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Sequence of DCOR_HUMAN

EC Number:4.1.1.17

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ornithine decarboxylase
P11926
Homo sapiens
461
51148
Reaction
L-ornithine = putrescine + CO2
Other sequences found for EC No. 4.1.1.17

General information:

Sequence
show sequence in fasta format
  0 MNNFGNEEFD CHFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK KHLRWLKALP
 60 RVTPFYAVKC NDSKAIVKTL AATGTGFDCA SKTEIQLVQS LGVPPERIIY ANPCKQVSQI
120 KYAANNGVQM MTFDSEVELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLRTSRLL
180 LERAKELNID VVGVSFHVGS GCTDPETFVQ AISDARCVFD MGAEVGFSMY LLDIGGGFPG
240 SEDVKLKFEE ITGVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKIVLKEQ
300 TGSDDEDESS EQTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY YSSSIWGPTC
360 DGLDRIVERC DLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPTIYYVMS GPAWQLMQQF
420 QNPDFPPEVE EQDASTLPVS CAWESGMKRH RAACASASIN V
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
533980
Hickok N.J.,Seppaenen P.J.,Gunsalus G.L.,Jaenne O.A.
Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA.
DNA
6
179-187
1987
533982
Fitzgerald M.C.,Flanagan M.A.
Characterization and sequence analysis of the human ornithine decarboxylase gene.
DNA
8
623-634
1989
533983
van Steeg H.,van Oostrom C.T.M.,Martens J.W.M.,van Kreyl C.F.,Schepens J.,Wieringa B.
Nucleotide sequence of the human ornithine decarboxylase gene.
Nucleic Acids Res.
17
8855-8856
1989
533984
Hickok N.J.,Wahlfors J.,Crozat A.,Halmekytoe M.,Alhonen L.,Jaenne J.,Jaenne O.A.
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.
Gene
93
257-263
1990
533985
Moshier J.A.,Gilbert J.D.,Skunca M.,Dosescu J.,Almodovar K.M.,Luk G.D.
Isolation and expression of a human ornithine decarboxylase gene.
J. Biol. Chem.
265
4884-4892
1990
533986
Moshier J.A.,Osborne D.L.,Skunca M.,Dosescu J.,Gilbert J.D.,Fitzgerald M.C.,Polidori G.,Wagner R.L.,Friezner Degen S.J.,Luk G.D.,Flanagan M.A.
Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.
Nucleic Acids Res.
20
2581-2590
1992
533987
Wright P.S.,Cooper J.R.,Cross-Doersen D.E.,Miller J.A.,Chmielewski P.A.,Wagner R.L.,Streng K.A.,Flanagan M.A.
Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element.
Cell Growth Differ.
6
1097-1102
1995
533988
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
533990
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
533992
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
533993
Hsieh J.T.,Denning M.F.,Heidel S.M.,Verma A.K.
Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.
Cancer Res.
50
2239-2244
1990
533994
Kaczmarek L.,Calabretta B.,Ferrari S.,de Riel J.K.
Cell-cycle-dependent expression of human ornithine decarboxylase.
J. Cell. Physiol.
132
545-551
1987
533995
Bauer P.M.,Fukuto J.M.,Buga G.M.,Pegg A.E.,Ignarro L.J.
Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation.
Biochem. Biophys. Res. Commun.
262
355-358
1999
533996
Bauer P.M.,Buga G.M.,Fukuto J.M.,Pegg A.E.,Ignarro L.J.
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
J. Biol. Chem.
276
34458-34464
2001
533997
Leong W.F.,Chow V.T.
Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
Cell. Microbiol.
8
565-580
2006
533998
Kanerva K.,Makitie L.T.,Pelander A.,Heiskala M.,Andersson L.C.
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.
Biochem. J.
409
187-192
2008
533999
Almrud J.J.,Oliveira M.A.,Kern A.D.,Grishin N.V.,Phillips M.A.,Hackert M.L.
Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.
J. Mol. Biol.
295
7-16
2000
534000
Dufe V.T.,Ingner D.,Heby O.,Khomutov A.R.,Persson L.,Al-Karadaghi S.
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
Biochem. J.
405
261-268
2007
534001
Wu H.Y.,Chen S.F.,Hsieh J.Y.,Chou F.,Wang Y.H.,Lin W.T.,Lee P.Y.,Yu Y.J.,Lin L.Y.,Lin T.S.,Lin C.L.,Liu G.Y.,Tzeng S.R.,Hung H.C.,Chan N.L.
Structural basis of antizyme-mediated regulation of polyamine homeostasis.
Proc. Natl. Acad. Sci. U.S.A.
112
11229-11234
2015
534002
Wu D.,Kaan H.Y.,Zheng X.,Tang X.,He Y.,Vanessa Tan Q.,Zhang N.,Song H.
Structural basis of ornithine decarboxylase inactivation and accelerated degradation by polyamine sensor antizyme1.
Sci. Rep.
5
14738-14738
2015
534003
Bupp C.P.,Schultz C.R.,Uhl K.L.,Rajasekaran S.,Bachmann A.S.
Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features.
Am. J. Med. Genet. A
176
2548-2553
2018
534004
Rodan L.H.,Anyane-Yeboa K.,Chong K.,Klein Wassink-Ruiter J.S.,Wilson A.,Smith L.,Kothare S.V.,Rajabi F.,Blaser S.,Ni M.,DeBerardinis R.J.,Poduri A.,Berry G.T.
Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities.
Am. J. Med. Genet. A
176
2554-2560
2018