Sequence of ODP2_HUMAN
EC Number:2.3.1.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine
Other sequences found for EC No. 2.3.1.12
General information:
Sequence
0 MWRVCARRAQ NVAPWAGLEA RWTALQEVPG TPRVTSRSGP APARRNSVTT GYGGVRALCG
60 WTPSSGATPR NRLLLQLLGS PGRRYYSLPP HQKVPLPSLS PTMQAGTIAR WEKKEGDKIN
120 EGDLIAEVET DKATVGFESL EECYMAKILV AEGTRDVPIG AIICITVGKP EDIEAFKNYT
180 LDSSAAPTPQ AAPAPTPAAT ASPPTPSAQA PGSSYPPHMQ VLLPALSPTM TMGTVQRWEK
240 KVGEKLSEGD LLAEIETDKA TIGFEVQEEG YLAKILVPEG TRDVPLGTPL CIIVEKEADI
300 SAFADYRPTE VTDLKPQVPP PTPPPVAAVP PTPQPLAPTP SAPCPATPAG PKGRVFVSPL
360 AKKLAVEKGI DLTQVKGTGP DGRITKKDID SFVPSKVAPA PAAVVPPTGP GMAPVPTGVF
420 TDIPISNIRR VIAQRLMQSK QTIPHYYLSI DVNMGEVLLV RKELNKILEG RSKISVNDFI
480 IKASALACLK VPEANSSWMD TVIRQNHVVD VSVAVSTPAG LITPIVFNAH IKGVETIAND
540 VVSLATKARE GKLQPHEFQG GTFTISNLGM FGIKNFSAII NPPQACILAI GASEDKLVPA
600 DNEKGFDVAS MMSVTLSCDH RVVDGAVGAQ WLAEFRKYLE KPITMLL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1094451
Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Nature
440
497-500
2006
1094452
Coppel R.L.,McNeilage L.J.,Surh C.D.,van de Water J.,Spithill T.W.,Whittingham S.,Gershwin M.E.
Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.
Proc. Natl. Acad. Sci. U.S.A.
85
7317-7321
1988
1094453
Thekkumkara T.J.,Ho L.,Wexler I.D.,Pon G.,Liu T.,Patel M.S.
Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex.
FEBS Lett.
240
45-48
1988
1094454
Hiromasa Y.,Fujisawa T.,Aso Y.,Roche T.E.
Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
J. Biol. Chem.
279
6921-6933
2004
1094455
Patel M.S.,Korotchkina L.G.,Sidhu S.
Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.
J. Mol. Catal., B Enzym.
61
2-6
2009
1094456
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
1094457
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1094458
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1094459
Mathias R.A.,Greco T.M.,Oberstein A.,Budayeva H.G.,Chakrabarti R.,Rowland E.A.,Kang Y.,Shenk T.,Cristea I.M.
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Cell
159
1615-1625
2014
1094460
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
1094461
Howard M.J.,Fuller C.,Broadhurst R.W.,Perham R.N.,Tang J.G.,Quinn J.,Diamond A.G.,Yeaman S.J.
Three-dimensional structure of the major autoantigen in primary biliary cirrhosis.
Gastroenterology
115
139-146
1998
1094462
Head R.A.,Brown R.M.,Zolkipli Z.,Shahdadpuri R.,King M.D.,Clayton P.T.,Brown G.K.
Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.
Ann. Neurol.
58
234-241
2005
1094463
Kato M.,Chuang J.L.,Tso S.C.,Wynn R.M.,Chuang D.T.
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.
EMBO J.
24
1763-1774
2005
1094465
Devedjiev Y.,Steussy C.N.,Vassylyev D.G.
Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.
J. Mol. Biol.
370
407-416
2007
1094466
Kato M.,Li J.,Chuang J.L.,Chuang D.T.
Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.
Structure
15
992-1004
2007
1094467
Green T.,Grigorian A.,Klyuyeva A.,Tuganova A.,Luo M.,Popov K.M.
Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2.
J. Biol. Chem.
283
15789-15798
2008
1094468
Vijayakrishnan S.,Kelly S.M.,Gilbert R.J.,Callow P.,Bhella D.,Forsyth T.,Lindsay J.G.,Byron O.
Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.
J. Mol. Biol.
399
71-93
2010
