Sequence of ACOHC_HUMAN
EC Number:4.2.1.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
citrate = cis-aconitate + H2O
Other sequences found for EC No. 4.2.1.3
General information:
Sequence
0 MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC DEFLVKKQDI
60 ENILHWNVTQ HKNIEVPFKP ARVILQDFTG VPAVVDFAAM RDAVKKLGGD PEKINPVCPA
120 DLVIDHSIQV DFNRRADSLQ KNQDLEFERN RERFEFLKWG SQAFHNMRII PPGSGIIHQV
180 NLEYLARVVF DQDGYYYPDS LVGTDSHTTM IDGLGILGWG VGGIEAEAVM LGQPISMVLP
240 QVIGYRLMGK PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI ADRATIANMC
300 PEYGATAAFF PVDEVSITYL VQTGRDEEKL KYIKKYLQAV GMFRDFNDPS QDPDFTQVVE
360 LDLKTVVPCC SGPKRPQDKV AVSDMKKDFE SCLGAKQGFK GFQVAPEHHN DHKTFIYDNT
420 EFTLAHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVDAG LNVMPYIKTS LSPGSGVVTY
480 YLQESGVMPY LSQLGFDVVG YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG VLSGNRNFEG
540 RVHPNTRANY LASPPLVIAY AIAGTIRIDF EKEPLGVNAK GQQVFLKDIW PTRDEIQAVE
600 RQYVIPGMFK EVYQKIETVN ESWNALATPS DKLFFWNSKS TYIKSPPFFE NLTLDLQPPK
660 SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG LTPREFNSYG SRRGNDAVMA
720 RGTFANIRLL NRFLNKQAPQ TIHLPSGEIL DVFDAAERYQ QAGLPLIVLA GKEYGAGSSR
780 DWAAKGPFLL GIKAVLAESY ERIHRSNLVG MGVIPLEYLP GENADALGLT GQERYTIIIP
840 ENLKPQMKVQ VKLDTGKTFQ AVMRFDTDVE LTYFLNGGIL NYMIRKMAK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1153591
Hirling H.,Emery-Goodman A.,Thompson N.,Neupert B.,Seiser C.,Kuehn L.
Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
Nucleic Acids Res.
20
33-39
1992
1153593
Humphray S.J.,Oliver K.,Hunt A.R.,Plumb R.W.,Loveland J.E.,Howe K.L.,Andrews T.D.,Searle S.,Hunt S.E.,Scott C.E.,Jones M.C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Ashwell R.I.S.,Babbage A.K.,Babbage S.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beasley H.,Beasley O.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Chen Y.,Clarke G.,Clark S.Y.,Clee C.M.,Clegg S.,Collier R.E.,Corby N.,Crosier M.,Cummings A.T.,Davies J.,Dhami P.,Dunn M.,Dutta I.,Dyer L.W.,Earthrowl M.E.,Faulkner L.,Fleming C.J.,Frankish A.,Frankland J.A.,French L.,Fricker D.G.,Garner P.,Garnett J.,Ghori J.,Gilbert J.G.R.,Glison C.,Grafham D.V.,Gribble S.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Guy J.,Hall R.E.,Hammond S.,Harley J.L.,Harrison E.S.I.,Hart E.A.,Heath P.D.,Henderson C.D.,Hopkins B.L.,Howard P.J.,Howden P.J.,Huckle E.,Johnson C.,Johnson D.,Joy A.A.,Kay M.,Keenan S.,Kershaw J.K.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.,Lloyd D.M.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,McLaren S.,McLay K.E.,McMurray A.,Milne S.,Nickerson T.,Nisbett J.,Nordsiek G.,Pearce A.V.,Peck A.I.,Porter K.M.,Pandian R.,Pelan S.,Phillimore B.,Povey S.,Ramsey Y.,Rand V.,Scharfe M.,Sehra H.K.,Shownkeen R.,Sims S.K.,Skuce C.D.,Smith M.,Steward C.A.,Swarbreck D.,Sycamore N.,Tester J.,Thorpe A.,Tracey A.,Tromans A.,Thomas D.W.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Williams S.A.,Wilming L.,Wray P.W.,Young L.,Ashurst J.L.,Coulson A.,Blocker H.,Durbin R.M.,Sulston J.E.,Hubbard T.,Jackson M.J.,Bentley D.R.,Beck S.,Rogers J.,Dunham I.
