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Sequence of TRPA_SALTY

EC Number:4.2.1.20

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
tryptophan synthase
P00929
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
268
28671
Reaction
1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Other sequences found for EC No. 4.2.1.20

General information:

Sequence
show sequence in fasta format
  0 MERYENLFAQ LNDRREGAFV PFVTLGDPGI EQSLKIIDTL IDAGADALEL GVPFSDPLAD
 60 GPTIQNANLR AFAAGVTPAQ CFEMLALIRE KHPTIPIGLL MYANLVFNNG IDAFYARCEQ
120 VGVDSVLVAD VPVEESAPFR QAALRHNIAP IFICPPNADD DLLRQVASYG RGYTYLLSRS
180 GVTGAENRGA LPLHHLIEKL KEYHAAPALQ GFGISSPEQV SAAVRAGAAG AISGSAIVKI
240 IEKNLASPKQ MLAELRSFVS AMKAASRA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1267365
Nichols B.P.,Yanofsky C.
Nucleotide sequences of trpA of Salmonella typhimurium and Escherichia coli: an evolutionary comparison.
Proc. Natl. Acad. Sci. U.S.A.
76
5244-5248
1979
1267366
Schneider W.P.,Nichols B.P.,Yanofsky C.
Procedure for production of hybrid genes and proteins and its use in assessing significance of amino acid differences in homologous tryptophan synthetase alpha polypeptides.
Proc. Natl. Acad. Sci. U.S.A.
78
2169-2173
1981
1267367
McClelland M.,Sanderson K.E.,Spieth J.,Clifton S.W.,Latreille P.,Courtney L.,Porwollik S.,Ali J.,Dante M.,Du F.,Hou S.,Layman D.,Leonard S.,Nguyen C.,Scott K.,Holmes A.,Grewal N.,Mulvaney E.,Ryan E.,Sun H.,Florea L.,Miller W.,Stoneking T.,Nhan M.,Waterston R.,Wilson R.K.
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
Nature
413
852-856
2001
1267368
Li S.-L.,Yanofsky C.
Amino acid sequence studies with the tryptophan synthetase alpha chain of Salmonella typhimurium.
J. Biol. Chem.
248
1830-1836
1973
1267369
Hyde C.C.,Ahmed S.A.,Padlan E.A.,Miles E.W.,Davies D.R.
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.
J. Biol. Chem.
263
17857-17871
1988
1267370
Rhee S.,Parris K.D.,Hyde C.C.,Ahmed S.A.,Miles E.W.,Davies D.R.
Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes.
Biochemistry
36
7664-7680
1997
1267371
Rhee S.,Miles E.W.,Davies D.R.
Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49.
J. Biol. Chem.
273
8553-8555
1998
1267373
Sachpatzidis A.,Dealwis C.,Lubetsky J.B.,Liang P.-H.,Anderson K.S.,Lolis E.
Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.
Biochemistry
38
12665-12674
1999
1267374
Weyand M.,Schlichting I.
Structural basis for the impaired channeling and allosteric inter-subunit communication in the beta A169L/beta C170W mutant of tryptophan synthase.
J. Biol. Chem.
275
41058-41063
2000
1267375
Kulik V.,Weyand M.,Seidel R.,Niks D.,Arac D.,Dunn M.F.,Schlichting I.
On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase.
J. Mol. Biol.
324
677-690
2002