Sequence of FAB1_YEAST
EC Number:2.7.1.150
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
1-phosphatidylinositol-3-phosphate 5-kinase
P34756
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2278
257420
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Other sequences found for EC No. 2.7.1.150
General information:
Sequence
0 MSSEEPHASI SFPDGSHVRS SSTGTSSVNT IDATLSRPNY IKKPSLHIMS TSTTSTTTDL
60 VTNPILSNIS VPKISPPTSS SIATATSTSH VTGTASHSNI KANANTSTSV NKKNLPPTTS
120 GRIPSSTIKR YPSRYKPSHS LQLPIKNDSN FKRSSIYASK STVTAIPIRN NRPISMQNSY
180 ARTPDSDHDD VGDEVSSIKS ASSSLTASLS KSFLFAFYNN RKKDKTSNNG VLSKEYWMKD
240 ESSKECFSCG KTFNTFRRKH HCRICGQIFC SSCTLLIDGD RFGCHAKMRV CYNCYEHADT
300 YEDSSDEEND STMQLNEPRS RSRSRSSNTN PYSHSHSHLH LISQDNHNGT DLHDPVAATD
360 NPQQQNEVYL LNDDDVQSIM TSGEDSKLFI STPPPPPKMA IPATKQGGSL EISFDSENDR
420 ALHYQDDNPG RHHHLDSVPT RYTIRDMDNI SHYDTNSNST LRPHYNTNNS TITINNLNNT
480 TSNNSNYNNT NSNSNINNPA HSLRRSIFHY VSSNSVNKDS NNSSATPASS AQSSSILDPA
540 NRIIGNYAHR NYKFKFNYNS KGPSQQNDTA NGNNDNNNNN NNNNNNNNNN SASGIADNNN
600 IPSNDNGTTF TLDKKKRNPL TKSKSTSAYL EYPLNEEDSS EDEGSMSIYS VLNDDHKTDN
660 PIRSMRNSTK SFQRAQASLQ RMRFRRKSKS KHFPNNSKSS IYRDLNFLTN STPNLLSVVS
720 DDNLYDDSSP LQDKASSSAA SRLTDRKFSN SSGSNNNSNS NSNINTDPWK RIASISGFKL
780 KKEKKRELNE VSLLHMHALL KQLLNDQEIS NLQEWITLLD GALRKVLRTI LNARDLNTLD
840 FRQTYVKIKR ISGGSPQNSE YIDGVVFSKA LPSKTMPRHL KNPRILLIMF PLEYQKNNNH
900 FLSIESVFRQ EREYLDKLVS RLKSLHPDII YVGANVSGYA LELLNDSGIV VQFNMKPQVI
960 ERIAKLTEAD IAISVDKLAT NIKMGECETF EVKSYIYGNI SKTYTFLRGC NPELGGTILL
1020 RGDSLENLRK IKQVSEFMVY AIFSLKLESS FFNDNFIQLS TDVYLKRAES KKLQVFEGYF
1080 ADFLIKFNNR ILTVSPTVDF PIPFLLEKAR GLEKKLIERI NQYESESDLD RQTQLNMLQG
1140 LESTITKKHL GNLIKFLHEM EIENLELEFQ KRSRQWEVSY SSSQNLLGTG SHQSITVLYS
1200 MVSTKTATPC VGPQIVTIDY FWDSDISIGQ FIENVVGTAR YPCQQGCNGL YLDHYRSYVH
1260 GSGKVDVLIE KFQTRLPKLK DIILTWSYCK KCGTSTPILQ ISEKTWNHSF GKYLEVMFWS
1320 YKDSVTGIGK CPHDFTKDHV KYFGYNDLVV RLEYSDLEVH ELITPPRKIK WKPHIDIKLK
1380 VELYYKILEK INNFYGSVLS RLERIKLDSM TKDKVLSGQA KIIELKSNAT EEQKLMLQDL
1440 DTFYADSPCD QHLPLNLVIK SLYDKAVNWN STFAIFAKSY LPSETDISRI TAKQLKKLFY
1500 DSSRKDSEDK KSLHDEKAKT RKPEKNELPL EGLKDVEKPK IDSKNTTENR DRTNEPQNAV
1560 TITTFKDDTP IIPTSGTSHL TVTPSASSVS SSLTPQTEER PPISRSGTGI SMTHDKSTRP
1620 NIRKMSSDSS LCGLASLANE YSKNNKVSKL ATFFDQMHFD ALSKEFELER ERERLQLNKD
1680 KYQAIRLQTS TPIVEIYKNV KDAVDEPLHS RSSGNNLSSA NVKTLEAPVG EHSRANNCNP
1740 PNLDQNLETE LENSISQWGE NILNPSGKTT ASTHLNSKPV VKETSENPKS IVRESDNSKS
1800 EPLPPVITTT TVNKVESTPQ PEKSLLMKTL SNFWADRSAY LWKPLVYPTC PSEHIFTDSD
1860 VIIREDEPSS LIAFCLSTSD YRNKMMNLNV QQQQQQQTAE AAPAKTGGNS GGTTQTGDPS
1920 VNISPSVSTT SHNKGRDSEI SSLVTTKEGL LNTPPIEGAR DRTPQESQTH SQANLDTLQE
1980 LEKIMTKKTA THLRYQFEEG LTVMSCKIFF TEHFDVFRKI CDCQENFIQS LSRCVKWDSN
