Sequence of BIOA_ECOLI
EC Number:2.6.1.62
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
adenosylmethionine-8-amino-7-oxononanoate transaminase
P12995
Escherichia coli (strain K12)
429
47336
Reaction
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate
Other sequences found for EC No. 2.6.1.62
General information:
Sequence
0 MTTDDLAFDQ RHIWHPYTSM TSPLPVYPVV SAEGCELILS DGRRLVDGMS SWWAAIHGYN
60 HPQLNAAMKS QIDAMSHVMF GGITHAPAIE LCRKLVAMTP QPLECVFLAD SGSVAVEVAM
120 KMALQYWQAK GEARQRFLTF RNGYHGDTFG AMSVCDPDNS MHSLWKGYLP ENLFAPAPQS
180 RMDGEWDERD MVGFARLMAA HRHEIAAVII EPIVQGAGGM RMYHPEWLKR IRKICDREGI
240 LLIADEIATG FGRTGKLFAC EHAEIAPDIL CLGKALTGGT MTLSATLTTR EVAETISNGE
300 AGCFMHGPTF MGNPLACAAA NASLAILESG DWQQQVADIE VQLREQLAPA RDAEMVADVR
360 VLGAIGVVET THPVNMAALQ KFFVEQGVWI RPFGKLIYLM PPYIILPQQL QRLTAAVNRA
420 VQDETFFCQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
520200
Otsuka A.J.,Buoncristiani M.R.,Howard P.K.,Flamm J.,Johnson O.,Yamamoto R.,Uchida K.,Cook C.,Ruppert J.,Matsuzaki J.
The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon.
J. Biol. Chem.
263
19577-19585
1988
520202
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
520203
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
520204
Stoner G.L.,Eisenberg M.A.
Purification and properties of 7, 8-diaminopelargonic acid aminotransferase. An enzyme in the biotin biosynthetic pathway.
J. Biol. Chem.
250
4029-4036
1975
520205
Stoner G.L.,Eisenberg M.A.
Biosynthesis of 7, 8-diaminopelargonic acid from 7-keto-8-aminopelargonic acid and S-adenosyl-L-methionine. The kinetics of the reaction.
J. Biol. Chem.
250
4037-4043
1975
520206
Barker D.F.,Campbell A.M.
Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli.
J. Mol. Biol.
146
469-492
1981
520207
Mann S.,Marquet A.,Ploux O.
Inhibition of 7,8-diaminopelargonic acid aminotransferase by amiclenomycin and analogues.
Biochem. Soc. Trans.
33
802-805
2005
520208
Lin S.,Hanson R.E.,Cronan J.E.
Biotin synthesis begins by hijacking the fatty acid synthetic pathway.
Nat. Chem. Biol.
6
682-688
2010
520209
Sakaki K.,Ohishi K.,Shimizu T.,Kobayashi I.,Mori N.,Matsuda K.,Tomita T.,Watanabe H.,Tanaka K.,Kuzuyama T.,Nishiyama M.
A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.
Nat. Chem. Biol.
16
415-422
2020
520210
Kaeck H.,Sandmark J.,Gibson K.,Schneider G.,Lindqvist Y.
Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes.
J. Mol. Biol.
291
857-876
1999
520211
Eliot A.C.,Sandmark J.,Schneider G.,Kirsch J.F.
The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation.
Biochemistry
41
12582-12589
2002
520212
Sandmark J.,Mann S.,Marquet A.,Schneider G.
Structural basis for the inhibition of the biosynthesis of biotin by the antibiotic amiclenomycin.
J. Biol. Chem.
277
43352-43358
2002
520213
Sandmark J.,Eliot A.C.,Famm K.,Schneider G.,Kirsch J.F.
Conserved and nonconserved residues in the substrate binding site of 7,8-diaminopelargonic acid synthase from Escherichia coli are essential for catalysis.
Biochemistry
43
1213-1222
2004
