Sequence of P85A_HUMAN
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EEIGWLNGYN
60 ETTGERGDFP GTYVEYIGRK KISPPTPKPR PPRPLPVAPG SSKTEADVEQ QALTLPDLAE
120 QFAPPDIAPP LLIKLVEAIE KKGLECSTLY RTQSSSNLAE LRQLLDCDTP SVDLEMIDVH
180 VLADAFKRYL LDLPNPVIPA AVYSEMISLA PEVQSSEEYI QLLKKLIRSP SIPHQYWLTL
240 QYLLKHFFKL SQTSSKNLLN ARVLSEIFSP MLFRFSAASS DNTENLIKVI EILISTEWNE
300 RQPAPALPPK PPKPTTVANN GMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA
360 STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFSS VVELINHYRN ESLAQYNPKL
420 DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK
480 RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNYDK LKSRISEIID
540 SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN
600 ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS
660 VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA
720 QQRR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
836810
Skolnik E.Y.,Margolis B.,Mohammadi M.,Lowenstein E.,Fischer R.,Drepps A.,Ullrich A.,Schlessinger J.
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
Cell
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836811
Antonetti D.A.,Algenstaedt P.,Kahn C.R.
Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
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The DNA sequence and comparative analysis of human chromosome 5.
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836817
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Nishimura R.,Li W.,Kashishian A.,Mondino A.,Zhou M.,Cooper J.,Schlessinger J.
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Van Horn D.J.,Myers M.G. Jr.,Backer J.M.
Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
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Vainikka S.,Joukov V.,Wennstrom S.,Bergman M.,Pelicci P.G.,Alitalo K.
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Craparo A.,O'Neill T.J.,Gustafson T.A.
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Gustafson T.A.,He W.,Craparo A.,Schaub C.D.,O'Neill T.J.
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Yokote K.,Margolis B.,Heldin C.H.,Claesson-Welsh L.
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
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836824
Price D.J.,Rivnay B.,Fu Y.,Jiang S.,Avraham S.,Avraham H.
Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
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Braunger J.,Schleithoff L.,Schulz A.S.,Kessler H.,Lammers R.,Ullrich A.,Bartram C.R.,Janssen J.W.
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
Oncogene
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Zhang W.,Sloan-Lancaster J.,Kitchen J.,Trible R.P.,Samelson L.E.
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Cell
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Bruyns E.,Marie-Cardine A.,Kirchgessner H.,Sagolla K.,Shevchenko A.,Mann M.,Autschbach F.,Bensussan A.,Meuer S.,Schraven B.
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Ettenberg S.A.,Keane M.M.,Nau M.M.,Frankel M.,Wang L.-M.,Pierce J.H.,Lipkowitz S.
cbl-b inhibits epidermal growth factor receptor signaling.
Oncogene
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Axelsson L.,Hellberg C.,Melander F.,Smith D.,Zheng L.,Andersson T.
Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase.
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2000
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Sweeney C.,Lai C.,Riese D.J. II,Diamonti A.J.,Cantley L.C.,Carraway K.L. III
Ligand discrimination in signaling through an ErbB4 receptor homodimer.
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Kusch A.,Tkachuk S.,Haller H.,Dietz R.,Gulba D.C.,Lipp M.,Dumler I.
Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction.
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Fang D.,Wang H.-Y.,Fang N.,Altman Y.,Elly C.,Liu Y.-C.
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
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Fang D.,Liu Y.-C.
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836836
Sano H.,Liu S.C.H.,Lane W.S.,Piletz J.E.,Lienhard G.E.
Insulin receptor substrate 4 associates with the protein IRAS.
J. Biol. Chem.
277
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2002
836837
Zhu M.,Janssen E.,Leung K.,Zhang W.
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.
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277
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2002
836838
Linnemann T.,Zheng Y.-H.,Mandic R.,Peterlin B.M.
Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV.
Virology
294
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2002
836839
He Y.,Nakao H.,Tan S.-L.,Polyak S.J.,Neddermann P.,Vijaysri S.,Jacobs B.L.,Katze M.G.
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.
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76
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2002
836840
Tacconelli A.,Farina A.R.,Cappabianca L.,Desantis G.,Tessitore A.,Vetuschi A.,Sferra R.,Rucci N.,Argenti B.,Screpanti I.,Gulino A.,Mackay A.R.
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
Cancer Cell
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347-360
2004
836841
Ronnstrand L.
Signal transduction via the stem cell factor receptor/c-Kit.
Cell. Mol. Life Sci.
61
2535-2548
2004
836842
Laurent C.E.,Smithgall T.E.
The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Exp. Cell Res.
299
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2004
836843
Continolo S.,Baruzzi A.,Majeed M.,Caveggion E.,Fumagalli L.,Lowell C.A.,Berton G.
The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
Exp. Cell Res.
302
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2005
836844
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
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23
94-101
2005
836845
Tsuboi N.,Utsunomiya T.,Roberts R.L.,Ito H.,Takahashi K.,Noda M.,Takahashi T.
The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase.
Biochem. J.
413
193-200
2008
836846
Kaushansky A.,Gordus A.,Budnik B.A.,Lane W.S.,Rush J.,MacBeath G.
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.
Chem. Biol.
15
808-817
2008
836847
Voss M.,Lettau M.,Janssen O.
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
BMC Immunol.
10
53-53
2009
836848
Salazar L.,Kashiwada T.,Krejci P.,Muchowski P.,Donoghue D.,Wilcox W.R.,Thompson L.M.
A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.
Hum. Mol. Genet.
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2009
836849
Eswarakumar V.P.,Lax I.,Schlessinger J.
Cellular signaling by fibroblast growth factor receptors.
Cytokine Growth Factor Rev.
