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Sequence of DGKQ_HUMAN

EC Number:2.7.1.107

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
diacylglycerol kinase (ATP)
P52824
Homo sapiens
942
101155
Reaction
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
Other sequences found for EC No. 2.7.1.107

General information:

Sequence
show sequence in fasta format
  0 MAAAAEPGAR AWLGGGSPRP GSPACSPVLG SGGRARPGPG PGPGPERAGV RAPGPAAAPG
 60 HSFRKVTLTK PTFCHLCSDF IWGLAGFLCD VCNFMSHEKC LKHVRIPCTS VAPSLVRVPV
120 AHCFGPRGLH KRKFCAVCRK VLEAPALHCE VCELHLHPDC VPFACSDCRQ CHQDGHQDHD
180 THHHHWREGN LPSGARCEVC RKTCGSSDVL AGVRCEWCGV QAHSLCSAAL APECGFGRLR
240 SLVLPPACVR LLPGGFSKTQ SFRIVEAAEP GEGGDGADGS AAVGPGRETQ ATPESGKQTL
300 KIFDGDDAVR RSQFRLVTVS RLAGAEEVLE AALRAHHIPE DPGHLELCRL PPSSQACDAW
360 AGGKAGSAVI SEEGRSPGSG EATPEAWVIR ALPRAQEVLK IYPGWLKVGV AYVSVRVTPK
420 STARSVVLEV LPLLGRQAES PESFQLVEVA MGCRHVQRTM LMDEQPLLDR LQDIRQMSVR
480 QVSQTRFYVA ESRDVAPHVS LFVGGLPPGL SPEEYSSLLH EAGATKATVV SVSHIYSSQG
540 AVVLDVACFA EAERLYMLLK DMAVRGRLLT ALVLPDLLHA KLPPDSCPLL VFVNPKSGGL
600 KGRDLLCSFR KLLNPHQVFD LTNGGPLPGL HLFSQVPCFR VLVCGGDGTV GWVLGALEET
660 RYRLACPEPS VAILPLGTGN DLGRVLRWGA GYSGEDPFSV LLSVDEADAV LMDRWTILLD
720 AHEAGSAEND TADAEPPKIV QMSNYCGIGI DAELSLDFHQ AREEEPGKFT SRLHNKGVYV
780 RVGLQKISHS RSLHKQIRLQ VERQEVELPS IEGLIFINIP SWGSGADLWG SDSDTRFEKP
840 RMDDGLLEVV GVTGVVHMGQ VQGGLRSGIR IAQGSYFRVT LLKATPVQVD GEPWVQAPGH
900 MIISAAGPKV HMLRKAKQKP RRAGTTRDAR ADAAPAPESD PR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
662725
Pilz A.,Schaap D.,Hunt D.,Fitzgibbon J.
Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.
Genomics
26
599-601
1995
662726
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
662727
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
662728
Houssa B.,Schaap D.,van der Wal J.,Goto K.,Kondo H.,Yamakawa A.,Shibata M.,Takenawa T.,van Blitterswijk W.J.
Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.
J. Biol. Chem.
272
10422-10428
1997
662729
Houssa B.,de Widt J.,Kranenburg O.,Moolenaar W.H.,van Blitterswijk W.J.
Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.
J. Biol. Chem.
274
6820-6822
1999
662730
Bregoli L.,Baldassare J.J.,Raben D.M.
Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.
J. Biol. Chem.
276
23288-23295
2001
662731
Tabellini G.,Bortul R.,Santi S.,Riccio M.,Baldini G.,Cappellini A.,Billi A.M.,Berezney R.,Ruggeri A.,Cocco L.,Martelli A.M.
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.
Exp. Cell Res.
287
143-154
2003
662732
Los A.P.,van Baal J.,de Widt J.,Divecha N.,van Blitterswijk W.J.
Structure-activity relationship of diacylglycerol kinase theta.
Biochim. Biophys. Acta
1636
169-174
2004
662733
van Baal J.,de Widt J.,Divecha N.,van Blitterswijk W.J.
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
J. Biol. Chem.
280
9870-9878
2005
662734
Li D.,Urs A.N.,Allegood J.,Leon A.,Merrill A.H. Jr.,Sewer M.B.
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Mol. Cell. Biol.
27
6669-6685
2007
662735
Gellett A.M.,Kharel Y.,Sunkara M.,Morris A.J.,Lynch K.R.
Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.
Biochem. Biophys. Res. Commun.
422
758-763
2012
662736
Sato M.,Liu K.,Sasaki S.,Kunii N.,Sakai H.,Mizuno H.,Saga H.,Sakane F.
Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.
Pharmacology
92
99-107
2013
662737
Goldschmidt H.L.,Tu-Sekine B.,Volk L.,Anggono V.,Huganir R.L.,Raben D.M.
DGKtheta Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses.
Cell Rep.
14
200-207
2016