Sequence of TPH1_HUMAN
EC Number:1.14.16.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other sequences found for EC No. 1.14.16.4
General information:
Sequence
0 MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF
60 EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED GMETVPWFPK KISDLDHCAN
120 RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE
180 LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD
240 FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA
300 SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK VKPFDPKITC
360 KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDTKSITSA
420 MNELQHDLDV VSDALAKVSR KPSI
Download this sequence
in fasta formatDownload all sequences for 1.14.16.4
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
110698
Boulalard S.,Darmon M.C.,Ganem Y.,Launay J.-M.,Mallet J.
Complete coding sequence of human tryptophan hydroxylase.
Nucleic Acids Res.
18
4257-4257
1990
110699
Tipper J.P.,Citron B.A.,Ribeiro P.,Kaufman S.
Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli.
Arch. Biochem. Biophys.
315
445-453
1994
110701
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
110702
Wang G.A.,Coon S.L.,Kaufman S.
Alternative splicing at the 3'-cDNA of human tryptophan hydroxylase.
J. Neurochem.
71
1769-1772
1998
110703
Wang L.,Erlandsen H.,Haavik J.,Knappskog P.M.,Stevens R.C.
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
Biochemistry
41
12569-12574
2002
