Sequence of HXK2_HUMAN
EC Number:2.7.1.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + D-glucose = ADP + D-glucose 6-phosphate
Other sequences found for EC No. 2.7.1.1
General information:
Sequence
0 MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA
60 VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR
120 GSGTQLFDHI AECLANFMDK LQIKDKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV
180 EGRDVVALIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DHNCEIGLIV GTGSNACYME
240 EMRHIDMVEG DEGRMCINME WGAFGDDGSL NDIRTEFDQE IDMGSLNPGK QLFEKMISGM
300 YMGELVRLIL VKMAKEELLF GGKLSPELLN TGRFETKDIS DIEGEKDGIR KAREVLMRLG
360 LDPTQEDCVA THRICQIVST RSASLCAATL AAVLQRIKEN KGEERLRSTI GVDGSVYKKH
420 PHFAKRLHKT VRRLVPGCDV RFLRSEDGSG KGAAMVTAVA YRLADQHRAR QKTLEHLQLS
480 HDQLLEVKRR MKVEMERGLS KETHASAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV
540 LLVRVRNGKW GGVEMHNKIY AIPQEVMHGT GDELFDHIVQ CIADFLEYMG MKGVSLPLGF
600 TFSFPCQQNS LDESILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD VVAVVNDTVG
660 TMMTCGFEDP HCEVGLIVGT GSNACYMEEM RNVELVEGEE GRMCVNMEWG AFGDNGCLDD
720 FRTEFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG
780 IFETKFLSQI ESDCLALLQV RAILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA
840 VVDRIRENRG LDALKVTVGV DGTLYKLHPH FAKVMHETVK DLAPKCDVSF LQSEDGSGKG
900 AALITAVACR IREAGQR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
45787
Deeb S.S.,Malkki M.,Laakso M.
Human hexokinase II: sequence and homology to other hexokinases.
Biochem. Biophys. Res. Commun.
197
68-74
1993
45788
Lehto M.,Huang X.,Davis E.M.,Le Beau M.M.,Laurila E.,Eriksson K.F.,Bell G.I.,Groop L.C.
Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
Diabetologia
38
1466-1474
1995
45792
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
45793
Shinohara Y.,Yamamoto K.,Kogure K.,Ichihara J.,Terada H.
Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines.
Cancer Lett.
82
27-32
1994
45794
Chiara F.,Castellaro D.,Marin O.,Petronilli V.,Brusilow W.S.,Juhaszova M.,Sollott S.J.,Forte M.,Bernardi P.,Rasola A.
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels.
PLoS ONE
3
0-0
2008
45795
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
45796
Cheung E.C.,Ludwig R.L.,Vousden K.H.
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.
Proc. Natl. Acad. Sci. U.S.A.
109
20491-20496
2012
45797
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
45798
Lin H.,Zeng J.,Xie R.,Schulz M.J.,Tedesco R.,Qu J.,Erhard K.F.,Mack J.F.,Raha K.,Rendina A.R.,Szewczuk L.M.,Kratz P.M.,Jurewicz A.J.,Cecconie T.,Martens S.,McDevitt P.J.,Martin J.D.,Chen S.B.,Jiang Y.,Nickels L.,Schwartz B.J.,Smallwood A.,Zhao B.,Campobasso N.,Qian Y.,Briand J.,Rominger C.M.,Oleykowski C.,Hardwicke M.A.,Luengo J.I.
Discovery of a novel 2,6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors.
ACS Med. Chem. Lett.
7
217-222
2016
45799
Nawaz M.H.,Ferreira J.C.,Nedyalkova L.,Zhu H.,Carrasco-Lopez C.,Kirmizialtin S.,Rabeh W.M.
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
Biosci. Rep.
38
0-0
2018
45800
Laakso M.,Malkki M.,Deeb S.S.
Amino acid substitutions in hexokinase II among patients with NIDDM.
Diabetes
44
330-334
1995
45801
Vidal-Puig A.,Printz R.L.,Stratton I.M.,Granner D.K.,Moller D.E.
Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.
Diabetes
44
340-346
1995
45802
Echwald S.M.,Bjoerbaek C.,Hansen T.,Clausen J.O.,Vestergaard H.,Zierath J.R.,Printz R.L.,Granner D.K.,Pedersen O.
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Diabetes
44
347-353
1995
