthy S.,Gundimella S.K.,Caron C.,Perche P.-Y.,Pehrson J.R.,Khochbin S.,Luger K.
Structural characterization of the histone variant macroH2A.
Mol. Cell. Biol.
25
7616-7624
2005
1067494
Davis C.A.,Haberland M.,Arnold M.A.,Sutherland L.B.,McDonald O.G.,Richardson J.A.,Childs G.,Harris S.,Owens G.K.,Olson E.N.
PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.
Mol. Cell. Biol.
26
2626-2636
2006
1067495
Saleque S.,Kim J.,Rooke H.M.,Orkin S.H.
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.
Mol. Cell
27
562-572
2007
1067496
Manavathi B.,Peng S.,Rayala S.K.,Talukder A.H.,Wang M.H.,Wang R.A.,Balasenthil S.,Agarwal N.,Frishman L.J.,Kumar R.
Repression of Six3 by a corepressor regulates rhodopsin expression.
Proc. Natl. Acad. Sci. U.S.A.
104
13128-13133
2007
1067497
Villen J.,Beausoleil S.A.,Gerber S.A.,Gygi S.P.
Large-scale phosphorylation analysis of mouse liver.
Proc. Natl. Acad. Sci. U.S.A.
104
1488-1493
2007
1067498
Nott A.,Watson P.M.,Robinson J.D.,Crepaldi L.,Riccio A.
S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons.
Nature
455
411-415
2008
1067499
Trost M.,English L.,Lemieux S.,Courcelles M.,Desjardins M.,Thibault P.
The phagosomal proteome in interferon-gamma-activated macrophages.
Immunity
30
143-154
2009
1067500
Sweet S.M.,Bailey C.M.,Cunningham D.L.,Heath J.K.,Cooper H.J.
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Mol. Cell. Proteomics
8
904-912
2009
1067501
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
1067502
Li D.Q.,Pakala S.B.,Reddy S.D.,Ohshiro K.,Peng S.H.,Lian Y.,Fu S.W.,Kumar R.
Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway.
J. Biol. Chem.
285
10044-10052
2010
1067503
Pakala S.B.,Bui-Nguyen T.M.,Reddy S.D.,Li D.Q.,Peng S.,Rayala S.K.,Behringer R.R.,Kumar R.
Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis.
J. Biol. Chem.
285
23590-23597
2010
1067504
Pakala S.B.,Bui-Nguyen T.M.,Reddy S.D.,Li D.Q.,Peng S.,Rayala S.K.,Behringer R.R.,Kumar R.
J. Biol. Chem.
292
4764-4764
2017
1067505
Kornberg M.D.,Sen N.,Hara M.R.,Juluri K.R.,Nguyen J.V.,Snowman A.M.,Law L.,Hester L.D.,Snyder S.H.
GAPDH mediates nitrosylation of nuclear proteins.
Nat. Cell Biol.
12
1094-1100
2010
1067506
He Z.,Cai J.,Lim J.W.,Kroll K.,Ma L.
A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.
J. Biol. Chem.
286
7279-7289
2011
1067507
Huang G.J.,He Z.,Ma L.
ZFP932 suppresses cellular Hedgehog response and Patched1 transcription.
Vitam. Horm.
88
309-332
2012
1067508
Welcker J.E.,Hernandez-Miranda L.R.,Paul F.E.,Jia S.,Ivanov A.,Selbach M.,Birchmeier C.
Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.
Development
140
4947-4958
2013
1067509
Yan L.,Jin W.,Zhao Q.,Cui X.,Shi T.,Xu Y.,Li F.,Jin W.,Zhang Z.,Zhang Z.,Tang Q.Q.,Pan D.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Adv. Sci.
8
0-0
2021
1067510
Kelly R.D.W.,Chandru A.,Watson P.J.,Song Y.,Blades M.,Robertson N.S.,Jamieson A.G.,Schwabe J.W.R.,Cowley S.M.
Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.
Sci. Rep.
8
14690-14690
2018
