Sequence of PK3CA_HUMAN
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLITIKHELF KEARKYPLHQ
60 LLQDESSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK VIEPVGNREE KILNREIGFA
120 IGMPVCEFDM VKDPEVQDFR RNILNVCKEA VDLRDLNSPH SRAMYVYPPN VESSPELPKH
180 IYNKLDKGQI IVVIWVIVSP NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK
240 LCVLEYQGKY ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPMD
300 CFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD IDKIYVRTGI
360 YHGGEPLCDN VNTQRVPCSN PRWNEWLNYD IYIPDLPRAA RLCLSICSVK GRKGAKEEHC
420 PLAWGNINLF DYTDTLVSGK MALNLWPVPH GLEDLLNPIG VTGSNPNKET PCLELEFDWF
480 SSVVKFPDMS VIEEHANWSV SREAGFSYSH AGLSNRLARD NELRENDKEQ LKAISTRDPL
540 SEITEQEKDF LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME
600 LLDCNYPDPM VRGFAVRCLE KYLTDDKLSQ YLIQLVQVLK YEQYLDNLLV RFLLKKALTN
660 QRIGHFFFWH LKSEMHNKTV SQRFGLLLES YCRACGMYLK HLNRQVEAME KLINLTDILK
720 QEKKDETQKV QMKFLVEQMR RPDFMDALQG FLSPLNPAHQ LGNLRLEECR IMSSAKRPLW
780 LNWENPDIMS ELLFQNNEII FKNGDDLRQD MLTLQIIRIM ENIWQNQGLD LRMLPYGCLS
840 IGDCVGLIEV VRNSHTIMQI QCKGGLKGAL QFNSHTLHQW LKDKNKGEIY DAAIDLFTRS
900 CAGYCVATFI LGIGDRHNSN IMVKDDGQLF HIDFGHFLDH KKKKFGYKRE RVPFVLTQDF
960 LIVISKGAQE CTKTREFERF QEMCYKAYLA IRQHANLFIN LFSMMLGSGM PELQSFDDIA
1020 YIRKTLALDK TEQEALEYFM KQMNDAHHGG WTTKMDWIFH TIKQHALN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205746
Volinia S.,Hiles I.,Ormondroyd E.,Nizetic D.,Antonacci R.,Rocchi M.,Waterfield M.
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
Genomics
24
472-477
1994
205747
Stirdivant S.M.,Ahern J.,Conroy R.R.,Barnett S.F.,Ledder L.M.,Oliff A.,Heimbrook D.C.
Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase.
Bioorg. Med. Chem.
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1997
205748
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
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2004
205749
Mitsuuchi Y.,Johnson S.W.,Sonoda G.,Tanno S.,Golemis E.A.,Testa J.R.
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
Oncogene
18
4891-4898
1999
205750
Meier T.I.,Cook J.A.,Thomas J.E.,Radding J.A.,Horn C.,Lingaraj T.,Smith M.C.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.
Protein Expr. Purif.
35
218-224
2004
205751
Buchanan C.M.,Dickson J.M.,Lee W.J.,Guthridge M.A.,Kendall J.D.,Shepherd P.R.
Oncogenic mutations of p110alpha isoform of PI 3-kinase upregulate its protein kinase activity.
PLoS ONE
8
0-0
2013
205752
Maheshwari S.,Miller M.S.,O'Meally R.,Cole R.N.,Amzel L.M.,Gabelli S.B.
Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase alpha that are critical for catalysis and substrate recognition.
J. Biol. Chem.
292
13541-13550
2017
205753
Yamaguchi H.,Yoshida S.,Muroi E.,Yoshida N.,Kawamura M.,Kouchi Z.,Nakamura Y.,Sakai R.,Fukami K.
Phosphoinositide 3-kinase signaling pathway mediated by p110{alpha} regulates invadopodia formation.
J. Cell Biol.
193
1275-1288
2011
205754
Rios J.J.,Paria N.,Burns D.K.,Israel B.A.,Cornelia R.,Wise C.A.,Ezaki M.
Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly.
Hum. Mol. Genet.
22
444-451
2013
205755
Cipriano R.,Miskimen K.L.,Bryson B.L.,Foy C.R.,Bartel C.A.,Jackson M.W.
