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Sequence of DAPB_ECOLI

EC Number:1.17.1.8

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
4-hydroxy-tetrahydrodipicolinate reductase
P04036
Escherichia coli (strain K12)
273
28757
Reaction
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
Other sequences found for EC No. 1.17.1.8

EC Number:1.17.1.8

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
4-hydroxy-tetrahydrodipicolinate reductase
P04036
Escherichia coli (strain K12)
273
28757
Reaction
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
Other sequences found for EC No. 1.17.1.8

General information:

Sequence
show sequence in fasta format
  0 MHDANIRVAI AGAGGRMGRQ LIQAALALEG VQLGAALERE GSSLLGSDAG ELAGAGKTGV
 60 TVQSSLDAVK DDFDVFIDFT RPEGTLNHLA FCRQHGKGMV IGTTGFDEAG KQAIRDAAAD
120 IAIVFAANFS VGVNVMLKLL EKAAKVMGDY TDIEIIEAHH RHKVDAPSGT ALAMGEAIAH
180 ALDKDLKDCA VYSREGHTGE RVPGTIGFAT VRAGDIVGEH TAMFADIGER LEITHKASSR
240 MTFANGAVRS ALWLSGKESG LFDMRDVLDL NNL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
533356
Bouvier J.,Richaud C.,Richaud F.,Patte J.-C.,Stragier P.
Nucleotide sequence and expression of the Escherichia coli dapB gene.
J. Biol. Chem.
259
14829-14834
1984
533357
Yura T.,Mori H.,Nagai H.,Nagata T.,Ishihama A.,Fujita N.,Isono K.,Mizobuchi K.,Nakata A.
Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.
Nucleic Acids Res.
20
3305-3308
1992
533358
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
533359
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
533360
Bouvier J.,Patte J.-C.,Stragier P.
Multiple regulatory signals in the control region of the Escherichia coli carAB operon.
Proc. Natl. Acad. Sci. U.S.A.
81
4139-4143
1984
533361
Reddy S.G.,Sacchettini J.C.,Blanchard J.S.
Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase.
Biochemistry
34
3492-3501
1995
533362
Bouvier J.,Stragier P.,Morales V.,Remy E.,Gutierrez C.
Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator.
J. Bacteriol.
190
5224-5229
2008
533363
Devenish S.R.,Blunt J.W.,Gerrard J.A.
NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase.
J. Med. Chem.
53
4808-4812
2010
533364
Scapin G.,Blanchard J.S.,Sacchettini J.C.
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry
34
3502-3512
1995
533365
Reddy S.G.,Scapin G.,Blanchard J.S.
Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes.
Biochemistry
35
13294-13302
1996
533366
Scapin G.,Reddy S.G.,Zheng R.,Blanchard J.S.
Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
Biochemistry
36
15081-15088
1997