Sequence of DHB1_HUMAN

3(or 17)beta-hydroxysteroid dehydrogenase

P14061

328

34950

17beta-estradiol 17-dehydrogenase

P14061

328

34950

662868

Peltoketo H.,Isomaa V.,Maeentausta O.,Vihko R.

Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.

FEBS Lett.

239

73-77

1988

662869

Luu-The V.,Labrie C.,Zhao H.F.,Couet J.,Lachance Y.,Simard J.,Leblanc G.,Labrie F.

Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta.

Mol. Endocrinol.

3

1301-1309

1989

662870

Luu-The V.,Labrie C.,Simard J.,Lachance Y.,Zhao H.F.,Couet J.,Leblanc G.,Labrie F.

Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.

Mol. Endocrinol.

4

268-275

1990

662871

Luu-The V.,Labrie C.,Zhao H.F.,Couet J.,Lachance Y.,Simard J.,Cote J.,Leblanc G.,Lagace L.,Berube D.,Gagne R.,Labrie F.

Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase.

Ann. N. Y. Acad. Sci.

595

40-52

1990

662872

Peltoketo H.E.,Isomma V.,Vihko R.

Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements.

Eur. J. Biochem.

209

459-466

1992

662874

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

662875

Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

Nature

440

1045-1049

2006

662877

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

662878

Burns D.J.W.,Engel L.L.,Bethune J.L.

Amino acid composition and subunit structure. Human placental 17 - estradiol dehydrogenase.

Biochemistry

11

2699-2703

1972

662879

Nicholas J.C.,Harris J.I.

Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine.

FEBS Lett.

29

173-176

1973

662880

Murdock G.L.,Chin C.-C.,Warren J.C.

Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region.

Biochemistry

25

641-646

1986

662881

Murdock G.L.,Chin C.C.,Offord R.E.,Bradshaw R.A.,Warren J.C.

Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione.

J. Biol. Chem.

258

11460-11464

1983

662882

Baker M.E.

Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti.

Mol. Endocrinol.

3

881-884

1989

662883

Puranen T.,Poutanen M.,Ghosh D.,Vihko P.,Vihko R.

Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis.

Mol. Endocrinol.

11

77-86

1997

662884

Ghosh D.,Pletnev V.Z.,Zhu D.W.,Wawrzak Z.,Duax W.L.,Pangborn W.,Labrie F.,Lin S.-X.

Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20-A resolution.

Structure

3

503-513

1995

662885

Azzi A.,Rehse P.H.,Zhu D.W.,Campbell R.L.,Labrie F.,Lin S.X.

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.

Nat. Struct. Biol.

3

665-668

1996

662886

Breton R.,Housset D.,Mazza C.,Fontecilla-Camps J.-C.

The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.

Structure

4

905-915

1996

662887

Mazza C.,Breton R.,Housset D.,Fontecilla-Camps J.-C.

Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.

J. Biol. Chem.

273

8145-8152

1998

662888

Sawicki M.W.,Erman M.,Puranen T.,Vihko P.,Ghosh D.

Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.

Proc. Natl. Acad. Sci. U.S.A.

96

840-845

1999

662889

Han Q.,Campbell R.L.,Gangloff A.,Huang Y.-W.,Lin S.-X.

Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.

J. Biol. Chem.

275

1105-1111

2000

662890

Qiu W.,Campbell R.L.,Gangloff A.,Dupuis P.,Boivin R.P.,Tremblay M.R.,Poirier D.,Lin S.X.

A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.

FASEB J.

16

1829-1831

2002

662891

Gangloff A.,Shi R.,Nahoum V.,Lin S.X.

Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase.

FASEB J.

17

274-276

2003

662892

Shi R.,Lin S.X.

Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.

J. Biol. Chem.

279

16778-16785

2004

662893

Normand T.,Narod S.,Labrie F.,Simard J.

Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21.

Hum. Mol. Genet.

2

479-483

1993