Sequence of PK3CG_HUMAN
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
EC Number:2.7.1.154
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Other sequences found for EC No. 2.7.1.154
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MELENYKQPV VLREDNCRRR RRMKPRSAAA SLSSMELIPI EFVLPTSQRK CKSPETALLH
60 VAGHGNVEQM KAQVWLRALE TSVAADFYHR LGPHHFLLLY QKKGQWYEIY DKYQVVQTLD
120 CLRYWKATHR SPGQIHLVQR HPPSEESQAF QRQLTALIGY DVTDVSNVHD DELEFTRRGL
180 VTPRMAEVAS RDPKLYAMHP WVTSKPLPEY LWKKIANNCI FIVIHRSTTS QTIKVSPDDT
240 PGAILQSFFT KMAKKKSLMD IPESQSEQDF VLRVCGRDEY LVGETPIKNF QWVRHCLKNG
300 EEIHVVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK
360 FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFTEEVLW NVWLEFSIKI
420 KDLPKGALLN LQIYCGKAPA LSSKASAESP SSESKGKVQL LYYVNLLLID HRFLLRRGEY
480 VLHMWQISGK GEDQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHQPTPDPEG
540 DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ
600 QEIVAKTYQL LARREVWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL
660 LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY
720 LRGCGTAMLH DFTQQVQVIE MLQKVTLDIK SLSAEKYDVS SQVISQLKQK LENLQNSQLP
780 ESFRVPYDPG LKAGALAIEK CKVMASKKKP LWLEFKCADP TALSNETIGI IFKHGDDLRQ
840 DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAK IQQSTVGNTG
900 AFKDEVLNHW LKEKSPTEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMITETGNL
960 FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGTSGK KTSPHFQKFQ DICVKAYLAL
1020 RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKN EEDAKKYFLD QIEVCRDKGW
1080 TVQFNWFLHL VLGIKQGEKH SA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205854
Stoyanov B.,Volinia S.,Hanck T.,Rubio I.,Loubtchenkov M.,Malek D.,Stoyanova S.,Vanhaesebroeck B.,Dhand R.,Nuernberg B.,Gierschik P.,Seedorf K.,Hsuan J.J.,Waterfield M.D.,Wetzker R.
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
Science
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1995
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Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
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Nature
424
157-164
2003
205858
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Human chromosome 7: DNA sequence and biology.
Science
300
767-772
2003
205860
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
205861
Suer S.,Sickmann A.,Meyer H.E.,Herberg F.W.,Heilmeyer L.M.G. Jr.
Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.
Eur. J. Biochem.
268
2099-2106
2001
205862
Gu C.,Park S.
The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.
Mol. Cell. Biol.
21
4579-4597
2001
205863
Naga Prasad S.V.,Laporte S.A.,Chamberlain D.,Caron M.G.,Barak L.,Rockman H.A.
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
J. Cell Biol.
158
563-575
2002
205864
Czupalla C.,Culo M.,Muller E.C.,Brock C.,Reusch H.P.,Spicher K.,Krause E.,Nurnberg B.
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
J. Biol. Chem.
278
11536-11545
2003
205865
Patrucco E.,Notte A.,Barberis L.,Selvetella G.,Maffei A.,Brancaccio M.,Marengo S.,Russo G.,Azzolino O.,Rybalkin S.D.,Silengo L.,Altruda F.,Wetzker R.,Wymann M.P.,Lembo G.,Hirsch E.
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
Cell
118
375-387
2004
205866
Meier T.I.,Cook J.A.,Thomas J.E.,Radding J.A.,Horn C.,Lingaraj T.,Smith M.C.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.
Protein Expr. Purif.
35
218-224
2004
205867
Suire S.,Coadwell J.,Ferguson G.J.,Davidson K.,Hawkins P.,Stephens L.
p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.
Curr. Biol.
15
566-570
2005
205868
Naga Prasad S.V.,Jayatilleke A.,Madamanchi A.,Rockman H.A.
Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
Nat. Cell Biol.
7
785-796
2005
205869
Resnick A.C.,Snowman A.M.,Kang B.N.,Hurt K.J.,Snyder S.H.,Saiardi A.
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
Proc. Natl. Acad. Sci. U.S.A.
102
12783-12788
2005
205870
Rommel C.,Camps M.,Ji H.
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Nat. Rev. Immunol.
7
191-201
2007
205871
Barberis L.,Hirsch E.
Targeting phosphoinositide 3-kinase gamma to fight inflammation and more.
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99
279-285
2008
205872
Oudit G.Y.,Penninger J.M.
Cardiac regulation by phosphoinositide 3-kinases and PTEN.
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82
250-260
2009
205873
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
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17-17
2011
205874
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A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
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286
16285-16296
2011
205875
Walker E.H.,Perisic O.,Ried C.,Stephens L.,Williams R.L.
Structural insights into phosphoinositide 3-kinase catalysis and signalling.
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402
313-320
1999
205876
Camps M.,Rueckle T.,Ji H.,Ardissone V.,Rintelen F.,Shaw J.,Ferrandi C.,Chabert C.,Gillieron C.,Francon B.,Martin T.,Gretener D.,Perrin D.,Leroy D.,Vitte P.-A.,Hirsch E.,Wymann M.P.,Cirillo R.,Schwarz M.K.,Rommel C.
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
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11
936-943
2005