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
Oncotarget
4
729-738
2013
205756
Huang C.-H.,Mandelker D.,Gabelli S.B.,Amzel L.M.
Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.
Cell Cycle
7
1151-1156
2008
205757
Zhao L.,Vogt P.K.
Class I PI3K in oncogenic cellular transformation.
Oncogene
27
5486-5496
2008
205758
Jia S.,Roberts T.M.,Zhao J.J.
Should individual PI3 kinase isoforms be targeted in cancer?
Curr. Opin. Cell Biol.
21
199-208
2009
205759
Rodriguez-Laguna L.,Ibanez K.,Gordo G.,Garcia-Minaur S.,Santos-Simarro F.,Agra N.,Vallespin E.,Fernandez-Montano V.E.,Martin-Arenas R.,Del Pozo A.,Gonzalez-Pecellin H.,Mena R.,Rueda-Arenas I.,Gomez M.V.,Villaverde C.,Bustamante A.,Ayuso C.,Ruiz-Perez V.L.,Nevado J.,Lapunzina P.,Lopez-Gutierrez J.C.,Martinez-Glez V.
CLAPO syndrome: identification of somatic activating PIK3CA mutations and delineation of the natural history and phenotype.
Genet. Med.
20
882-889
2018
205760
Peyre M.,Miyagishima D.,Bielle F.,Chapon F.,Sierant M.,Venot Q.,Lerond J.,Marijon P.,Abi-Jaoude S.,Le Van T.,Labreche K.,Houlston R.,Faisant M.,Clemenceau S.,Boch A.L.,Nouet A.,Carpentier A.,Boetto J.,Louvi A.,Kalamarides M.
Somatic PIK3CA mutations in sporadic cerebral cavernous malformations.
N. Engl. J. Med.
385
996-996
2021
205761
Huang C.-H.,Mandelker D.,Schmidt-Kittler O.,Samuels Y.,Velculescu V.E.,Kinzler K.W.,Vogelstein B.,Gabelli S.B.,Amzel L.M.
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science
318
1744-1748
2007
205763
Mandelker D.,Gabelli S.B.,Schmidt-Kittler O.,Zhu J.,Cheong I.,Huang C.H.,Kinzler K.W.,Vogelstein B.,Amzel L.M.
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.
Proc. Natl. Acad. Sci. U.S.A.
106
16996-17001
2009
205764
Broderick D.K.,Di C.,Parrett T.J.,Samuels Y.R.,Cummins J.M.,McLendon R.E.,Fults D.W.,Velculescu V.E.,Bigner D.D.,Yan H.
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
Cancer Res.
64
5048-5050
2004
205765
Campbell I.G.,Russell S.E.,Choong D.Y.H.,Montgomery K.G.,Ciavarella M.L.,Hooi C.S.F.,Cristiano B.E.,Pearson R.B.,Phillips W.A.
Mutation of the PIK3CA gene in ovarian and breast cancer.
Cancer Res.
64
7678-7681
2004
205766
Samuels Y.,Wang Z.,Bardelli A.,Silliman N.,Ptak J.,Szabo S.,Yan H.,Gazdar A.,Powell S.M.,Riggins G.J.,Willson J.K.V.,Markowitz S.,Kinzler K.W.,Vogelstein B.,Velculescu V.E.
High frequency of mutations of the PIK3CA gene in human cancers.
Science
304
554-554
2004
205767
Hartmann C.,Bartels G.,Gehlhaar C.,Holtkamp N.,von Deimling A.
PIK3CA mutations in glioblastoma multiforme.
Acta Neuropathol.
109
639-642
2005
205768
Li V.S.W.,Wong C.W.,Chan T.L.,Chan A.S.W.,Zhao W.,Chu K.-M.,So S.,Chen X.,Yuen S.T.,Leung S.Y.
Mutations of PIK3CA in gastric adenocarcinoma.
BMC Cancer
5
29-29
2005
205769
Ikenoue T.,Kanai F.,Hikiba Y.,Obata T.,Tanaka Y.,Imamura J.,Ohta M.,Jazag A.,Guleng B.,Tateishi K.,Asaoka Y.,Matsumura M.,Kawabe T.,Omata M.
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Cancer Res.
65
4562-4567
2005
205770
Oda K.,Stokoe D.,Taketani Y.,McCormick F.
