Sequence of DXR_ECOLI
EC Number:1.1.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 1.1.1
EC Number:1.1.1.267
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
1-deoxy-D-xylulose-5-phosphate reductoisomerase
P45568
Escherichia coli (strain K12)
398
43388
Reaction
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
Other sequences found for EC No. 1.1.1.267
General information:
Sequence
0 MKQLTILGST GSIGCSTLDV VRHNPEHFRV VALVAGKNVT RMVEQCLEFS PRYAVMDDEA
60 SAKLLKTMLQ QQGSRTEVLS GQQAACDMAA LEDVDQVMAA IVGAAGLLPT LAAIRAGKTI
120 LLANKESLVT CGRLFMDAVK QSKAQLLPVD SEHNAIFQSL PQPIQHNLGY ADLEQNGVVS
180 ILLTGSGGPF RETPLRDLAT MTPDQACRHP NWSMGRKISV DSATMMNKGL EYIEARWLFN
240 ASASQMEVLI HPQSVIHSMV RYQDGSVLAQ LGEPDMRTPI AHTMAWPNRV NSGVKPLDFC
300 KLSALTFAAP DYDRYPCLKL AMEAFEQGQA ATTALNAANE ITVAAFLAQQ IRFTDIAALN
360 LSVLEKMDMR EPQCVDDVLS VDANAREVAR KEVMRLAS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
921652
Takahashi S.,Kuzuyama T.,Watanabe H.,Seto H.
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.
Proc. Natl. Acad. Sci. U.S.A.
95
9879-9884
1998
921655
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
921656
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
921657
Fujita N.,Mori H.,Yura T.,Ishihama A.
Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.
Nucleic Acids Res.
22
1637-1639
1994
921658
Yamanaka K.,Ogura T.,Niki H.,Hiraga S.
Identification and characterization of the smbA gene, a suppressor of the mukB null mutant of Escherichia coli.
J. Bacteriol.
174
7517-7526
1992
921659
Borodovsky M.,McIninch J.,Koonin E.V.,Rudd K.E.,Medigue C.,Danchin A.
Detection of new genes in a bacterial genome using Markov models for three gene classes.
Nucleic Acids Res.
23
3554-3562
1995
921660
Radykewicz T.,Rohdich F.,Wungsintaweekul J.,Herz S.,Kis K.,Eisenreich W.,Bacher A.,Zenk M.H.,Arigoni D.
Biosynthesis of terpenoids: 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase.
FEBS Lett.
465
157-160
2000
921661
Kuzuyama T.,Takahashi S.,Takagi M.,Seto H.
Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues.
J. Biol. Chem.
275
19928-19932
2000
921662
Yajima S.,Nonaka T.,Kuzuyama T.,Seto H.,Ohsawa K.
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding.
J. Biochem.
131
313-317
2002
921663
Reuter K.,Sanderbrand S.,Jomaa H.,Wiesner J.,Steinbrecher I.,Beck E.,Hintz M.,Klebe G.,Stubbs M.T.
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.
J. Biol. Chem.
277
5378-5384
2002
921664
Steinbacher S.,Kaiser J.,Eisenreich W.,Huber R.,Bacher A.,Rohdich F.
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.
J. Biol. Chem.
278
18401-18407
2003
921665
Yajima S.,Hara K.,Sanders J.M.,Yin F.,Ohsawa K.,Wiesner J.,Jomaa H.,Oldfield E.
Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
J. Am. Chem. Soc.
126
10824-10825
2004
921666
Mac Sweeney A.,Lange R.,Fernandes R.P.,Schulz H.,Dale G.E.,Douangamath A.,Proteau P.J.,Oefner C.
The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
J. Mol. Biol.
345
115-127
2005
