Sequence of TOR2_YEAST
EC Number:2.7.1.67
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
1-phosphatidylinositol 4-kinase
P32600
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2474
281568
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Other sequences found for EC No. 2.7.1.67
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphatidylinositol 3-kinase
P32600
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2474
281568
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
P32600
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2474
281568
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MNKYINKYTT PPNLLSLRQR AEGKHRTRKK LTHKSHSHDD EMSTTSNTDS NHNGPNDSGR
60 VITGSAGHIG KISFVDSELD TTFSTLNLIF DKLKSDVPQE RASGANELST TLTSLAREVS
120 AEQFQRFSNS LNNKIFELIH GFTSSEKIGG ILAVDTLISF YLSTEELPNQ TSRLANYLRV
180 LIPSSDIEVM RLAANTLGRL TVPGGTLTSD FVEFEVRTCI DWLTLTADNN SSSSKLEYRR
240 HAALLIIKAL ADNSPYLLYP YVNSILDNIW VPLRDAKLII RLDAAVALGK CLTIIQDRDP
300 ALGKQWFQRL FQGCTHGLSL NTNDSVHATL LVFRELLSLK APYLRDKYDD IYKSTMKYKE
360 YKFDVIRREV YAILPLLAAF DPAIFTKKYL DRIMVHYLRY LKNIDMNAAN NSDKPFILVS
420 IGDIAFEVGS SISPYMTLIL DNIREGLRTK FKVRKQFEKD LFYCIGKLAC ALGPAFAKHL
480 NKDLLNLMLN CPMSDHMQET LMILNEKIPS LESTVNSRIL NLLSISLSGE KFIQSNQYDF
540 NNQFSIEKAR KSRNQSFMKK TGESNDDITD AQILIQCFKM LQLIHHQYSL TEFVRLITIS
600 YIEHEDSSVR KLAALTSCDL FIKDDICKQT SVHALHSVSE VLSKLLMIAI TDPVAEIRLE
660 ILQHLGSNFD PQLAQPDNLR LLFMALNDEI FGIQLEAIKI IGRLSSVNPA YVVPSLRKTL
720 LELLTQLKFS NMPKKKEESA TLLCTLINSS DEVAKPYIDP ILDVILPKCQ DASSAVASTA
780 LKVLGELSVV GGKEMTRYLK ELMPLIINTF QDQSNSFKRD AALTTLGQLA ASSGYVVGPL
840 LDYPELLGIL INILKTENNP HIRRGTVRLI GILGALDPYK HREIEVTSNS KSSVEQNAPS
900 IDIALLMQGV SPSNDEYYPT VVIHNLMKIL NDPSLSIHHT AAIQAIMHIF QNLGLRCVSF
960 LDQIIPGIIL VMRSCPPSQL DFYFQQLGSL ISIVKQHIRP HVEKIYGVIR EFFPIIKLQI
1020 TIISVIESIS KALEGEFKRF VPETLTFFLD ILENDQSNKR IVPIRILKSL VTFGPNLEDY
1080 SHLIMPIVVR MTEYSAGSLK KISIITLGRL AKNINLSEMS SRIVQALVRI LNNGDRELTK
1140 ATMNTLSLLL LQLGTDFVVF VPVINKALLR NRIQHSVYDQ LVNKLLNNEC LPTNIIFDKE
1200 NEVPERKNYE DEMQVTKLPV NQNILKNAWY CSQQKTKEDW QEWIRRLSIQ LLKESPSACL
1260 RSCSSLVSVY YPLARELFNA SFSSCWVELQ TSYQEDLIQA LCKALSSSEN PPEIYQMLLN
1320 LVEFMEHDDK PLPIPIHTLG KYAQKCHAFA KALHYKEVEF LEEPKNSTIE ALISINNQLH
1380 QTDSAIGILK HAQQHNELQL KETWYEKLQR WEDALAAYNE KEAAGEDSVE VMMGKLRSLY
1440 ALGEWEELSK LASEKWGTAK PEVKKAMAPL AAGAAWGLEQ WDEIAQYTSV MKSQSPDKEF
1500 YDAILCLHRN NFKKAEVHIF NARDLLVTEL SALVNESYNR AYNVVVRAQI IAELEEIIKY
1560 KKLPQNSDKR LTMRETWNTR LLGCQKNIDV WQRILRVRSL VIKPKEDAQV RIKFANLCRK
