Sequence of CBR1_MOUSE
EC Number:1.1.1.71
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
Other sequences found for EC No. 1.1.1.71
EC Number:1.1.1.184
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+
Other sequences found for EC No. 1.1.1.184
EC Number:1.1.1.189
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
Other sequences found for EC No. 1.1.1.189
EC Number:1.1.1.196
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+
Other sequences found for EC No. 1.1.1.196
EC Number:1.1.1.197
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+
Other sequences found for EC No. 1.1.1.197
General information:
Sequence
0 MSSSRPVALV TGANKGIGFA ITRDLCRKFS GDVVLAARDE ERGQTAVQKL QAEGLSPRFH
60 QLDIDNPQSI RALRDFLLKE YGGLDVLVNN AGIAFKVNDD TPFHIQAEVT MKTNFFGTRD
120 VCKELLPLIK PQGRVVNVSS MVSLRALKNC RLELQQKFRS ETITEEELVG LMNKFVEDTK
180 KGVHAEEGWP NSAYGVTKIG VTVLSRILAR KLNEQRRGDK ILLNACCPGW VRTDMAGPKA
240 TKSPEEGAET PVYLALLPPD AEGPHGQFVQ DKKVEPW
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in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
273553
Wei J.,Dlouhy S.R.,Hara A.,Ghetti B.,Hodes M.E.
Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: murine genes that express cbr map to chromosomes 16 and 11.
Genomics
34
147-148
1996
273554
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
273556
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
273557
Morgan R.A.,Beck K.R.,Nixon M.,Homer N.Z.M.,Crawford A.A.,Melchers D.,Houtman R.,Meijer O.C.,Stomby A.,Anderson A.J.,Upreti R.,Stimson R.H.,Olsson T.,Michoel T.,Cohain A.,Ruusalepp A.,Schadt E.E.,Bjoerkegren J.L.M.,Andrew R.,Kenyon C.J.,Hadoke P.W.F.,Odermatt A.,Keen J.A.,Walker B.R.
Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Sci. Rep.
7
10633-10633
2017
273558
Bell R.M.B.,Villalobos E.,Nixon M.,Miguelez-Crespo A.,Murphy L.,Fawkes A.,Coutts A.,Sharp M.G.F.,Koerner M.V.,Allan E.,Meijer O.C.,Houtman R.,Odermatt A.,Beck K.R.,Denham S.G.,Lee P.,Homer N.Z.M.,Walker B.R.,Morgan R.A.
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
Mol. Metab.
48
101225-101225
2021