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139-149
2005
836850
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
836851
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
836852
Winnay J.N.,Boucher J.,Mori M.A.,Ueki K.,Kahn C.R.
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Nat. Med.
16
438-445
2010
836853
Ha Y.J.,Seul H.J.,Lee J.R.
Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.
Exp. Mol. Med.
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2011
836854
Wagner M.J.,Smiley J.R.
Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.
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2011
836855
Lin C.,Ear J.,Pavlova Y.,Mittal Y.,Kufareva I.,Ghassemian M.,Abagyan R.,Garcia-Marcos M.,Ghosh P.
Tyrosine phosphorylation of the Galpha-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.
Sci. Signal.
4
0-0
2011
836856
Conley M.E.,Dobbs A.K.,Quintana A.M.,Bosompem A.,Wang Y.D.,Coustan-Smith E.,Smith A.M.,Perez E.E.,Murray P.J.
Agammaglobulinemia and absent B lineage cells in a patient lacking the p85? subunit of PI3K.
J. Exp. Med.
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463-470
2012
836857
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
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2012
836858
Dyment D.A.,Smith A.C.,Alcantara D.,Schwartzentruber J.A.,Basel-Vanagaite L.,Curry C.J.,Temple I.K.,Reardon W.,Mansour S.,Haq M.R.,Gilbert R.,Lehmann O.J.,Vanstone M.R.,Beaulieu C.L.,Majewski J.,Bulman D.E.,O'Driscoll M.,Boycott K.M.,Innes A.M.,Friedman J.,Michaud J.,Bernier F.,Brudno M.,Fernandez B.,Knoppers B.,Samuels M.,Scherer S.
Mutations in PIK3R1 cause SHORT syndrome.
Am. J. Hum. Genet.
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2013
836859
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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2013
836860
Liu X.,Cohen J.I.
Varicella-zoster virus ORF12 protein activates the phosphatidylinositol 3-kinase/Akt pathway to regulate cell cycle progression.
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Cipriano R.,Miskimen K.L.,Bryson B.L.,Foy C.R.,Bartel C.A.,Jackson M.W.
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
Oncotarget
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Deau M.C.,Heurtier L.,Frange P.,Suarez F.,Bole-Feysot C.,Nitschke P.,Cavazzana M.,Picard C.,Durandy A.,Fischer A.,Kracker S.
A human immunodeficiency caused by mutations in the PIK3R1 gene.
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Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
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836864
Lu Y.,Zheng X.,Hu W.,Bian S.,Zhang Z.,Tao D.,Liu Y.,Ma Y.
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
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836865
Liang J.,Chen J.K.,Schreiber S.L.,Clardy J.
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Nolte R.T.,Eck M.J.,Schlessinger J.,Shoelson S.E.,Harrison S.C.
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
Nat. Struct. Biol.
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Musacchio A.,Cantley L.C.,Harrison S.C.
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
Proc. Natl. Acad. Sci. U.S.A.
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836868
Pauptit R.A.,Dennis C.A.,Derbyshire D.J.,Breeze A.L.,Weston S.A.,Rowsell S.,Murshudov G.N.
NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.
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836869
Koyama S.,Yu H.,Dalgarno D.C.,Shin T.B.,Zydowsky L.D.,Schreiber S.L.
Structure of the PI3K SH3 domain and analysis of the SH3 family.
Cell
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1993
836870
Renzoni D.A.,Pugh D.J.,Siligardi G.,Das P.,Morton C.J.,Rossi C.,Waterfield M.D.,Campbell I.D.,Ladbury J.E.
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry
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836871
Breeze A.L.,Kara B.V.,Barratt D.G.,Anderson M.,Smith J.C.,Luke R.W.,Best J.R.,Cartlidge S.A.
Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.
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836872
Miled N.,Yan Y.,Hon W.C.,Perisic O.,Zvelebil M.,Inbar Y.,Schneidman-Duhovny D.,Wolfson H.J.,Backer J.M.,Williams R.L.
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
Science
317
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2007
836873
Huang C.-H.,Mandelker D.,Schmidt-Kittler O.,Samuels Y.,Velculescu V.E.,Kinzler K.W.,Vogelstein B.,Gabelli S.B.,Amzel L.M.
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science
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836874
Mandelker D.,Gabelli S.B.,Schmidt-Kittler O.,Zhu J.,Cheong I.,Huang C.H.,Kinzler K.W.,Vogelstein B.,Amzel L.M.
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.
Proc. Natl. Acad. Sci. U.S.A.
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836875
Batra-Safferling R.,Granzin J.,Modder S.,Hoffmann S.,Willbold D.
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Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.
Diabetes
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836877
Baynes K.C.R.,Beeton C.A.,Panayotou G.,Stein R.,Soos M.,Hansen T.,Simpson H.,O'Rahilly S.,Shepherd P.R.,Whitehead J.P.
Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.
Diabetologia
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Thauvin-Robinet C.,Auclair M.,Duplomb L.,Caron-Debarle M.,Avila M.,St-Onge J.,Le Merrer M.,Le Luyer B.,Heron D.,Mathieu-Dramard M.,Bitoun P.,Petit J.M.,Odent S.,Amiel J.,Picot D.,Carmignac V.,Thevenon J.,Callier P.,Laville M.,Reznik Y.,Fagour C.,Nunes M.L.,Capeau J.,Lascols O.,Huet F.,Faivre L.,Vigouroux C.,Riviere J.B.
PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy.
Am. J. Hum. Genet.
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Chudasama K.K.,Winnay J.,Johansson S.,Claudi T.,Konig R.,Haldorsen I.,Johansson B.,Woo J.R.,Aarskog D.,Sagen J.V.,Kahn C.R.,Molven A.,Njolstad P.R.
SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.
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2013