1620 SGRMALAKKV LNTLLEETDD PDHPNTAKAS PPVVYAQLKY LWATGLQDEA LKQLINFTSR
1680 MAHDLGLDPN NMIAQSVPQQ SKRVPRHVED YTKLLARCFL KQGEWRVCLQ PKWRLSNPDS
1740 ILGSYLLATH FDNTWYKAWH NWALANFEVI SMLTSVSKKK QEGSDASSVT DINEFDNGMI
1800 GVNTFDAKEV HYSSNLIHRH VIPAIKGFFH SISLSESSSL QDALRLLTLW FTFGGIPEAT
1860 QAMHEGFNLI QIGTWLEVLP QLISRIHQPN QIVSRSLLSL LSDLGKAHPQ ALVYPLMVAI
1920 KSESLSRQKA ALSIIEKMRI HSPVLVDQAE LVSHELIRMA VLWHEQWYEG LDDASRQFFG
1980 EHNTEKMFAA LEPLYEMLKR GPETLREISF QNSFGRDLND AYEWLMNYKK SKDVSNLNQA
2040 WDIYYNVFRK IGKQLPQLQT LELQHVSPKL LSAHDLELAV PGTRASGGKP IVKISKFEPV
2100 FSVISSKQRP RKFCIKGSDG KDYKYVLKGH EDIRQDSLVM QLFGLVNTLL QNDAECFRRH
2160 LDIQQYPAIP LSPKSGLLGW VPNSDTFHVL IREHREAKKI PLNIEHWVML QMAPDYDNLT
2220 LLQKVEVFTY ALNNTEGQDL YKVLWLKSRS SETWLERRTT YTRSLAVMSM TGYILGLGDR
2280 HPSNLMLDRI TGKVIHIDFG DCFEAAILRE KFPEKVPFRL TRMLTYAMEV SGIEGSFRIT
2340 CENVMKVLRD NKGSLMAILE AFAFDPLINW GFDLPTKKIE EETGIQLPVM NANELLSNGA
2400 ITEEEVQRVE NEHKNAIRNA RAMLVLKRIT DKLTGNDIRR FNDLDVPEQV DKLIQQATSV
2460 ENLCQHYIGW CPFW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
110513
Kunz J.,Henriquez R.,Schneider U.,Deuter-Reinhard M.,Movva N.,Hall M.N.
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
Cell
73
585-596
1993
110514
Dujon B.,Alexandraki D.,Andre B.,Ansorge W.,Baladron V.,Ballesta J.P.G.,Banrevi A.,Bolle P.-A.,Bolotin-Fukuhara M.,Bossier P.,Bou G.,Boyer J.,Buitrago M.J.,Cheret G.,Colleaux L.,Daignan-Fornier B.,del Rey F.,Dion C.,Domdey H.,Duesterhoeft A.,Duesterhus S.,Entian K.-D.,Erfle H.,Esteban P.F.,Feldmann H.,Fernandes L.,Fobo G.M.,Fritz C.,Fukuhara H.,Gabel C.,Gaillon L.,Garcia-Cantalejo J.M.,Garcia-Ramirez J.J.,Gent M.E.,Ghazvini M.,Goffeau A.,Gonzalez A.,Grothues D.,Guerreiro P.,Hegemann J.H.,Hewitt N.,Hilger F.,Hollenberg C.P.,Horaitis O.,Indge K.J.,Jacquier A.,James C.M.,Jauniaux J.-C.,Jimenez A.,Keuchel H.,Kirchrath L.,Kleine K.,Koetter P.,Legrain P.,Liebl S.,Louis E.J.,Maia e Silva A.,Marck C.,Monnier A.-L.,Moestl D.,Mueller S.,Obermaier B.,Oliver S.G.,Pallier C.,Pascolo S.,Pfeiffer F.,Philippsen P.,Planta R.J.,Pohl F.M.,Pohl T.M.,Poehlmann R.,Portetelle D.,Purnelle B.,Puzos V.,Ramezani Rad M.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Richard G.-F.,Rieger M.,Rodrigues-Pousada C.,Rose M.,Rupp T.,Santos M.A.,Schwager C.,Sensen C.,Skala J.,Soares H.,Sor F.,Stegemann J.,Tettelin H.,Thierry A.,Tzermia M.,Urrestarazu L.A.,van Dyck L.,van Vliet-Reedijk J.C.,Valens M.,Vandenbol M.,Vilela C.,Vissers S.,von Wettstein D.,Voss H.,Wiemann S.,Xu G.,Zimmermann J.,Haasemann M.,Becker I.,Mewes H.-W.
