Sequence of SPL_BACSU
EC Number:4.1.99.14
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA) = thymidylyl-(3'->5')-thymidylate (in double-helical DNA)
Other sequences found for EC No. 4.1.99.14
General information:
Sequence
0 MQNPFVPQLV YIEPRALEYP LGQELQDKFE NMGIEIRETT SHNQVRNIPG KNHLQQYRNA
60 KSTLVIGVRK TLKFDSSKPS AEYAIPFATG CMGHCHYCYL QTTMGSKPYI RTYVNVEEIL
120 DQADKYMKER APEFTRFEAS CTSDIVGIDH LTHTLKRAIE HFGQSDLGKL RFVTKFHHVD
180 HLLDAKHNGK TRFRFSINAD YVIKNFEPGT SPLDKRIEAA VKVAKAGYPL GFIVAPIYIH
240 EGWEEGYRHL FEKLDAALPQ DVRHDITFEL IQHRFTKPAK RVIEKNYPKT KLELDEEKRR
300 YKWGRYGIGK YIYQKDEEHA LREALESYID TFFPNAKIEY FT
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
234141
Fajardo-Cavazos P.,Salazar C.,Nicholson W.L.
Molecular cloning and characterization of the Bacillus subtilis spore photoproduct lyase (spl) gene, which is involved in repair of UV radiation-induced DNA damage during spore germination.
J. Bacteriol.
175
1735-1744
1993
234142
Kunst F.,Ogasawara N.,Moszer I.,Albertini A.M.,Alloni G.,Azevedo V.,Bertero M.G.,Bessieres P.,Bolotin A.,Borchert S.,Borriss R.,Boursier L.,Brans A.,Braun M.,Brignell S.C.,Bron S.,Brouillet S.,Bruschi C.V.,Caldwell B.,Capuano V.,Carter N.M.,Choi S.-K.,Codani J.-J.,Connerton I.F.,Cummings N.J.,Daniel R.A.,Denizot F.,Devine K.M.,Duesterhoeft A.,Ehrlich S.D.,Emmerson P.T.,Entian K.-D.,Errington J.,Fabret C.,Ferrari E.,Foulger D.,Fritz C.,Fujita M.,Fujita Y.,Fuma S.,Galizzi A.,Galleron N.,Ghim S.-Y.,Glaser P.,Goffeau A.,Golightly E.J.,Grandi G.,Guiseppi G.,Guy B.J.,Haga K.,Haiech J.,Harwood C.R.,Henaut A.,Hilbert H.,Holsappel S.,Hosono S.,Hullo M.-F.,Itaya M.,Jones L.-M.,Joris B.,Karamata D.,Kasahara Y.,Klaerr-Blanchard M.,Klein C.,Kobayashi Y.,Koetter P.,Koningstein G.,Krogh S.,Kumano M.,Kurita K.,Lapidus A.,Lardinois S.,Lauber J.,Lazarevic V.,Lee S.-M.,Levine A.,Liu H.,Masuda S.,Mauel C.,Medigue C.,Medina N.,Mellado R.P.,Mizuno M.,Moestl D.,Nakai S.,Noback M.,Noone D.,O'Reilly M.,Ogawa K.,Ogiwara A.,Oudega B.,Park S.-H.,Parro V.,Pohl T.M.,Portetelle D.,Porwollik S.,Prescott A.M.,Presecan E.,Pujic P.,Purnelle B.,Rapoport G.,Rey M.,Reynolds S.,Rieger M.,Rivolta C.,Rocha E.,Roche B.,Rose M.,Sadaie Y.,Sato T.,Scanlan E.,Schleich S.,Schroeter R.,Scoffone F.,Sekiguchi J.,Sekowska A.,Seror S.J.,Serror P.,Shin B.-S.,Soldo B.,Sorokin A.,Tacconi E.,Takagi T.,Takahashi H.,Takemaru K.,Takeuchi M.,Tamakoshi A.,Tanaka T.,Terpstra P.,Tognoni A.,Tosato V.,Uchiyama S.,Vandenbol M.,Vannier F.,Vassarotti A.,Viari A.,Wambutt R.,Wedler E.,Wedler H.,Weitzenegger T.,Winters P.,Wipat A.,Yamamoto H.,Yamane K.,Yasumoto K.,Yata K.,Yoshida K.,Yoshikawa H.-F.,Zumstein E.,Yoshikawa H.,Danchin A.
The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.
Nature
390
249-256
1997
234143
Mueller J.,Schiel S.,Ordal G.W.,Saxild H.H.
Functional and genetic characterization of mcpC, which encodes a third methyl-accepting chemotaxis protein in Bacillus subtilis.
Microbiology
143
3231-3240
1997
234144
Pedraza-Reyes M.,Gutierrez-Corona F.,Nicholson W.L.
Temporal regulation and forespore-specific expression of the spore photoproduct lyase gene by sigma-G RNA polymerase during Bacillus subtilis sporulation.
J. Bacteriol.
176
3983-3991
1994
234145
Rebeil R.,Nicholson W.L.
The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase.
Proc. Natl. Acad. Sci. U.S.A.
98
9038-9043
2001
234146
Cheek J.,Broderick J.B.
Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate.
J. Am. Chem. Soc.
124
2860-2861
2002
234147
Fajardo-Cavazos P.,Rebeil R.,Nicholson W.L.
Essential cysteine residues in Bacillus subtilis spore photoproduct lyase identified by alanine scanning mutagenesis.
Curr. Microbiol.
51
331-335
2005
234148
Friedel M.G.,Berteau O.,Pieck J.C.,Atta M.,Ollagnier-de-Choudens S.,Fontecave M.,Carell T.
The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion.
Chem. Commun. (Camb.)
4
445-447
2006
234149
Buis J.M.,Cheek J.,Kalliri E.,Broderick J.B.
Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily.
J. Biol. Chem.
281
25994-26003
2006
234150
Chandor A.,Berteau O.,Douki T.,Gasparutto D.,Sanakis Y.,Ollagnier-de-Choudens S.,Atta M.,Fontecave M.
Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis.
J. Biol. Chem.
281
26922-26931
2006
234151
Chandor-Proust A.,Berteau O.,Douki T.,Gasparutto D.,Ollagnier-de-Choudens S.,Fontecave M.,Atta M.
DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitution.
J. Biol. Chem.
283
36361-36368
2008
