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Sequence of PNPH_HUMAN

EC Number:2.4.2.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.4.2.1
purine-nucleoside phosphorylase
P00491
Homo sapiens
289
32118
Swiss-Prot
Reaction
purine 2'-deoxyribonucleoside + phosphate = purine + 2-deoxy-alpha-D-ribose 1-phosphate
Other sequences found for EC No. 2.4.2.1

General information:

Sequence
show sequence in fasta format
  0 MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST
 60 VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL
120 NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ
180 MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL
240 ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1231159
Williams S.R.,Goddard J.M.,Martin D.W. Jr.
Human purine nucleoside phosphorylase cDNA sequence and genomic clone characterization.
Nucleic Acids Res.
12
5779-5787
1984
6087295
1231160
Williams S.R.,Gekeler V.,McIvor R.S.,Martin D.W. Jr.
A human purine nucleoside phosphorylase deficiency caused by a single base change.
J. Biol. Chem.
262
2332-2338
1987
3029074
1231161
Yu L.,Kalla K.,Guthrie E.,Vidrine A.,Klimecki W.T.
Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans.
Environ. Health Perspect.
111
1421-1427
2003
12928150
1231162
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
14702039
1231165
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
1231167
Stoeckler J.D.,Poirot A.F.,Smith R.M.,Parks R.E. Jr.,Ealick S.E.,Takabayashi K.,Erion M.D.
Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis.
Biochemistry
36
11749-11756
1997
9305964
1231168
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
19413330
1231169
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
21269460
1231170
Bienvenut W.V.,Sumpton D.,Martinez A.,Lilla S.,Espagne C.,Meinnel T.,Giglione C.
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
Mol. Cell. Proteomics
11
0-0
2012
22223895
1231171
von Lohneysen K.,Scott T.M.,Soldau K.,Xu X.,Friedman J.S.
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
PLoS ONE
7
0-0
2012
22509282
1231172
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
23186163
1231173
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
24275569
1231174
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
25944712
1231175
Ealick S.E.,Rule S.A.,Carter D.C.,Greenhough T.J.,Babu Y.S.,Cook W.J.,Habash J.,Helliwell J.R.,Stoeckler J.D.,Parks R.E. Jr.,Chen S.-F.,Bugg C.E.
Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2-A resolution.
J. Biol. Chem.
265
1812-1820
1990
2104852
1231176
Ealick S.E.,Babu Y.S.,Bugg C.E.,Erion M.D.,Guida W.C.,Montgomery J.A.,Secrist J.A.
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc. Natl. Acad. Sci. U.S.A.
88
11540-11544
1991
1763067
1231177
Canduri F.,dos Santos D.M.,Silva R.G.,Mendes M.A.,Basso L.A.,Palma M.S.,de Azevedo W.F.,Santos D.S.
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI.
Biochem. Biophys. Res. Commun.
313
907-914
2004
14706628
1231178
Suarez J.,Haapalainen A.M.,Cahill S.M.,Ho M.C.,Yan F.,Almo S.C.,Schramm V.L.
Catalytic site conformations in human PNP by 19F-NMR and crystallography.
Chem. Biol.
20
212-222
2013
23438750
1231179
Aust M.R.,Andrews L.G.,Barrett M.J.,Norby-Slycord C.J.,Markert M.L.
Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency.
Am. J. Hum. Genet.
51
763-772
1992
1384322
1231180
Pannicke U.,Tuchschmid P.,Friedrich W.,Bartram C.R.,Schwarz K.
Two novel missense and frameshift mutations in exons 5 and 6 of the purine nucleoside phosphorylase (PNP) gene in a severe combined immunodeficiency (SCID) patient.
Hum. Genet.
98
706-709
1996
8931706