Sequence of DHI1_MOUSE
EC Number:1.1.1.146
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
Other sequences found for EC No. 1.1.1.146
EC Number:1.1.1.201
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
Other sequences found for EC No. 1.1.1.201
General information:
Sequence
0 MAVMKNYLLP ILVLFLAYYY YSTNEEFRPE MLQGKKVIVT GASKGIGREM AYHLSKMGAH
60 VVLTARSEEG LQKVVSRCLE LGAASAHYIA GTMEDMTFAE QFIVKAGKLM GGLDMLILNH
120 ITQTSLSLFH DDIHSVRRVM EVNFLSYVVM STAALPMLKQ SNGSIAVISS LAGKMTQPMI
180 APYSASKFAL DGFFSTIRTE LYITKVNVSI TLCVLGLIDT ETAMKEISGI INAQASPKEE
240 CALEIIKGTA LRKSEVYYDK SPLTPILLGN PGRKIMEFFS LRYYNKDMFV SN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1049929
Rajan V.,Chapman K.E.,Lyons V.,Jamieson P.,Mullins J.J.,Edwards C.R.,Seckl J.R.
Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA.
J. Steroid Biochem. Mol. Biol.
52
141-147
1995
1049930
Oppermann U.C.T.,Netter K.J.,Maser E.
Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase.
Eur. J. Biochem.
227
202-208
1995
1049931
Voice M.W.,Seckl J.R.,Chapman K.E.
The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites.
Gene
181
233-235
1996
1049932
Kotelevtsev Y.,Holmes M.C.,Burchell A.,Houston P.M.,Schmoll D.,Jamieson P.,Best R.,Brown R.,Edwards C.R.,Seckl J.R.,Mullins J.J.
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
Proc. Natl. Acad. Sci. U.S.A.
94
14924-14929
1997
1049933
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
1049934
Mitic T.,Shave S.,Semjonous N.,McNae I.,Cobice D.F.,Lavery G.G.,Webster S.P.,Hadoke P.W.,Walker B.R.,Andrew R.
11beta-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo.
Biochem. Pharmacol.
86
146-153
2013
1049935
Beck K.R.,Kanagaratnam S.,Kratschmar D.V.,Birk J.,Yamaguchi H.,Sailer A.W.,Seuwen K.,Odermatt A.
Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2.
J. Steroid Biochem. Mol. Biol.
190
19-28
2019
1049936
Zhang J.,Osslund T.D.,Plant M.H.,Clogston C.L.,Nybo R.E.,Xiong F.,Delaney J.M.,Jordan S.R.
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes.
Biochemistry
44
6948-6957
2005
