Sequence of DGKE_HUMAN
EC Number:2.7.1.107
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
Other sequences found for EC No. 2.7.1.107
General information:
Sequence
0 MEAERRPAPG SPSEGLFADG HLILWTLCSV LLPVFITFWC SLQRSRRQLH RRDIFRKSKH
60 GWRDTDLFSQ PTYCCVCAQH ILQGAFCDCC GLRVDEGCLR KADKRFQCKE IMLKNDTKVL
120 DAMPHHWIRG NVPLCSYCMV CKQQCGCQPK LCDYRCIWCQ KTVHDECMKN SLKNEKCDFG
180 EFKNLIIPPS YLTSINQMRK DKKTDYEVLA SKLGKQWTPL IILANSRSGT NMGEGLLGEF
240 RILLNPVQVF DVTKTPPIKA LQLCTLLPYY SARVLVCGGD GTVGWVLDAV DDMKIKGQEK
300 YIPQVAVLPL GTGNDLSNTL GWGTGYAGEI PVAQVLRNVM EADGIKLDRW KVQVTNKGYY
360 NLRKPKEFTM NNYFSVGPDA LMALNFHAHR EKAPSLFSSR ILNKAVYLFY GTKDCLVQEC
420 KDLNKKVELE LDGERVALPS LEGIIVLNIG YWGGGCRLWE GMGDETYPLA RHDDGLLEVV
480 GVYGSFHCAQ IQVKLANPFR IGQAHTVRLI LKCSMMPMQV DGEPWAQGPC TVTITHKTHA
540 MMLYFSGEQT DDDISSTSDQ EDIKATE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
25186
Tang W.,Bunting M.,Zimmerman G.A.,McIntyre T.M.,Prescott S.M.
Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates.
J. Biol. Chem.
271
10237-10241
1996
25187
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
25188
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
25189
Tang W.,Bardien S.,Bhattacharya S.S.,Prescott S.M.
Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa.
Gene
239
185-192
1999
25190
Epand R.M.,Kam A.,Bridgelal N.,Saiga A.,Topham M.K.
The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.
Biochemistry
43
14778-14783
2004
25191
Epand R.M.,Shulga Y.V.,Timmons H.C.,Perri A.L.,Belani J.D.,Perinpanathan K.,Johnson-McIntire L.B.,Bajjalieh S.,Dicu A.O.,Elias C.,Rychnovsky S.D.,Topham M.K.
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.
Biochemistry
46
14225-14231
2007
25192
Lung M.,Shulga Y.V.,Ivanova P.T.,Myers D.S.,Milne S.B.,Brown H.A.,Topham M.K.,Epand R.M.
Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.
J. Biol. Chem.
284
31062-31073
2009
25193
Shulga Y.V.,Topham M.K.,Epand R.M.
Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.
FEBS Lett.
585
4025-4028
2011
25194
Shulga Y.V.,Topham M.K.,Epand R.M.
Study of arachidonoyl specificity in two enzymes of the PI cycle.
J. Mol. Biol.
409
101-112
2011
25195
Sato M.,Liu K.,Sasaki S.,Kunii N.,Sakai H.,Mizuno H.,Saga H.,Sakane F.
Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.
Pharmacology
92
99-107
2013
25196
Ozaltin F.,Li B.,Rauhauser A.,An S.W.,Soylemezoglu O.,Gonul I.I.,Taskiran E.Z.,Ibsirlioglu T.,Korkmaz E.,Bilginer Y.,Duzova A.,Ozen S.,Topaloglu R.,Besbas N.,Ashraf S.,Du Y.,Liang C.,Chen P.,Lu D.,Vadnagara K.,Arbuckle S.,Lewis D.,Wakeland B.,Quigg R.J.,Ransom R.F.,Wakeland E.K.,Topham M.K.,Bazan N.G.,Mohan C.,Hildebrandt F.,Bakkaloglu A.,Huang C.L.,Attanasio M.
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN.
J. Am. Soc. Nephrol.
24
377-384
2013
25197
Lemaire M.,Fremeaux-Bacchi V.,Schaefer F.,Choi M.,Tang W.H.,Le Quintrec M.,Fakhouri F.,Taque S.,Nobili F.,Martinez F.,Ji W.,Overton J.D.,Mane S.M.,Nuernberg G.,Altmueller J.,Thiele H.,Morin D.,Deschenes G.,Baudouin V.,Llanas B.,Collard L.,Majid M.A.,Simkova E.,Nuernberg P.,Rioux-Leclerc N.,Moeckel G.W.,Gubler M.C.,Hwa J.,Loirat C.,Lifton R.P.
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome.
Nat. Genet.
45
531-536
2013
25198
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006