2040 GGKSGSGFLK TLDDRFIIKE LSHAELEAFI KFAPSYFEYM AQAMFHDLPT TLAKVFGFYQ
2100 IQVKSSISSS KSYKMDVIIM ENLFYEKKTT RIFDLKGSMR NRHVEQTGKA NEVLLDENMV
2160 EYIYESPIHV REYDKKLLRA SVWNDTLFLA KMNVMDYSLV IGIDNEGYTL TVGIIDFIRT
2220 FTWDKKLESW VKEKGLVGGA SVIKQPTVVT PRQYKKRFRE AMERYILMVP DPWYREGN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
32274
Yamamoto A.,Dewald D.B.,Boronenkov I.V.,Anderson R.A.,Emr S.D.,Koshland D.
Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast.
Mol. Biol. Cell
6
525-539
1995
32275
Murakami Y.,Naitou M.,Hagiwara H.,Shibata T.,Ozawa M.,Sasanuma S.,Sasanuma M.,Tsuchiya Y.,Soeda E.,Yokoyama K.,Yamazaki M.,Tashiro H.,Eki T.
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.
Nat. Genet.
10
261-268
1995
32276
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
32277
Cooke F.T.,Dove S.K.,McEwen R.K.,Painter G.,Holmes A.B.,Hall M.N.,Michell R.H.,Parker P.J.
The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae.
Curr. Biol.
8
1219-1222
1998
32278
Gary J.D.,Wurmser A.E.,Bonangelino C.J.,Weisman L.S.,Emr S.D.
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis.
J. Cell Biol.
143
65-79
1998
32279
Zheng B.,Wu J.N.,Schober W.,Lewis D.E.,Vida T.
Isolation of yeast mutants defective for localization of vacuolar vital dyes.
Proc. Natl. Acad. Sci. U.S.A.
95
11721-11726
1998
32280
Bonangelino C.J.,Nau J.J.,Duex J.E.,Brinkman M.,Wurmser A.E.,Gary J.D.,Emr S.D.,Weisman L.S.
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.
J. Cell Biol.
156
1015-1028
2002
32281
Gary J.D.,Sato T.K.,Stefan C.J.,Bonangelino C.J.,Weisman L.S.,Emr S.D.
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.
Mol. Biol. Cell
13
1238-1251
2002
32282
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
32283
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
32284
Duex J.E.,Tang F.,Weisman L.S.
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover.
J. Cell Biol.
172
693-704
2006
32285
Jin N.,Chow C.Y.,Liu L.,Zolov S.N.,Bronson R.,Davisson M.,Petersen J.L.,Zhang Y.,Park S.,Duex J.E.,Goldowitz D.,Meisler M.H.,Weisman L.S.
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
EMBO J.
27
3221-3234
2008
32286
Botelho R.J.,Efe J.A.,Teis D.,Emr S.D.
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.
Mol. Biol. Cell
19
4273-4286
2008
32287
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
32288
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
32289
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
32290
Lang M.J.,Strunk B.S.,Azad N.,Petersen J.L.,Weisman L.S.
An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels.
Mol. Biol. Cell
28
858-864
2017
32291
Miner G.E.,Sullivan K.D.,Guo A.,Jones B.C.,Hurst L.R.,Ellis E.C.,Starr M.L.,Fratti R.A.
Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion.
Mol. Biol. Cell
30
201-208
2019
