Sequence of GLY1_YEAST
EC Number:4.1.2.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
low-specificity L-threonine aldolase
P37303
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
387
42815
Reaction
L-allo-threonine = glycine + acetaldehyde
Other sequences found for EC No. 4.1.2.48
General information:
Sequence
0 MTEFELPPKY ITAANDLRSD TFTTPTAEMM EAALEASIGD AVYGEDVDTV RLEQTVARMA
60 GKEAGLFCVS GTLSNQIAIR THLMQPPYSI LCDYRAHVYT HEAAGLAILS QAMVVPVVPS
120 NGDYLTLEDI KSHYVPDDGD IHGAPTRLIS LENTLHGIVY PLEELVRIKA WCMENGLKLH
180 CDGARIWNAA AQSGVPLKQY GEIFDSISIC LSKSMGAPIG SVLVGNLKFV KKATHFRKQQ
240 GGGIRQSGMM ARMALVNINN DWKSQLLYSH SLAHELAEYC EAKGIPLESP ADTNFVFINL
300 KAARMDPDVL VKKGLKYNVK LMGGRVSFHY QVTRDTLEKV KLAISEAFDY AKEHPFDCNG
360 PTQIYRSEST EVDVDGNAIR EIKTYKY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
933314
McNeil J.B.,McIntosh E.M.,Taylor B.V.,Zhang F.-R.,Tang S.,Bognar A.L.
Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine.
J. Biol. Chem.
269
9155-9165
1994
933315
Dietrich F.S.,Mulligan J.T.,Hennessy K.M.,Yelton M.A.,Allen E.,Araujo R.,Aviles E.,Berno A.,Brennan T.,Carpenter J.,Chen E.,Cherry J.M.,Chung E.,Duncan M.,Guzman E.,Hartzell G.,Hunicke-Smith S.,Hyman R.W.,Kayser A.,Komp C.,Lashkari D.,Lew H.,Lin D.,Mosedale D.,Nakahara K.,Namath A.,Norgren R.,Oefner P.,Oh C.,Petel F.X.,Roberts D.,Sehl P.,Schramm S.,Shogren T.,Smith V.,Taylor P.,Wei Y.,Botstein D.,Davis R.W.
The nucleotide sequence of Saccharomyces cerevisiae chromosome V.
Nature
387
78-81
1997
933316
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
933317
Liu J.-Q.,Nagata S.,Dairi T.,Misono H.,Shimizu S.,Yamada H.
The GLY1 gene of Saccharomyces cerevisiae encodes a low-specific L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine -- expression of the gene in Escherichia coli and purification and characterization of the enzyme.
Eur. J. Biochem.
245
289-293
1997
933318
Monschau N.,Stahmann K.-P.,Sahm H.,McNeil J.B.,Bognar A.L.
Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis.
FEMS Microbiol. Lett.
150
55-60
1997
933319
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
933320
Peng J.,Schwartz D.,Elias J.E.,Thoreen C.C.,Cheng D.,Marsischky G.,Roelofs J.,Finley D.,Gygi S.P.
A proteomics approach to understanding protein ubiquitination.
Nat. Biotechnol.
21
921-926
2003
933321
Hitchcock A.L.,Auld K.,Gygi S.P.,Silver P.A.
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
Proc. Natl. Acad. Sci. U.S.A.
100
12735-12740
2003
933322
Gruhler A.,Olsen J.V.,Mohammed S.,Mortensen P.,Faergeman N.J.,Mann M.,Jensen O.N.
Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
Mol. Cell. Proteomics
4
310-327
2005
933323
Li X.,Gerber S.A.,Rudner A.D.,Beausoleil S.A.,Haas W.,Villen J.,Elias J.E.,Gygi S.P.
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
J. Proteome Res.
6
1190-1197
2007
933324
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
933325
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
933326
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
933327
Starita L.M.,Lo R.S.,Eng J.K.,von Haller P.D.,Fields S.
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Proteomics
12
236-240
2012
