Sequence of ODPA_MOUSE
EC Number:1.2.1.104
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
Other sequences found for EC No. 1.2.1.104
EC Number:1.2.4.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
Other sequences found for EC No. 1.2.4.1
General information:
Sequence
0 MRKMLAAVSR VLAGSAQKPA SRVLVASRNF ANDATFEIKK CDLHRLEEGP PVTTVLTRED
60 GLKYYRMMQT VRRMELKADQ LYKQKIIRGF CHLCDGQEAC CVGLEAGINP TDHLITAYRA
120 HGFTFTRGLP VRAILAELTG RRGGCAKGKG GSMHMYAKNF YGGNGIVGAQ VPLGAGIALA
180 CKYNGKDEVC LTLYGDGAAN QGQIFEAYNM AALWKLPCIF ICENNRYGMG TSVERAAAST
240 DYYKRGDFIP GLRVDGMDIL CVREATKFAA AYCRSGKGPI LMELQTYRYH GHSMSDPGVS
300 YRTREEIQEV RSKSDPIMLL KDRMVNSNLA SVEELKEIDV EVRKEIEDAA QFATADPEPP
360 LEELGYHIYS SDPPFEVRGA NQWIKFKSVS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
580309
Fitzgerald G.F.,Hutchison W.M.,Dahl H.-H.M.
Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes.
Biochim. Biophys. Acta
1131
83-90
1992
580310
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
580312
Johnson M.T.,Mahmood S.,Hyatt S.L.,Yang H.S.,Soloway P.D.,Hanson R.W.,Patel M.S.
Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development.
Mol. Genet. Metab.
74
293-302
2001
580313
Johnson M.T.,Freeman E.A.,Gardner D.K.,Hunt P.A.
Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo.
Biol. Reprod.
77
2-8
2007
580314
Lee J.,Xu Y.,Chen Y.,Sprung R.,Kim S.C.,Xie S.,Zhao Y.
Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
Mol. Cell. Proteomics
6
669-676
2007
580315
Villen J.,Beausoleil S.A.,Gerber S.A.,Gygi S.P.
Large-scale phosphorylation analysis of mouse liver.
Proc. Natl. Acad. Sci. U.S.A.
104
1488-1493
2007
580316
Sidhu S.,Gangasani A.,Korotchkina L.G.,Suzuki G.,Fallavollita J.A.,Canty J.M. Jr.,Patel M.S.
Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice.
Am. J. Physiol.
295
0-0
2008
580317
Ballif B.A.,Carey G.R.,Sunyaev S.R.,Gygi S.P.
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
J. Proteome Res.
7
311-318
2008
580318
Zhou H.,Ye M.,Dong J.,Han G.,Jiang X.,Wu R.,Zou H.
Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
J. Proteome Res.
7
3957-3967
2008
580319
Rardin M.J.,Wiley S.E.,Naviaux R.K.,Murphy A.N.,Dixon J.E.
Monitoring phosphorylation of the pyruvate dehydrogenase complex.
Anal. Biochem.
389
157-164
2009
580320
Trost M.,English L.,Lemieux S.,Courcelles M.,Desjardins M.,Thibault P.
The phagosomal proteome in interferon-gamma-activated macrophages.
Immunity
30
143-154
2009
580321
Srinivasan M.,Choi C.S.,Ghoshal P.,Pliss L.,Pandya J.D.,Hill D.,Cline G.,Patel M.S.
Beta-cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.
Am. J. Physiol.
299
0-0
2010
580322
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
580323
Jing E.,O'Neill B.T.,Rardin M.J.,Kleinridders A.,Ilkeyeva O.R.,Ussar S.,Bain J.R.,Lee K.Y.,Verdin E.M.,Newgard C.B.,Gibson B.W.,Kahn C.R.
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.
Diabetes
62
3404-3417
2013
580324
Park J.,Chen Y.,Tishkoff D.X.,Peng C.,Tan M.,Dai L.,Xie Z.,Zhang Y.,Zwaans B.M.,Skinner M.E.,Lombard D.B.,Zhao Y.
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Mol. Cell
50
919-930
2013
580325
Rardin M.J.,Newman J.C.,Held J.M.,Cusack M.P.,Sorensen D.J.,Li B.,Schilling B.,Mooney S.D.,Kahn C.R.,Verdin E.,Gibson B.W.
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Proc. Natl. Acad. Sci. U.S.A.
110
6601-6606
2013