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.
Cancer Res.
65
10669-10673
2005
205771
Velho S.,Oliveira C.,Ferreira A.,Ferreira A.C.,Suriano G.,Schwartz S. Jr.,Duval A.,Carneiro F.,Machado J.C.,Hamelin R.,Seruca R.
The prevalence of PIK3CA mutations in gastric and colon cancer.
Eur. J. Cancer
41
1649-1654
2005
205772
Wang Y.,Helland A.,Holm R.,Kristensen G.B.,Boerresen-Dale A.-L.
PIK3CA mutations in advanced ovarian carcinomas.
Hum. Mutat.
25
322-322
2005
205773
Lee J.W.,Soung Y.H.,Kim S.Y.,Lee H.W.,Park W.S.,Nam S.W.,Kim S.H.,Lee J.Y.,Yoo N.J.,Lee S.H.
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.
Oncogene
24
1477-1480
2005
205774
Qiu W.,Schoenleben F.,Li X.,Ho D.J.,Close L.G.,Manolidis S.,Bennett B.P.,Su G.H.
PIK3CA mutations in head and neck squamous cell carcinoma.
Clin. Cancer Res.
12
1441-1446
2006
205775
Or Y.Y.-Y.,Hui A.B.-Y.,To K.-F.,Lam C.N.-Y.,Lo K.-W.
PIK3CA mutations in nasopharyngeal carcinoma.
Int. J. Cancer
118
1065-1067
2006
205776
Buttitta F.,Felicioni L.,Barassi F.,Martella C.,Paolizzi D.,Fresu G.,Salvatore S.,Cuccurullo F.,Mezzetti A.,Campani D.,Marchetti A.
PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma.
J. Pathol.
208
350-355
2006
205777
Bader A.G.,Kang S.,Vogt P.K.
Cancer-specific mutations in PIK3CA are oncogenic in vivo.
Proc. Natl. Acad. Sci. U.S.A.
103
1475-1479
2006
205778
Hafner C.,Lopez-Knowles E.,Luis N.M.,Toll A.,Baselga E.,Fernandez-Casado A.,Hernandez S.,Ribe A.,Mentzel T.,Stoehr R.,Hofstaedter F.,Landthaler M.,Vogt T.,Pujol R.M.,Hartmann A.,Real F.X.
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.
Proc. Natl. Acad. Sci. U.S.A.
104
13450-13454
2007
205779
Kurek K.C.,Luks V.L.,Ayturk U.M.,Alomari A.I.,Fishman S.J.,Spencer S.A.,Mulliken J.B.,Bowen M.E.,Yamamoto G.L.,Kozakewich H.P.,Warman M.L.
Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome.
Am. J. Hum. Genet.
90
1108-1115
2012
205780
Riviere J.B.,Mirzaa G.M.,O'Roak B.J.,Beddaoui M.,Alcantara D.,Conway R.L.,St-Onge J.,Schwartzentruber J.A.,Gripp K.W.,Nikkel S.M.,Worthylake T.,Sullivan C.T.,Ward T.R.,Butler H.E.,Kramer N.A.,Albrecht B.,Armour C.M.,Armstrong L.,Caluseriu O.,Cytrynbaum C.,Drolet B.A.,Innes A.M.,Lauzon J.L.,Lin A.E.,Mancini G.M.,Meschino W.S.,Reggin J.D.,Saggar A.K.,Lerman-Sagie T.,Uyanik G.,Weksberg R.,Zirn B.,Beaulieu C.L.,Majewski J.,Bulman D.E.,O'Driscoll M.,Shendure J.,Graham J.M. Jr.,Boycott K.M.,Dobyns W.B.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Nat. Genet.
44
934-940
2012
205781
Orloff M.S.,He X.,Peterson C.,Chen F.,Chen J.L.,Mester J.L.,Eng C.
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
Am. J. Hum. Genet.
92
76-80
2013
205782
Donato N.D.,Rump A.,Mirzaa G.M.,Alcantara D.,Oliver A.,Schrock E.,Dobyns W.B.,O'Driscoll M.
Identification and characterisation of a novel constitutional PIK3CA mutation in a child lacking the typical segmental overgrowth of 'PIK3CA-related overgrowth spectrum' (PROS).
Hum. Mutat.
37
242-245
2016
