Sequence of AROA_ECOLI
EC Number:2.5.1.19
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate
Other sequences found for EC No. 2.5.1.19
General information:
Sequence
0 MESLTLQPIA RVDGTINLPG SKSVSNRALL LAALAHGKTV LTNLLDSDDV RHMLNALTAL
60 GVSYTLSADR TRCEIIGNGG PLHAEGALEL FLGNAGTAMR PLAAALCLGS NDIVLTGEPR
120 MKERPIGHLV DALRLGGAKI TYLEQENYPP LRLQGGFTGG NVDVDGSVSS QFLTALLMTA
180 PLAPEDTVIR IKGDLVSKPY IDITLNLMKT FGVEIENQHY QQFVVKGGQS YQSPGTYLVE
240 GDASSASYFL AAAAIKGGTV KVTGIGRNSM QGDIRFADVL EKMGATICWG DDYISCTRGE
300 LNAIDMDMNH IPDAAMTIAT AALFAKGTTT LRNIYNWRVK ETDRLFAMAT ELRKVGAEVE
360 EGHDYIRITP PEKLNFAEIA TYNDHRMAMC FSLVALSDTP VTILDPKCTA KTFPDYFEQL
420 ARISQAA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
899642
Oshima T.,Aiba H.,Baba T.,Fujita K.,Hayashi K.,Honjo A.,Ikemoto K.,Inada T.,Itoh T.,Kajihara M.,Kanai K.,Kashimoto K.,Kimura S.,Kitagawa M.,Makino K.,Masuda S.,Miki T.,Mizobuchi K.,Mori H.,Motomura K.,Nakamura Y.,Nashimoto H.,Nishio Y.,Saito N.,Sampei G.,Seki Y.,Tagami H.,Takemoto K.,Wada C.,Yamamoto Y.,Yano M.,Horiuchi T.
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.
DNA Res.
3
137-155
1996
899643
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
899644
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
899646
Duncan K.,Lewendon A.,Coggins J.R.
The purification of 5-enolpyruvylshikimate 3-phosphate synthase from an overproducing strain of Escherichia coli.
FEBS Lett.
165
121-127
1984
899647
Huynh Q.K.
5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli -- the substrate analogue bromopyruvate inactivates the enzyme by modifying Cys-408 and Lys-411.
Arch. Biochem. Biophys.
284
407-412
1991
899648
Huynh Q.K.
Photo-oxidation of 5-enolpyruvoylshikimate-3-phosphate synthase from Escherichia coli: evidence for a reactive imidazole group (His385) at the herbicide glyphosate-binding site.
Biochem. J.
290
525-530
1993
899649
Stallings W.C.,Abdel-Meguid S.S.,Lim L.W.,Shieh H.-S.,Dayringer H.E.,Leimgruber N.K.,Stegeman R.A.,Anderson K.S.,Sikorski J.A.,Padgette S.R.,Kishore G.M.
Structure and topological symmetry of the glyphosate target 5-enol-pyruvylshikimate-3-phosphate synthase: a distinctive protein fold.
Proc. Natl. Acad. Sci. U.S.A.
88
5046-5050
1991
899650
Schonbrunn E.,Eschenburg S.,Shuttleworth W.A.,Schloss J.V.,Amrhein N.,Evans J.N.,Kabsch W.
Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.
Proc. Natl. Acad. Sci. U.S.A.
98
1376-1380
2001
899651
Eschenburg S.,Healy M.L.,Priestman M.A.,Lushington G.H.,Schonbrunn E.
How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coli.
Planta
216
129-135
2002
899652
Eschenburg S.,Kabsch W.,Healy M.L.,Schonbrunn E.
A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states.
J. Biol. Chem.
278
49215-49222
2003
899654
Priestman M.A.,Healy M.L.,Becker A.,Alberg D.G.,Bartlett P.A.,Lushington G.H.,Schonbrunn E.
Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail.
Biochemistry
44
3241-3248
2005
899655
Priestman M.A.,Healy M.L.,Funke T.,Becker A.,Schonbrunn E.
Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate.
FEBS Lett.
579
5773-5780
2005
899656
Funke T.,Healy-Fried M.L.,Han H.,Alberg D.G.,Bartlett P.A.,Schonbrunn E.
Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.
Biochemistry
46
13344-13351
2007
899657
Healy-Fried M.L.,Funke T.,Priestman M.A.,Han H.,Schonbrunn E.
Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J. Biol. Chem.
282
32949-32955
2007
899658
Funke T.,Yang Y.,Han H.,Healy-Fried M.,Olesen S.,Becker A.,Schonbrunn E.
Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli.
J. Biol. Chem.
284
9854-9860
2009