DNA sequence and analysis of human chromosome 9.
Nature
429
369-374
2004
1153595
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1153596
Rouault T.A.,Tang C.K.,Kaptain S.,Burgess W.H.,Haile D.J.,Samaniego F.,McBride O.W.,Harford J.B.,Klausner R.D.
Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein.
Proc. Natl. Acad. Sci. U.S.A.
87
7958-7962
1990
1153597
Hentze M.W.,Argos P.
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
Nucleic Acids Res.
19
1739-1740
1991
1153598
Kaptain S.,Downey W.E.,Tang C.K.,Philpott C.,Haile D.J.,Orloff D.G.,Harford J.B.,Rouault T.A.,Klausner R.D.
A regulated RNA binding protein also possesses aconitase activity.
Proc. Natl. Acad. Sci. U.S.A.
88
10109-10113
1991
1153599
Haile D.J.,Rouault T.A.,Harford J.B.,Kennedy M.C.,Blondin G.A.,Beinert H.,Klausner R.D.
Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.
Proc. Natl. Acad. Sci. U.S.A.
89
11735-11739
1992
1153600
Philpott C.C.,Klausner R.D.,Rouault T.A.
The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.
Proc. Natl. Acad. Sci. U.S.A.
91
7321-7325
1994
1153601
Vashisht A.A.,Zumbrennen K.B.,Huang X.,Powers D.N.,Durazo A.,Sun D.,Bhaskaran N.,Persson A.,Uhlen M.,Sangfelt O.,Spruck C.,Leibold E.A.,Wohlschlegel J.A.
Control of iron homeostasis by an iron-regulated ubiquitin ligase.
Science
326
718-721
2009
1153602
Salahudeen A.A.,Thompson J.W.,Ruiz J.C.,Ma H.-W.,Kinch L.N.,Li Q.,Grishin N.V.,Bruick R.K.
An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis.
Science
326
722-726
2009
1153603
Condo I.,Malisan F.,Guccini I.,Serio D.,Rufini A.,Testi R.
Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.
Hum. Mol. Genet.
19
1221-1229
2010
1153604
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1153605
Stehling O.,Mascarenhas J.,Vashisht A.A.,Sheftel A.D.,Niggemeyer B.,Roesser R.,Pierik A.J.,Wohlschlegel J.A.,Lill R.
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Cell Metab.
18
187-198
2013
1153606
Stehling O.,Mascarenhas J.,Vashisht A.A.,Sheftel A.D.,Niggemeyer B.,Roesser R.,Pierik A.J.,Wohlschlegel J.A.,Lill R.
Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.
Cell Metab.
27
263-263
2018
1153607
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1153608
Dupuy J.,Volbeda A.,Carpentier P.,Darnault C.,Moulis J.-M.,Fontecilla-Camps J.C.
Crystal structure of human iron regulatory protein 1 as cytosolic aconitase.
Structure
14
129-139
2006
1153609
de Ligt J.,Willemsen M.H.,van Bon B.W.,Kleefstra T.,Yntema H.G.,Kroes T.,Vulto-van Silfhout A.T.,Koolen D.A.,de Vries P.,Gilissen C.,del Rosario M.,Hoischen A.,Scheffer H.,de Vries B.B.,Brunner H.G.,Veltman J.A.,Vissers L.E.
Diagnostic exome sequencing in persons with severe intellectual disability.
N. Engl. J. Med.
367
1921-1929
2012
