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Sequence of IDH3A_HUMAN

EC Number:1.1.1.41

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
isocitrate dehydrogenase (NAD+)
P50213
Homo sapiens
366
39592
Reaction
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+
Other sequences found for EC No. 1.1.1.41

General information:

Sequence
show sequence in fasta format
  0 MAGPAWISKV SRLLGAFHNP KQVTRGFTGG VQTVTLIPGD GIGPEISAAV MKIFDAAKAP
 60 IQWEERNVTA IQGPGGKWMI PSEAKESMDK NKMGLKGPLK TPIAAGHPSM NLLLRKTFDL
120 YANVRPCVSI EGYKTPYTDV NIVTIRENTE GEYSGIEHVI VDGVVQSIKL ITEGASKRIA
180 EFAFEYARNN HRSNVTAVHK ANIMRMSDGL FLQKCREVAE SCKDIKFNEM YLDTVCLNMV
240 QDPSQFDVLV MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD
300 MANPTALLLS AVMMLRHMGL FDHAARIEAA CFATIKDGKS LTKDLGGNAK CSDFTEEICR
360 RVKDLD
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
305482
Kim Y.O.,Oh I.U.,Park H.S.,Jeng J.,Song B.J.,Huh T.L.
Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species.
Biochem. J.
308
63-68
1995
305483
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
305485
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
305487
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
305488
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
305489
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
305490
Ma T.,Peng Y.,Huang W.,Liu Y.,Ding J.
The beta and gamma subunits play distinct functional roles in the alpha2betagamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.
Sci. Rep.
7
41882-41882
2017
305491
Ma T.,Peng Y.,Huang W.,Ding J.
Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Sci. Rep.
7
40921-40921
2017
305492
Pierrache L.H.M.,Kimchi A.,Ratnapriya R.,Roberts L.,Astuti G.D.N.,Obolensky A.,Beryozkin A.,Tjon-Fo-Sang M.J.H.,Schuil J.,Klaver C.C.W.,Bongers E.M.H.F.,Haer-Wigman L.,Schalij N.,Breuning M.H.,Fischer G.M.,Banin E.,Ramesar R.S.,Swaroop A.,van den Born L.I.,Sharon D.,Cremers F.P.M.
Whole-exome sequencing identifies biallelic IDH3A variants as a cause of retinitis pigmentosa accompanied by pseudocoloboma.
Ophthalmology
124
992-1003
2017
305493
Sun W.,Zhang Q.
A novel variant in IDH3A identified in a case with Leber congenital amaurosis accompanied by macular pseudocoloboma.
Ophthalmic Genet.
39
662-663
2018
305494
Peter V.G.,Nikopoulos K.,Quinodoz M.,Granse L.,Farinelli P.,Superti-Furga A.,Andreasson S.,Rivolta C.
A novel missense variant in IDH3A causes autosomal recessive retinitis pigmentosa.
Ophthalmic Genet.
40
177-181
2019