Sequence of CARB_ECOLI
EC Number:6.3.5.5
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
carbamoyl-phosphate synthase (glutamine-hydrolysing)
P00968
Escherichia coli (strain K12)
1073
117842
Reaction
2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Other sequences found for EC No. 6.3.5.5
General information:
Sequence
0 MPKRTDIKSI LILGAGPIVI GQACEFDYSG AQACKALREE GYRVILVNSN PATIMTDPEM
60 ADATYIEPIH WEVVRKIIEK ERPDAVLPTM GGQTALNCAL ELERQGVLEE FGVTMIGATA
120 DAIDKAEDRR RFDVAMKKIG LETARSGIAH TMEEALAVAA DVGFPCIIRP SFTMGGSGGG
180 IAYNREEFEE ICARGLDLSP TKELLIDESL IGWKEYEMEV VRDKNDNCII VCSIENFDAM
240 GIHTGDSITV APAQTLTDKE YQIMRNASMA VLREIGVETG GSNVQFAVNP KNGRLIVIEM
300 NPRVSRSSAL ASKATGFPIA KVAAKLAVGY TLDELMNDIT GGRTPASFEP SIDYVVTKIP
360 RFNFEKFAGA NDRLTTQMKS VGEVMAIGRT QQESLQKALR GLEVGATGFD PKVSLDDPEA
420 LTKIRRELKD AGADRIWYIA DAFRAGLSVD GVFNLTNIDR WFLVQIEELV RLEEKVAEVG
480 ITGLNADFLR QLKRKGFADA RLAKLAGVRE AEIRKLRDQY DLHPVYKRVD TCAAEFATDT
540 AYMYSTYEEE CEANPSTDRE KIMVLGGGPN RIGQGIEFDY CCVHASLALR EDGYETIMVN
600 CNPETVSTDY DTSDRLYFEP VTLEDVLEIV RIEKPKGVIV QYGGQTPLKL ARALEAAGVP
660 VIGTSPDAID RAEDRERFQH AVERLKLKQP ANATVTAIEM AVEKAKEIGY PLVVRPSYVL
720 GGRAMEIVYD EADLRRYFQT AVSVSNDAPV LLDHFLDDAV EVDVDAICDG EMVLIGGIME
780 HIEQAGVHSG DSACSLPAYT LSQEIQDVMR QQVQKLAFEL QVRGLMNVQF AVKNNEVYLI
840 EVNPRAARTV PFVSKATGVP LAKVAARVMA GKSLAEQGVT KEVIPPYYSV KEVVLPFNKF
900 PGVDPLLGPE MRSTGEVMGV GRTFAEAFAK AQLGSNSTMK KHGRALLSVR EGDKERVVDL
960 AAKLLKQGFE LDATHGTAIV LGEAGINPRL VNKVHEGRPH IQDRIKNGEY TYIINTTSGR
1020 RAIEDSRVIR RSALQYKVHY DTTLNGGFAT AMALNADATE KVISVQEMHA QIK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
522926
Nyunoya H.,Lusty C.J.
The carB gene of Escherichia coli: a duplicated gene coding for the large subunit of carbamoyl-phosphate synthetase.
Proc. Natl. Acad. Sci. U.S.A.
80
4629-4633
1983
522927
Bouvier J.,Patte J.-C.,Stragier P.
Multiple regulatory signals in the control region of the Escherichia coli carAB operon.
Proc. Natl. Acad. Sci. U.S.A.
81
4139-4143
1984
522928
Yura T.,Mori H.,Nagai H.,Nagata T.,Ishihama A.,Fujita N.,Isono K.,Mizobuchi K.,Nakata A.
Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.
Nucleic Acids Res.
20
3305-3308
1992
522929
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
522930
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
522931
Piette J.,Nyunoya H.,Lusty C.J.,Cunin R.,Weyens G.,Crabeel M.,Charlier D.R.M.,Glansdorff N.,Pierard A.
DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.
Proc. Natl. Acad. Sci. U.S.A.
81
4134-4138
1984
522932
VanBogelen R.A.,Abshire K.Z.,Moldover B.,Olson E.R.,Neidhardt F.C.
Escherichia coli proteome analysis using the gene-protein database.
Electrophoresis
18
1243-1251
1997
522933
Thoden J.B.,Holden H.M.,Wesenberg G.,Raushel F.M.,Rayment I.
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.
Biochemistry
36
6305-6316
1997
522934
Thoden J.B.,Miran S.G.,Phillips J.C.,Howard A.J.,Raushel F.M.,Holden H.M.
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.
Biochemistry
37
8825-8831
1998
522935
Thoden J.B.,Raushel F.M.,Benning M.M.,Rayment I.,Holden H.M.
The structure of carbamoyl phosphate synthetase determined to 2.1-A resolution.
Acta Crystallogr. D
55
8-24
1999
522936
Thoden J.B.,Wesenberg G.,Raushel F.M.,Holden H.M.
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry
38
2347-2357
1999
522937
Thoden J.B.,Huang X.,Raushel F.M.,Holden H.M.
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry
38
16158-16166
1999
522938
Thoden J.B.,Raushel F.M.,Wesenberg G.,Holden H.M.
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
J. Biol. Chem.
274
22502-22507
1999
