Sequence of VPS34_YEAST
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphatidylinositol 3-kinase
P22543
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
875
100921
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
General information:
Sequence
0 MSLNNITFCV SQDLDVPLKV KIKSLEGHKP LLKPSQKILN PELMLIGSNV FPSSDLIVSL
60 QVFDKERNRN LTLPIYTPYI PFRNSRTWDY WLTLPIRIKQ LTFSSHLRII LWEYNGSKQI
120 PFFNLETSIF NLKDCTLKRG FESLKFRYDV IDHCEVVTDN KDQENLNKYF QGEFTRLPWL
180 DEITISKLRK QRENRTWPQG TFVLNLEFPM LELPVVFIER EIMNTQMNIP TLKNNPGLST
240 DLREPNRNDP QIKISLGDKY HSTLKFYDPD QPNNDPIEEK YRRLERASKN ANLDKQVKPD
300 IKKRDYLNKI INYPPGTKLT AHEKGSIWKY RYYLMNNKKA LTKLLQSTNL REESERVEVL
360 ELMDSWAEID IDDALELLGS TFKNLSVRSY AVNRLKKASD KELELYLLQL VEAVCFENLS
420 TFSDKSNSEF TIVDAVSSQK LSGDSMLLST SHANQKLLKS ISSESETSGT ESLPIVISPL
480 AEFLIRRALV NPRLGSFFYW YLKSESEDKP YLDQILSSFW SRLDKKSRNI LNDQVRLINV
540 LRECCETIKR LKDTTAKKME LLVHLLETKV RPLVKVRPIA LPLDPDVLIC DVCPETSKVF
600 KSSLSPLKIT FKTTLNQPYH LMFKVGDDLR QDQLVVQIIS LMNELLKNEN VDLKLTPYKI
660 LATGPQEGAI EFIPNDTLAS ILSKYHGILG YLKLHYPDEN ATLGVQGWVL DNFVKSCAGY
720 CVITYILGVG DRHLDNLLVT PDGHFFHADF GYILGQDPKP FPPLMKLPPQ IIEAFGGAES
780 SNYDKFRSYC FVAYSILRRN AGLILNLFEL MKTSNIPDIR IDPNGAILRV RERFNLNMSE
840 EDATVHFQNL INDSVNALLP IVIDHLHNLA QYWRT
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
754632
Herman P.K.,Emr S.D.
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.
Mol. Cell. Biol.
10
6742-6754
1990
754633
Johnston M.,Hillier L.W.,Riles L.,Albermann K.,Andre B.,Ansorge W.,Benes V.,Brueckner M.,Delius H.,Dubois E.,Duesterhoeft A.,Entian K.-D.,Floeth M.,Goffeau A.,Hebling U.,Heumann K.,Heuss-Neitzel D.,Hilbert H.,Hilger F.,Kleine K.,Koetter P.,Louis E.J.,Messenguy F.,Mewes H.-W.,Miosga T.,Moestl D.,Mueller-Auer S.,Nentwich U.,Obermaier B.,Piravandi E.,Pohl T.M.,Portetelle D.,Purnelle B.,Rechmann S.,Rieger M.,Rinke M.,Rose M.,Scharfe M.,Scherens B.,Scholler P.,Schwager C.,Schwarz S.,Underwood A.P.,Urrestarazu L.A.,Vandenbol M.,Verhasselt P.,Vierendeels F.,Voet M.,Volckaert G.,Voss H.,Wambutt R.,Wedler E.,Wedler H.,Zimmermann F.K.,Zollner A.,Hani J.,Hoheisel J.D.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Nature
387
87-90
1997
754634
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
754635
Robinson J.S.,Klionsky D.J.,Banta L.M.,Emr S.D.
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.
Mol. Cell. Biol.
8
4936-4948
1988
754636
Auger K.R.,Carpenter C.L.,Cantley L.C.,Varticovski L.
Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.
J. Biol. Chem.
264
20181-20184
1989
754637
Stack J.H.,Herman P.K.,Schu P.V.,Emr S.D.
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.
EMBO J.
12
2195-2204
1993
754638
Schu P.V.,Takegawa K.,Fry M.J.,Stack J.H.,Waterfield M.D.,Emr S.D.
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.
Science
260
88-91
1993
754639
Stack J.H.,Emr S.D.
Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.
J. Biol. Chem.
269
31552-31562
1994
754640
Munn A.L.,Riezman H.
Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.
J. Cell Biol.
127
373-386
1994
754641
Kihara A.,Noda T.,Ishihara N.,Ohsumi Y.
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.
J. Cell Biol.
152
519-530
2001
754642
Takahashi T.,Shimoi H.,Ito K.
Identification of genes required for growth under ethanol stress using transposon mutagenesis in Saccharomyces cerevisiae.
Mol. Genet. Genomics
265
1112-1119
2001
754643
Burda P.,Padilla S.M.,Sarkar S.,Emr S.D.
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.
J. Cell Sci.
115
3889-3900
2002
754644
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
754645
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
754646
Araki Y.,Ku W.C.,Akioka M.,May A.I.,Hayashi Y.,Arisaka F.,Ishihama Y.,Ohsumi Y.
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.
J. Cell Biol.
203
299-313
2013
754647
Kim A.,Cunningham K.W.
A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress.
Mol. Biol. Cell
26
4631-4645
2015
754648
Tanigawa M.,Maeda T.
An In Vitro TORC1 Kinase Assay That Recapitulates the Gtr-Independent Glutamine-Responsive TORC1 Activation Mechanism on Yeast Vacuoles.
Mol. Cell. Biol.
37
0-0
2017
754649
Ukai H.,Araki Y.,Kira S.,Oikawa Y.,May A.I.,Noda T.
Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane.
PLoS Genet.
14
0-0
2018
