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Sequence of DCK_HUMAN

EC Number:2.7.1.74

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
deoxycytidine kinase
P27707
Homo sapiens
260
30519
Reaction
NTP + deoxycytidine = NDP + dCMP
Other sequences found for EC No. 2.7.1.74

EC Number:2.7.1.76

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2'-deoxyadenosine kinase
P27707
Homo sapiens
260
30519
Reaction
ATP + 2'-deoxyadenosine = ADP + dAMP
Other sequences found for EC No. 2.7.1.76

EC Number:2.7.1.113

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
deoxyguanosine kinase
P27707
Homo sapiens
260
30519
Reaction
ATP + deoxyguanosine = ADP + dGMP
Other sequences found for EC No. 2.7.1.113

General information:

Sequence
show sequence in fasta format
  0 MATPPKRSCP SFSASSEGTR IKKISIEGNI AAGKSTFVNI LKQLCEDWEV VPEPVARWCN
 60 VQSTQDEFEE LTMSQKNGGN VLQMMYEKPE RWSFTFQTYA CLSRIRAQLA SLNGKLKDAE
120 KPVLFFERSV YSDRYIFASN LYESECMNET EWTIYQDWHD WMNNQFGQSL ELDGIIYLQA
180 TPETCLHRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE
240 DFKDKYESLV EKVKEFLSTL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
151529
Chottiner E.G.,Shewach D.S.,Datta N.S.,Ashcraft E.,Gribbin D.,Ginsburg D.,Fox I.H.,Mitchell B.S.
Cloning and expression of human deoxycytidine kinase cDNA.
Proc. Natl. Acad. Sci. U.S.A.
88
1531-1535
1991
151530
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
151534
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
151535
Eriksson S.,Cederlund E.,Bergman T.,Joernvall H.,Bohman C.
Characterization of human deoxycytidine kinase. Correlation with cDNA sequences.
FEBS Lett.
280
363-366
1991
151536
Johansson M.,Brismar S.,Karlsson A.
Human deoxycytidine kinase is located in the cell nucleus.
Proc. Natl. Acad. Sci. U.S.A.
94
11941-11945
1997
151537
Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science
316
1160-1166
2007
151538
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
151539
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
151540
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
151541
Smal C.,Vertommen D.,Amsailale R.,Arts A.,Degand H.,Morsomme P.,Rider M.H.,Neste E.V.,Bontemps F.
Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity.
Arch. Biochem. Biophys.
502
44-52
2010
151542
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
151543
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
151544
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
151545
Sabini E.,Ort S.,Monnerjahn C.,Konrad M.,Lavie A.
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy.
Nat. Struct. Biol.
10
513-519
2003
151546
Zhang Y.,Secrist J.A. III,Ealick S.E.
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.
Acta Crystallogr. D
62
133-139
2006
151547
Sabini E.,Hazra S.,Konrad M.,Lavie A.
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.
J. Med. Chem.
50
3004-3014
2007
151548
Sabini E.,Hazra S.,Ort S.,Konrad M.,Lavie A.
Structural basis for substrate promiscuity of dCK.
J. Mol. Biol.
378
607-621
2008
151549
Hazra S.,Sabini E.,Ort S.,Konrad M.,Lavie A.
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.
Biochemistry
48
1256-1263
2009
151550
Jessop T.C.,Tarver J.E.,Carlsen M.,Xu A.,Healy J.P.,Heim-Riether A.,Fu Q.,Taylor J.A.,Augeri D.J.,Shen M.,Stouch T.R.,Swanson R.V.,Tari L.W.,Hunter M.,Hoffman I.,Keyes P.E.,Yu X.C.,Miranda M.,Liu Q.,Swaffield J.C.,David Kimball S.,Nouraldeen A.,Wilson A.G.,Foushee A.M.,Jhaver K.,Finch R.,Anderson S.,Oravecz T.,Carson K.G.
Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg. Med. Chem. Lett.
19
6784-6787
2009
151551
Hazra S.,Ort S.,Konrad M.,Lavie A.
Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues.
Biochemistry
49
6784-6790
2010
151552
Hazra S.,Konrad M.,Lavie A.
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.
J. Med. Chem.
53
5792-5800
2010