Sequence of HXK1_HUMAN

hexokinase

P19367

917

102486

45709

Nishi S.,Seino S.,Bell G.I.

Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous.

Biochem. Biophys. Res. Commun.

157

937-943

1988

45710

Ruzzo A.,Andreoni F.,Magnani M.

Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region.

Biochem. J.

331

607-613

1998

45711

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

429

375-381

2004

45712

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

45713

Andreoni F.,Ruzzo A.,Magnani M.

Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA.

Biochim. Biophys. Acta

1493

19-26

2000

45716

Magnani M.,Serafini G.,Bianchi M.,Casabianca A.,Stocchi V.

Human hexokinase type I microheterogeneity is due to different amino-terminal sequences.

J. Biol. Chem.

266

502-505

1991

45717

Magnani M.,Bianchi M.,Casabianca A.,Stocchi V.,Daniele A.,Altruda F.,Ferrone M.,Silengo L.

A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates.

Biochem. J.

285

193-199

1992

45718

Murakami K.,Piomelli S.

Identification of the cDNA for human red blood cell-specific hexokinase isozyme.

Blood

89

762-766

1997

45719

Aleshin A.E.,Zeng C.,Fromm H.J.,Honatko R.B.

Crystallization and preliminary X-ray analysis of human brain hexokinase.

FEBS Lett.

391

9-10

1996

45720

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

45721

Hantke J.,Chandler D.,King R.,Wanders R.J.,Angelicheva D.,Tournev I.,McNamara E.,Kwa M.,Guergueltcheva V.,Kaneva R.,Baas F.,Kalaydjieva L.

A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR).

Eur. J. Hum. Genet.

17

1606-1614

2009

45722

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

45723

Lau E.,Kluger H.,Varsano T.,Lee K.,Scheffler I.,Rimm D.L.,Ideker T.,Ronai Z.A.

PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.

Cell

148

543-555

2012

45724

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

45725

Wolf A.J.,Reyes C.N.,Liang W.,Becker C.,Shimada K.,Wheeler M.L.,Cho H.C.,Popescu N.I.,Coggeshall K.M.,Arditi M.,Underhill D.M.

Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan.

Cell

166

624-636

2016

45726

Aleshin A.E.,Zeng C.,Bourenkov G.P.,Bartunik H.D.,Fromm H.J.,Honzatko R.B.

The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.

Structure

6

39-50

1998

45727

Aleshin A.E.,Zeng C.,Bartunik H.D.,Fromm H.J.,Honzatko R.B.

Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.

J. Mol. Biol.

282

345-357

1998

45728

Rosano C.,Sabini E.,Rizzi M.,Deriu D.,Murshudov G.,Bianchi M.,Serafini G.,Magnani M.,Bolognesi M.

Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.

Structure

7

1427-1437

1999

45729

Aleshin A.E.,Kirby C.,Liu X.,Bourenkov G.P.,Bartunik H.D.,Fromm H.J.,Honzatko R.B.

Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.

J. Mol. Biol.

296

1001-1015

2000

45730

Bianchi M.,Magnani M.

Hexokinase mutations that produce nonspherocytic hemolytic anemia.

Blood Cells Mol. Dis.

21

2-8

1995

45731

van Wijk R.,Rijksen G.,Huizinga E.G.,Nieuwenhuis H.K.,van Solinge W.W.

HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.

Blood

101

345-347

2003

45732

Sullivan L.S.,Koboldt D.C.,Bowne S.J.,Lang S.,Blanton S.H.,Cadena E.,Avery C.E.,Lewis R.A.,Webb-Jones K.,Wheaton D.H.,Birch D.G.,Coussa R.,Ren H.,Lopez I.,Chakarova C.,Koenekoop R.K.,Garcia C.A.,Fulton R.S.,Wilson R.K.,Weinstock G.M.,Daiger S.P.

A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa.

Invest. Ophthalmol. Vis. Sci.

55

7147-7158

2014

45733

Wang F.,Wang Y.,Zhang B.,Zhao L.,Lyubasyuk V.,Wang K.,Xu M.,Li Y.,Wu F.,Wen C.,Bernstein P.S.,Lin D.,Zhu S.,Wang H.,Zhang K.,Chen R.

A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa.

Invest. Ophthalmol. Vis. Sci.

55

7159-7164

2014

45734

Okur V.,Cho M.T.,van Wijk R.,van Oirschot B.,Picker J.,Coury S.A.,Grange D.,Manwaring L.,Krantz I.,Muraresku C.C.,Hulick P.J.,May H.,Pierce E.,Place E.,Bujakowska K.,Telegrafi A.,Douglas G.,Monaghan K.G.,Begtrup A.,Wilson A.,Retterer K.,Anyane-Yeboa K.,Chung W.K.

De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment.

Eur. J. Hum. Genet.

27

1081-1089

2019