Sequence of DHI1_RAT
EC Number:1.1.1.B40
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
Other sequences found for EC No. 1.1.1.B40
EC Number:1.1.1.146
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
Other sequences found for EC No. 1.1.1.146
EC Number:1.1.1.201
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
Other sequences found for EC No. 1.1.1.201
General information:
Sequence
0 MKKYLLPVLV LCLGYYYSTN EEFRPEMLQG KKVIVTGASK GIGREMAYHL SKMGAHVVLT
60 ARSEEGLQKV VSRCLELGAA SAHYIAGTME DMAFAERFVV EAGKLLGGLD MLILNHITQT
120 TMSLFHDDIH SVRRSMEVNF LSYVVLSTAA LPMLKQSNGS IAIISSMAGK MTQPLIASYS
180 ASKFALDGFF STIRKEHLMT KVNVSITLCV LGFIDTETAL KETSGIILSQ AAPKEECALE
240 IIKGTVLRKD EVYYDKSSWT PLLLGNPGRR IMEFLSLRSY NRDLFVSN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1049939
Agarwal A.K.,Monder C.,Eckstein B.,White P.C.
Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.
J. Biol. Chem.
264
18939-18943
1989
1049940
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1049941
Moisan M.P.,Edwards C.R.,Seckl J.R.
Differential promoter usage by the rat 11 beta-hydroxysteroid dehydrogenase gene.
Mol. Endocrinol.
6
1082-1087
1992
1049942
Williams L.J.S.,Lyons V.,MacLeod I.,Rajan V.,Darlington G.J.,Poli V.,Seckl J.R.,Chapman K.E.
C/EBP regulates hepatic transcription of 11beta-hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways.
J. Biol. Chem.
275
30232-30239
2000
1049943
Nobel C.S.I.,Dunas F.,Abrahmsen L.B.
Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.
Protein Expr. Purif.
26
349-356
2002
1049944
Krozowski Z.,Obeyesekere V.,Smith R.,Mercer W.
Tissue-specific expression of an 11 beta-hydroxysteroid dehydrogenase with a truncated N-terminal domain. A potential mechanism for differential intracellular localization within mineralocorticoid target cells.
J. Biol. Chem.
267
2569-2574
1992
1049945
Monder C.,Shackleton C.H.L.,Bradlow H.L.,New M.I.,Stoner E.,Iohan F.,Lakshmi V.
The syndrome of apparent mineralocorticoid excess: its association with 11 beta-dehydrogenase and 5 beta-reductase deficiency and some consequences for corticosteroid metabolism.
J. Clin. Endocrinol. Metab.
63
550-557
1986
1049946
Moisan M.P.,Seckl J.R.,Edwards C.R.
11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex.
Endocrinology
127
1450-1455
1990
1049947
Rajan V.,Edwards C.R.,Seckl J.R.
11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity.
J. Neurosci.
16
65-70
1996
1049948
Schweizer R.A.S.,Zuercher M.,Balazs Z.,Dick B.,Odermatt A.
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.
J. Biol. Chem.
279
18415-18424
2004
1049949
Odermatt A.,Da Cunha T.,Penno C.A.,Chandsawangbhuwana C.,Reichert C.,Wolf A.,Dong M.,Baker M.E.
Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11beta-hydroxysteroid dehydrogenase 1.
Biochem. J.
436
621-629
2011
1049950
Obeid J.,White P.C.
Tyr-179 and Lys-183 are essential for enzymatic activity of 11 beta-hydroxysteroid dehydrogenase.
Biochem. Biophys. Res. Commun.
188
222-227
1992
