Sequence of AL3A2_HUMAN
EC Number:1.2.1.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+
Other sequences found for EC No. 1.2.1.3
EC Number:1.2.1.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+
Other sequences found for EC No. 1.2.1.48
EC Number:1.2.1.94
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+
Other sequences found for EC No. 1.2.1.94
General information:
Sequence
0 MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE
60 VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ
120 PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH
180 IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT
240 CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI
300 AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA
360 LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS
420 HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV
480 KAEYY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
388215
de Laurenzi V.,Rogers G.R.,Hamrock D.J.,Marekov L.N.,Steinert P.M.,Compton J.G.,Markova N.,Rizzo W.B.
Sjogren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene.
Nat. Genet.
12
52-57
1996
388216
Rogers G.R.,Markova N.G.,De Laurenzi V.,Rizzo W.B.,Compton J.G.
Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH).
Genomics
39
127-135
1997
388217
Chang C.,Yoshida A.
Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression.
Genomics
40
80-85
1997
388218
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
388221
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
388222
Kelson T.L.,Secor McVoy J.R.,Rizzo W.B.
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization.
Biochim. Biophys. Acta
1335
99-110
1997
388223
Verhoeven N.M.,Jakobs C.,Carney G.,Somers M.P.,Wanders R.J.,Rizzo W.B.
Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid.
FEBS Lett.
429
225-228
1998
388224
Lloyd M.D.,Boardman K.D.,Smith A.,van den Brink D.M.,Wanders R.J.,Threadgill M.D.
Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjoegren-Larsson syndrome.
J. Enzym. Inhib. Med. Chem.
22
584-590
2007
388225
Sanders R.J.,Ofman R.,Dacremont G.,Wanders R.J.,Kemp S.
Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
FASEB J.
22
2064-2071
2008
388226
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
388227
Nakahara K.,Ohkuni A.,Kitamura T.,Abe K.,Naganuma T.,Ohno Y.,Zoeller R.A.,Kihara A.
The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
Mol. Cell
46
461-471
2012
388228
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
388229
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
388230
Keller M.A.,Zander U.,Fuchs J.E.,Kreutz C.,Watschinger K.,Mueller T.,Golderer G.,Liedl K.R.,Ralser M.,Krautler B.,Werner E.R.,Marquez J.A.
A gatekeeper helix determines the substrate specificity of Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.
Nat. Commun.
5
4439-4439
2014
388231
Sillen A.,Jagell S.,Wadelius C.
A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden.
Hum. Genet.
100
201-203
1997
388232
Sillen A.,Anton-Lamprecht I.,Braun-Quentin C.,Kraus C.S.,Sayli B.S.,Ayuso C.,Jagell S.,Kuester W.,Wadelius C.
Spectrum of mutations and sequence variants in the FALDH gene in patients with Sjoegren-Larsson syndrome.
Hum. Mutat.
12
377-384
1998
388233
Rizzo W.B.,Carney G.,Lin Z.
The molecular basis of Sjoegren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene.
Am. J. Hum. Genet.
65
1547-1560
1999
388234
Aoki N.,Suzuki H.,Ito K.,Ito M.
A novel point mutation of the FALDH gene in a Japanese family with Sjoegren-Larsson syndrome.
J. Invest. Dermatol.
114
1065-1066
2000