Complete DNA sequence of yeast chromosome XI.
Nature
369
371-378
1994
110515
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
110516
Zheng X.-F.,Florentino D.,Chen J.,Crabtree G.R.,Schreiber S.L.
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin.
Cell
82
121-130
1995
110517
Cardenas M.E.,Heitman J.
FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
EMBO J.
14
5892-5907
1995
110518
Barbet N.C.,Schneider U.,Helliwell S.B.,Stansfield I.,Tuite M.F.,Hall M.N.
TOR controls translation initiation and early G1 progression in yeast.
Mol. Biol. Cell
7
25-42
1996
110519
Schmidt A.,Kunz J.,Hall M.N.
TOR2 is required for organization of the actin cytoskeleton in yeast.
Proc. Natl. Acad. Sci. U.S.A.
93
13780-13785
1996
110520
Schmidt A.,Beck T.,Koller A.,Kunz J.,Hall M.N.
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
EMBO J.
17
6924-6931
1998
110521
Berset C.,Trachsel H.,Altmann M.
The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.
Proc. Natl. Acad. Sci. U.S.A.
95
4264-4269
1998
110522
Jiang Y.,Broach J.R.
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.
EMBO J.
18
2782-2792
1999
110523
Powers T.,Walter P.
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.
Mol. Biol. Cell
10
987-1000
1999
110524
Beck T.,Hall M.N.
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.
Nature
402
689-692
1999
110525
Kunz J.,Schneider U.,Howald I.,Schmidt A.,Hall M.N.
HEAT repeats mediate plasma membrane localization of Tor2p in yeast.
J. Biol. Chem.
275
37011-37020
2000
110526
Jacinto E.,Guo B.,Arndt K.T.,Schmelzle T.,Hall M.N.
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Mol. Cell
8
1017-1026
2001
110527
Loewith R.,Jacinto E.,Wullschleger S.,Lorberg A.,Crespo J.L.,Bonenfant D.,Oppliger W.,Jenoe P.,Hall M.N.
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Mol. Cell
10
457-468
2002
110528
Wedaman K.P.,Reinke A.,Anderson S.,Yates J.R. III,McCaffery J.M.,Powers T.
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.
Mol. Biol. Cell
14
1204-1220
2003
110529
deHart A.K.A.,Schnell J.D.,Allen D.A.,Tsai J.-Y.,Hicke L.
Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway.
Mol. Biol. Cell
14
4676-4684
2003
110530
Martin D.E.,Soulard A.,Hall M.N.
TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1.
Cell
119
969-979
2004
110531
Audhya A.,Loewith R.,Parsons A.B.,Gao L.,Tabuchi M.,Zhou H.,Boone C.,Hall M.N.,Emr S.D.
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.
EMBO J.
23
3747-3757
2004
110532
Wullschleger S.,Loewith R.,Oppliger W.,Hall M.N.
Molecular organization of target of rapamycin complex 2.
J. Biol. Chem.
280
30697-30704
2005
110533
Fadri M.,Daquinag A.,Wang S.,Xue T.,Kunz J.
The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.
Mol. Biol. Cell
16
1883-1900
2005
110534
Kamada Y.,Fujioka Y.,Suzuki N.N.,Inagaki F.,Wullschleger S.,Loewith R.,Hall M.N.,Ohsumi Y.
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
Mol. Cell. Biol.
25
7239-7248
2005
110535
Mulet J.M.,Martin D.E.,Loewith R.,Hall M.N.
Mutual antagonism of TOR and calcineurin signaling.
J. Biol. Chem.
281
33000-33007
2006
110536
Urban J.,Soulard A.,Huber A.,Lippman S.,Mukhopadhyay D.,Deloche O.,Wanke V.,Anrather D.,Ammerer G.,Riezman H.,Broach J.R.,De Virgilio C.,Hall M.N.,Loewith R.
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Mol. Cell
26
663-674
2007
110537
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
110538
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
110539
Gonzalez A.,Shimobayashi M.,Eisenberg T.,Merle D.A.,Pendl T.,Hall M.N.,Moustafa T.
TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae.
PLoS ONE
10
0-0
2015
110540
Ukai H.,Araki Y.,Kira S.,Oikawa Y.,May A.I.,Noda T.
Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane.
PLoS Genet.
14
0-0
2018
