Sequence of TYPH_HUMAN
EC Number:2.4.2.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Other sequences found for EC No. 2.4.2.4
General information:
Sequence
0 MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA
60 VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG
120 VGDKVSLVLA PALAACGCKV PMISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA
180 GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA
240 VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP
300 DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL
360 CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG
420 AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP
480 QQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
496886
Ishikawa F.,Miyazono K.,Hellman U.,Drexler H.,Wernstedt C.,Hagiwara K.,Usuki K.,Takaku F.,Risau W.,Heldin C.-H.
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
Nature
338
557-562
1989
496887
Finnis C.,Goodey A.,Courtney M.,Sleep D.
Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae.
Yeast
8
57-60
1992
496889
Dunham I.,Hunt A.R.,Collins J.E.,Bruskiewich R.,Beare D.M.,Clamp M.,Smink L.J.,Ainscough R.,Almeida J.P.,Babbage A.K.,Bagguley C.,Bailey J.,Barlow K.F.,Bates K.N.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Buck D.,Burgess J.,Burrill W.D.,Burton J.,Carder C.,Carter N.P.,Chen Y.,Clark G.,Clegg S.M.,Cobley V.E.,Cole C.G.,Collier R.E.,Connor R.,Conroy D.,Corby N.R.,Coville G.J.,Cox A.V.,Davis J.,Dawson E.,Dhami P.D.,Dockree C.,Dodsworth S.J.,Durbin R.M.,Ellington A.G.,Evans K.L.,Fey J.M.,Fleming K.,French L.,Garner A.A.,Gilbert J.G.R.,Goward M.E.,Grafham D.V.,Griffiths M.N.D.,Hall C.,Hall R.E.,Hall-Tamlyn G.,Heathcott R.W.,Ho S.,Holmes S.,Hunt S.E.,Jones M.C.,Kershaw J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.F.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Martyn I.D.,Mashreghi-Mohammadi M.,Matthews L.H.,Mccann O.T.,Mcclay J.,Mclaren S.,McMurray A.A.,Milne S.A.,Mortimore B.J.,Odell C.N.,Pavitt R.,Pearce A.V.,Pearson D.,Phillimore B.J.C.T.,Phillips S.H.,Plumb R.W.,Ramsay H.,Ramsey Y.,Rogers L.,Ross M.T.,Scott C.E.,Sehra H.K.,Skuce C.D.,Smalley S.,Smith M.L.,Soderlund C.,Spragon L.,Steward C.A.,Sulston J.E.,Swann R.M.,Vaudin M.,Wall M.,Wallis J.M.,Whiteley M.N.,Willey D.L.,Williams L.,Williams S.A.,Williamson H.,Wilmer T.E.,Wilming L.,Wright C.L.,Hubbard T.,Bentley D.R.,Beck S.,Rogers J.,Shimizu N.,Minoshima S.,Kawasaki K.,Sasaki T.,Asakawa S.,Kudoh J.,Shintani A.,Shibuya K.,Yoshizaki Y.,Aoki N.,Mitsuyama S.,Roe B.A.,Chen F.,Chu L.,Crabtree J.,Deschamps S.,Do A.,Do T.,Dorman A.,Fang F.,Fu Y.,Hu P.,Hua A.,Kenton S.,Lai H.,Lao H.I.,Lewis J.,Lewis S.,Lin S.-P.,Loh P.,Malaj E.,Nguyen T.,Pan H.,Phan S.,Qi S.,Qian Y.,Ray L.,Ren Q.,Shaull S.,Sloan D.,Song L.,Wang Q.,Wang Y.,Wang Z.,White J.,Willingham D.,Wu H.,Yao Z.,Zhan M.,Zhang G.,Chissoe S.,Murray J.,Miller N.,Minx P.,Fulton R.,Johnson D.,Bemis G.,Bentley D.,Bradshaw H.,Bourne S.,Cordes M.,Du Z.,Fulton L.,Goela D.,Graves T.,Hawkins J.,Hinds K.,Kemp K.,Latreille P.,Layman D.,Ozersky P.,Rohlfing T.,Scheet P.,Walker C.,Wamsley A.,Wohldmann P.,Pepin K.,Nelson J.,Korf I.,Bedell J.A.,Hillier L.W.,Mardis E.,Waterston R.,Wilson R.,Emanuel B.S.,Shaikh T.,Kurahashi H.,Saitta S.,Budarf M.L.,McDermid H.E.,Johnson A.,Wong A.C.C.,Morrow B.E.,Edelmann L.,Kim U.J.,Shizuya H.,Simon M.I.,Dumanski J.P.,Peyrard M.,Kedra D.,Seroussi E.,Fransson I.,Tapia I.,Bruder C.E.,O'Brien K.P.,Wilkinson P.,Bodenteich A.,Hartman K.,Hu X.,Khan A.S.,Lane L.,Tilahun Y.,Wright H.
The DNA sequence of human chromosome 22.
Nature
402
489-495
1999
496890
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
496891
Furukawa T.,Yoshimura A.,Sumizawa T.,Haraguchi M.,Akiyama S.,Fukui K.,Yamada Y.
Angiogenic factor.
Nature
356
668-668
1992
496892
Asai K.,Nakanishi K.,Isobe I.,Eksioglu Y.Z.,Hirano A.,Hama K.,Miyamoto T.,Kato T.
Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.
J. Biol. Chem.
267
20311-20316
1992
496893
Usuki K.,Saras J.,Waltenberger J.,Miyazono K.,Pierce G.,Thomason A.,Heldin C.-H.
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
Biochem. Biophys. Res. Commun.
184
1311-1316
1992
496894
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
496895
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
496896
Norman R.A.,Barry S.T.,Bate M.,Breed J.,Colls J.G.,Ernill R.J.,Luke R.W.,Minshull C.A.,McAlister M.S.,McCall E.J.,McMiken H.H.,Paterson D.S.,Timms D.,Tucker J.A.,Pauptit R.A.
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.
Structure
12
75-84
2004
496897
El Omari K.,Bronckaers A.,Liekens S.,Perez-Perez M.J.,Balzarini J.,Stammers D.K.
Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.
Biochem. J.
399
199-204
2006
496898
Mitsiki E.,Papageorgiou A.C.,Iyer S.,Thiyagarajan N.,Prior S.H.,Sleep D.,Finnis C.,Acharya K.R.
Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.
Biochem. Biophys. Res. Commun.
386
666-670
2009
496899
Nishino I.,Spinazzola A.,Hirano M.
Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.
Science
283
689-692
1999
496900
Gamez J.,Ferreiro C.,Accarino M.L.,Guarner L.,Tadesse S.,Marti R.A.,Andreu A.L.,Raguer N.,Cervera C.,Hirano M.
Phenotypic variability in a Spanish family with MNGIE.
Neurology
59
455-457
2002
