Sequence of AATA_PENCH
EC Number:2.3.1.164
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate
Other sequences found for EC No. 2.3.1.164
General information:
Sequence
0 MLHILCQGTP FEIGYEHGSA AKAVIARSID FAVDLIRGKT KKTDEELKQV LSQLGRVIEE
60 RWPKYYEEIR GIAKGAERDV SEIVMLNTRT EFAYGLKAAR DGCTTAYCQL PNGALQGQNW
120 DFFSATKENL IRLTIRQAGL PTIKFITEAG IIGKVGFNSA GVAVNYNALH LQGLRPTGVP
180 SHIALRIALE STSPSQAYDR IVEQGGMAAS AFIMVGNGHE AFGLEFSPTS IRKQVLDANG
240 RMVHTNHCLL QHGKNEKELD PLPDSWNRHQ RMEFLLDGFD GTKQAFAQLW ADEDNYPFSI
300 CRAYEEGKSR GATLFNIIYD HARREATVRL GRPTNPDEMF VMRFDEEDER SALNARL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
385429
Barredo J.L.,van Solingen P.,Diez B.,Alvarez E.,Cantoral J.M.,Kattevilder A.,Smaal E.B.,Groenen M.A.M.,Veenstra A.E.,Martin J.F.
Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-acid-acyltransferase gene of Penicillium chrysogenum.
Gene
83
291-300
1989
385430
Tobin M.B.,Fleming M.D.,Skatrud P.L.,Miller J.R.
Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli.
J. Bacteriol.
172
5908-5914
1990
385431
Whiteman P.A.,Abraham E.P.,Baldwin J.E.,Fleming M.D.,Schofield C.J.,Sutherland J.D.,Willis A.C.
Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans.
FEBS Lett.
262
342-344
1990
385432
Smith D.J.,Burnham M.K.,Edwards J.,Earl A.J.,Turner G.
Cloning and heterologous expression of the penicillin biosynthetic gene cluster from penicillum chrysogenum.
Biotechnology (N.Y.)
8
39-41
1990
385433
Aplin R.T.,Baldwin J.E.,Roach P.L.,Robinson C.V.,Schofield C.J.
Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
Biochem. J.
294
357-363
1993
385434
Garcia-Estrada C.,Vaca I.,Fierro F.,Sjollema K.,Veenhuis M.,Martin J.F.
The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing.
Fungal Genet. Biol.
45
1043-1052
2008
385435
Dominguez-Santos R.,Martin J.F.,Kosalkova K.,Prieto C.,Ullan R.V.,Garcia-Estrada C.
The regulatory factor PcRFX1 controls the expression of the three genes of beta-lactam biosynthesis in Penicillium chrysogenum.
Fungal Genet. Biol.
49
866-881
2012
385436
Fernandez-Aguado M.,Ullan R.V.,Teijeira F.,Rodriguez-Castro R.,Martin J.F.
The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum.
Appl. Microbiol. Biotechnol.
97
3073-3084
2013
385437
Bokhove M.,Yoshida H.,Hensgens C.M.,van der Laan J.M.,Sutherland J.D.,Dijkstra B.W.
Structures of an isopenicillin N converting Ntn-hydrolase reveal different catalytic roles for the active site residues of precursor and mature enzyme.
Structure
18
301-308
2010