Sequence of MEGL_PSEPU
EC Number:4.4.1.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2-aminobut-2-enoate = 2-iminobutanoate
Other sequences found for EC No. 4.4.1.2
EC Number:4.4.1.11
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
Other sequences found for EC No. 4.4.1.11
General information:
Sequence
0 MHGSNKLPGF ATRAIHHGYD PQDHGGALVP PVYQTATFTF PTVEYGAACF AGEQAGHFYS
60 RISNPTLNLL EARMASLEGG EAGLALASGM GAITSTLWTL LRPGDEVLLG NTLYGCTFAF
120 LHHGIGEFGV KLRHVDMADL QALEAAMTPA TRVIYFESPA NPNMHMADIA GVAKIARKHG
180 ATVVVDNTYC TPYLQRPLEL GADLVVHSAT KYLSGHGDIT AGIVVGSQAL VDRIRLQGLK
240 DMTGAVLSPH DAALLMRGIK TLNLRMDRHC ANAQVLAEFL ARQPQVELIH YPGLASFPQY
300 TLARQQMSQP GGMIAFELKG GIGAGRRFMN ALQLFSRAVS LGDAESLAQH PASMTHSSYT
360 PEERAHYGIS EGLVRLSVGL EDIDDLLADV QQALKASA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
58048
Inoue H.,Sugimoto M.,Inagaki K.,Esaki N.,Soda K.,Tanaka H.
Structural analysis of the L-methionine gamma-lyase gene from Pseudomonas putida.
J. Biochem.
117
1120-1125
1995
58049
Inoue H.,Inagaki K.,Eriguchi S.I.,Tamura T.,Esaki N.,Soda K.,Tanaka H.
Molecular characterization of the mde operon involved in L-methionine catabolism of Pseudomonas putida.
J. Bacteriol.
179
3956-3962
1997
58050
Nakayama T.,Esaki N.,Tanaka H.,Soda K.
Specific labeling of the essential cysteine residue of L-methionine gamma-lyase with a cofactor analogue, N-(bromoacetyl)pyridoxamine phosphate.
Biochemistry
27
1587-1591
1988
58051
Nakayama T.,Esaki N.,Sugie K.,Beresov T.T.,Tanaka H.,Soda K.
Purification of bacterial L-methionine gamma-lyase.
Anal. Biochem.
138
421-424
1984
58052
Hoffman R.M.
Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.
Expert Opin. Biol. Ther.
15
21-31
2015
58053
Motoshima H.,Inagaki K.,Kumasaka T.,Furuichi M.,Inoue H.,Tamura T.,Esaki N.,Soda K.,Tanaka N.,Yamamoto M.,Tanaka H.
Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida.
J. Biochem.
128
349-354
2000
58056
Kudou D.,Misaki S.,Yamashita M.,Tamura T.,Takakura T.,Yoshioka T.,Yagi S.,Hoffman R.M.,Takimoto A.,Esaki N.,Inagaki K.
Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution.
J. Biochem.
141
535-544
2007
58057
Fukumoto M.,Kudou D.,Murano S.,Shiba T.,Sato D.,Tamura T.,Harada S.,Inagaki K.
The role of amino acid residues in the active site of L-methionine gamma-lyase from Pseudomonas putida.
Biosci. Biotechnol. Biochem.
76
1275-1284
2012
