Sequence of ARGI1_HUMAN
EC Number:3.5.3.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-arginine + H2O = L-ornithine + urea
Other sequences found for EC No. 3.5.3.1
General information:
Sequence
0 MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN
60 DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV
120 IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR
180 DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF
240 TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT
300 LACFGLAREG NHKPIDYLNP PK
Download this sequence
in fasta formatDownload all sequences for 3.5.3.1
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
133095
Haraguchi Y.,Takiguchi M.,Amaya Y.,Kawamoto S.,Matsuda I.,Mori M.
Molecular cloning and nucleotide sequence of cDNA for human liver arginase.
Proc. Natl. Acad. Sci. U.S.A.
84
412-415
1987
133096
Takiguchi M.,Haraguchi Y.,Mori M.
Human liver-type arginase gene: structure of the gene and analysis of the promoter region.
Nucleic Acids Res.
16
8789-8802
1988
133099
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
133100
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
133101
Ikemoto M.,Tabata M.,Miyake T.,Kono T.,Mori M.,Totani M.,Murachi T.
Expression of human liver arginase in Escherichia coli. Purification and properties of the product.
Biochem. J.
270
697-703
1990
133102
Munder M.,Mollinedo F.,Calafat J.,Canchado J.,Gil-Lamaignere C.,Fuentes J.M.,Luckner C.,Doschko G.,Soler G.,Eichmann K.,Mueller F.M.,Ho A.D.,Goerner M.,Modolell M.
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.
Blood
105
2549-2556
2005
133103
Munder M.,Schneider H.,Luckner C.,Giese T.,Langhans C.D.,Fuentes J.M.,Kropf P.,Mueller I.,Kolb A.,Modolell M.,Ho A.D.
Suppression of T-cell functions by human granulocyte arginase.
Blood
108
1627-1634
2006
133104
Oberlies J.,Watzl C.,Giese T.,Luckner C.,Kropf P.,Mueller I.,Ho A.D.,Munder M.
Regulation of NK cell function by human granulocyte arginase.
J. Immunol.
182
5259-5267
2009
133105
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
133106
Mattila J.T.,Ojo O.O.,Kepka-Lenhart D.,Marino S.,Kim J.H.,Eum S.Y.,Via L.E.,Barry C.E. III,Klein E.,Kirschner D.E.,Morris S.M. Jr.,Lin P.L.,Flynn J.L.
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.
J. Immunol.
191
773-784
2013
133107
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
133108
Monticelli L.A.,Buck M.D.,Flamar A.L.,Saenz S.A.,Tait Wojno E.D.,Yudanin N.A.,Osborne L.C.,Hepworth M.R.,Tran S.V.,Rodewald H.R.,Shah H.,Cross J.R.,Diamond J.M.,Cantu E.,Christie J.D.,Pearce E.L.,Artis D.
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nat. Immunol.
17
656-665
2016
133109
Burr M.L.,Sparbier C.E.,Chan Y.C.,Williamson J.C.,Woods K.,Beavis P.A.,Lam E.Y.N.,Henderson M.A.,Bell C.C.,Stolzenburg S.,Gilan O.,Bloor S.,Noori T.,Morgens D.W.,Bassik M.C.,Neeson P.J.,Behren A.,Darcy P.K.,Dawson S.J.,Voskoboinik I.,Trapani J.A.,Cebon J.,Lehner P.J.,Dawson M.A.
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
Nature
549
101-105
2017
133110
Di Costanzo L.,Sabio G.,Mora A.,Rodriguez P.C.,Ochoa A.C.,Centeno F.,Christianson D.W.
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.
Proc. Natl. Acad. Sci. U.S.A.
102
13058-13063
2005
133111
Di Costanzo L.,Moulin M.,Haertlein M.,Meilleur F.,Christianson D.W.
Expression, purification, assay, and crystal structure of perdeuterated human arginase I.
Arch. Biochem. Biophys.
465
82-89
2007
133112
Di Costanzo L.,Pique M.E.,Christianson D.W.
Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
J. Am. Chem. Soc.
129
6388-6389
2007
133113
Zakharian T.Y.,Di Costanzo L.,Christianson D.W.
Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.
Org. Biomol. Chem.
6
3240-3243
2008
133114
Uchino T.,Haraguchi Y.,Aparicio J.M.,Mizutani N.,Higashikawa M.,Naitoh H.,Mori M.,Matsuda I.
Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.
Am. J. Hum. Genet.
51
1406-1412
1992
133115
Grody W.W.,Klein D.,Dodson A.E.,Kern R.M.,Wissmann P.B.,Goodman B.K.,Bassand P.,Marescau B.,Kang S.-S.,Leonard J.V.,Cederbaum S.D.
Molecular genetic study of human arginase deficiency.
Am. J. Hum. Genet.
50
1281-1290
1992
133116
Uchino T.,Snyderman S.E.,Lambert M.,Qureshi I.A.,Shapira S.K.,Sansaricq C.,Smit L.M.E.,Jakobs C.,Matsuda I.
Molecular basis of phenotypic variation in patients with argininemia.
Hum. Genet.
96
255-260
1995
133117
Carvalho D.R.,Brand G.D.,Brum J.M.,Takata R.I.,Speck-Martins C.E.,Pratesi R.
Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes.
Gene
509
124-130
2012
133118
Wu T.F.,Liu Y.P.,Li X.Y.,Wang Q.,Ding Y.,Ma Y.Y.,Song J.Q.,Yang Y.L.
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
Pediatr. Neurol.
49
119-123
2013
