Sequence of ALGD_PSEAE
EC Number:1.1.1.132
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
GDP-mannose 6-dehydrogenase
P11759
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
436
47600
Reaction
GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+
Other sequences found for EC No. 1.1.1.132
General information:
Sequence
0 MRISIFGLGY VGAVCAGCLS ARGHEVIGVD VSSTKIDLIN QGKSPIVEPG LEALLQQGRQ
60 TGRLSGTTDF KKAVLDSDVS FICVGTPSKK NGDLDLGYIE TVCREIGFAI REKSERHTVV
120 VRSTVLPGTV NNVVIPLIED CSGKKAGVDF GVGTNPEFLR ESTAIKDYDF PPMTVIGELD
180 KQTGDLLEEI YRELDAPIIR KTVEVAEMIK YTCNVWHAAK VTFANEIGNI AKAVGVDGRE
240 VMDVICQDHK LNLSRYYMRP GFAFGGSCLP KDVRALTYRA SQLDVEHPML GSLMRSNSNQ
300 VQKAFDLITS HDTRKVGLLG LSFKAGTDDL RESPLVELAE MLIGKGYELR IFDRNVEYAR
360 VHGANKEYIE SKIPHVSSLL VSDLDEVVAS SDVLVLGNGD ELFVDLVNKT PSGKKLVDLV
420 GFMPHTTTAQ AEGICW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
3914
Deretic V.,Gill J.F.,Chakrabarty A.M.
Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene.
Nucleic Acids Res.
15
4567-4581
1987
3915
Stover C.K.,Pham X.-Q.T.,Erwin A.L.,Mizoguchi S.D.,Warrener P.,Hickey M.J.,Brinkman F.S.L.,Hufnagle W.O.,Kowalik D.J.,Lagrou M.,Garber R.L.,Goltry L.,Tolentino E.,Westbrock-Wadman S.,Yuan Y.,Brody L.L.,Coulter S.N.,Folger K.R.,Kas A.,Larbig K.,Lim R.M.,Smith K.A.,Spencer D.H.,Wong G.K.-S.,Wu Z.,Paulsen I.T.,Reizer J.,Saier M.H. Jr.,Hancock R.E.W.,Lory S.,Olson M.V.
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Nature
406
959-964
2000
3916
Roychoudhury S.,May T.B.,Gill J.F.,Singh S.K.,Feingold D.S.,Chakrabarty A.M.
Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa.
J. Biol. Chem.
264
9380-9385
1989
3917
Roychoudhury S.,Chakrabarty K.,Ho Y.-K.,Chakrabarty A.M.
Characterization of guanosine diphospho-D-mannose dehydrogenase from Pseudomonas aeruginosa. Structural analysis by limited proteolysis.
J. Biol. Chem.
267
990-996
1992
3918
Maharaj R.,May T.B.,Wang S.-K.,Chakrabarty A.M.
Sequence of the alg8 and alg44 genes involved in the synthesis of alginate by Pseudomonas aeruginosa.
Gene
136
267-269
1993
3919
Naught L.E.,Gilbert S.,Imhoff R.,Snook C.,Beamer L.,Tipton P.
Allosterism and cooperativity in Pseudomonas aeruginosa GDP-mannose dehydrogenase.
Biochemistry
41
9637-9645
2002
3920
Snook C.F.,Tipton P.A.,Beamer L.J.
Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa.
Biochemistry
42
4658-4668
2003
