Sequence of OAT_HUMAN
EC Number:2.6.1.13
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-ornithine + a 2-oxo carboxylate = L-glutamate 5-semialdehyde + an L-amino acid
Other sequences found for EC No. 2.6.1.13
General information:
Sequence
0 MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY GAHNYHPLPV
60 ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA LKSQVDKLTL TSRAFYNNVL
120 GEYEEYITKL FNYHKVLPMN TGVEAGETAC KLARKWGYTV KGIQKYKAKI VFAAGNFWGR
180 TLSAISSSTD PTSYDGFGPF MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV
240 PDPGYLMGVR ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP
300 VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD KLGIILRNEL
360 MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN GLLAKPTHGD IIRFAPPLVI
420 KEDELRESIE IINKTILSF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
580026
Inana G.,Totsuka S.,Redmond M.,Dougherty T.,Nagle J.,Shiono T.,Ohura T.,Kominami E.,Katunuma N.
Molecular cloning of human ornithine aminotransferase mRNA.
Proc. Natl. Acad. Sci. U.S.A.
83
1203-1207
1986
580027
Ramesh V.,Shaffer M.M.,Allaire J.M.,Shih V.E.,Gusella J.F.
Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase.
DNA
5
493-501
1986
580028
Kobayashi T.,Nishii M.,Takagi Y.,Titani T.,Matsuzawa T.
Molecular cloning and nucleotide sequence analysis of mRNA for human kidney ornithine aminotransferase. An examination of ornithine aminotransferase isozymes between liver and kidney.
FEBS Lett.
255
300-304
1989
580029
Mitchell G.A.,Looney J.E.,Brody L.C.,Steel G.,Suchanek M.,Engelhardt J.F.,Willard H.F.,Valle D.
Human ornithine-delta-aminotransferase. cDNA cloning and analysis of the structural gene.
J. Biol. Chem.
263
14288-14295
1988
580030
Zintz C.B.,Inana G.
Analysis of the human ornithine aminotransferase gene family.
Exp. Eye Res.
50
759-770
1990
580031
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
580033
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
580034
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
580036
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
580037
Ramesh V.,Gusella J.F.,Shih V.E.
Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency.
Mol. Biol. Med.
8
81-93
1991
580038
Simmaco M.,John R.A.,Barra D.,Bossa F.
The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis.
FEBS Lett.
199
39-42
1986
580039
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
580040
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
580041
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
580042
Shah S.A.,Shen B.W.,Brunger A.T.
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.
Structure
5
1067-1075
1997
580043
Shen B.W.,Hennig M.,Hohenester E.,Jansonius J.N.,Schirmer T.
Crystal structure of human recombinant ornithine aminotransferase.
J. Mol. Biol.
277
81-102
1998
580044
Storici P.,Capitani G.,Mueller R.,Schirmer T.,Jansonius J.N.
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.
J. Mol. Biol.
285
297-309
1999
580045
Ramesh V.,McClatchey A.I.,Ramesh N.,Benoit L.A.,Berson E.L.,Shih V.E.,Gusella J.F.
Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy.
Proc. Natl. Acad. Sci. U.S.A.
85
3777-3780
1988
580046
Inana G.,Chambers C.,Hotta Y.,Inouye L.,Filpula D.,Pulford S.,Shiono T.
Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy.
J. Biol. Chem.
264
17432-17436
1989
580047
Michaud J.,Brody L.C.,Steel G.,Fontaine G.,Martin L.S.,Valle D.,Mitchell G.
Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene.
Genomics
13
389-394
1992
580048
Brody L.C.,Mitchell G.A.,Obie C.,Michaud J.,Steel G.,Fontaine G.,Robert M.-F.,Sipila I.,Kaiser-Kupfer M.,Valle D.
Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences.
J. Biol. Chem.
267
3302-3307
1992
580049
Michaud J.,Thompson G.N.,Brody L.C.,Steel G.,Obie C.,Fontaine G.,Schappert K.,Keith C.G.,Valle D.,Mitchell G.A.
Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V.
Am. J. Hum. Genet.
56
616-622
1995
580050
Kobayashi T.,Ogawa H.,Kasahara M.,Shiozawa Z.,Matsuzawa T.
A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor.
Am. J. Hum. Genet.
57
284-291
1995
580051
Doimo M.,Desbats M.A.,Baldoin M.C.,Lenzini E.,Basso G.,Murphy E.,Graziano C.,Seri M.,Burlina A.,Sartori G.,Trevisson E.,Salviati L.
Functional analysis of missense mutations of OAT, causing gyrate atrophy of choroid and retina.
Hum. Mutat.
34
229-236
2013
