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Sequence of DHE3_HUMAN

EC Number:1.4.1.3

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
glutamate dehydrogenase [NAD(P)+]
P00367
Homo sapiens
558
61398
Reaction
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
Other sequences found for EC No. 1.4.1.3

General information:

Sequence
show sequence in fasta format
  0 MYRYLGEALL LSRAGPAALG SASADSAALL GWARGQPAAA PQPGLALAAR RHYSEAVADR
 60 EDDPNFFKMV EGFFDRGASI VEDKLVEDLR TRESEEQKRN RVRGILRIIK PCNHVLSLSF
120 PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG
180 GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY
240 ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG
300 DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG
360 FPKAKPYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER
420 NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK
480 HGGTIPIVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV
540 NAIEKVFKVY NEAGVTFT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
25315
Nakatani Y.,Banner C.,von Herrat M.,Schneider M.E.,Smith H.H.,Freese E.
Comparison of human brain and liver glutamate dehydrogenase cDNAs.
Biochem. Biophys. Res. Commun.
149
405-410
1987
25316
Amuro N.,Yamaura M.,Goto Y.,Okazaki T.
Molecular cloning and nucleotide sequence of the cDNA for human liver glutamate dehydrogenase precursor.
Biochem. Biophys. Res. Commun.
152
1395-1400
1988
25317
Nakatani Y.,Schneider M.E.,Banner C.,Freese E.
Complete nucleotide sequence of human glutamate dehydrogenase cDNA.
Nucleic Acids Res.
16
6237-6237
1988
25318
Mavrothalassitis G.,Tzimagiorgis G.,Mitsialis A.,Zannis V.,Plaitakis A.,Papamatheakis J.,Moschonas N.
Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family.
Proc. Natl. Acad. Sci. U.S.A.
85
3494-3498
1988
25319
Michaelidis T.M.,Tzimagiorgis G.,Moschonas N.K.,Papamatheakis J.
The human glutamate dehydrogenase gene family: gene organization and structural characterization.
Genomics
16
150-160
1993
25320
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
25321
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
25323
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
25324
Julliard J.H.,Smith E.L.
Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme.
J. Biol. Chem.
254
3427-3438
1979
25325
Hochstrasser D.F.,Frutiger S.,Paquet N.,Bairoch A.,Ravier F.,Pasquali C.,Sanchez J.-C.,Tissot J.-D.,Bjellqvist B.,Vargas R.,Appel R.D.,Hughes G.J.
Human liver protein map: a reference database established by microsequencing and gel comparison.
Electrophoresis
13
992-1001
1992
25326
Banner C.,Silverman S.,Thomas J.W.,Lampel K.A.,Vitkovic L.,Huie D.,Wenthold R.J.
Isolation of a human brain cDNA for glutamate dehydrogenase.
J. Neurochem.
49
246-252
1987
25328
Tzimagiorgis G.,Leversha M.A.,Chroniary K.,Goulielmos G.,Sargent C.A.,Ferguson-Smith M.,Moschonas N.K.
Structure and expression analysis of a member of the human glutamate dehydrogenase (GLUD) gene family mapped to chromosome 10p11.2.
Hum. Genet.
91
433-438
1993
25329
Plaitakis A.,Metaxari M.,Shashidharan P.
Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.
J. Neurochem.
75
1862-1869
2000
25330
Choi M.M.,Huh J.W.,Yang S.J.,Cho E.H.,Choi S.Y.,Cho S.W.
Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes.
FEBS Lett.
579
4125-4130
2005
25331
Mastorodemos V.,Kotzamani D.,Zaganas I.,Arianoglou G.,Latsoudis H.,Plaitakis A.
Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.
Biochem. Cell Biol.
87
505-516
2009
25332
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
25333
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
25334
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
25335
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
25336
Smith T.J.,Peterson P.E.,Schmidt T.,Fang J.,Stanley C.A.
Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation.
J. Mol. Biol.
307
707-720
2001
25337
Fang J.,Hsu B.Y.L.,MacMullen C.M.,Poncz M.,Smith T.J.,Stanley C.A.
Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations.
Biochem. J.
363
81-87
2002
25338
Haigis M.C.,Mostoslavsky R.,Haigis K.M.,Fahie K.,Christodoulou D.C.,Murphy A.J.,Valenzuela D.M.,Yancopoulos G.D.,Karow M.,Blander G.,Wolberger C.,Prolla T.A.,Weindruch R.,Alt F.W.,Guarente L.
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Cell
126
941-954
2006
25339
Huang H.,Luo Z.,Qi S.,Huang J.,Xu P.,Wang X.,Gao L.,Li F.,Wang J.,Zhao W.,Gu W.,Chen Z.,Dai L.,Dai J.,Zhao Y.
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.
Cell Res.
28
111-125
2018
25340
Smith T.J.,Schmidt T.,Fang J.,Wu J.,Siuzdak G.,Stanley C.A.
The structure of apo human glutamate dehydrogenase details subunit communication and allostery.
J. Mol. Biol.
318
765-777
2002
25341
Banerjee S.,Schmidt T.,Fang J.,Stanley C.A.,Smith T.J.
Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation.
Biochemistry
42
3446-3456
2003
25342
Stanley C.A.,Lieu Y.K.,Hsu B.Y.L.,Burlina A.B.,Greenberg C.R.,Hopwood N.J.,Perlman K.,Rich B.H.,Zammarchi E.,Poncz M.
Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.
N. Engl. J. Med.
338
1352-1357
1998
25343
Miki Y.,Taki T.,Ohura T.,Kato H.,Yanagisawa M.,Hayashi Y.
Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome.
J. Pediatr.
136
69-72
2000
25344
Santer R.,Kinner M.,Passarge M.,Superti-Furga A.,Mayatepek E.,Meissner T.,Schneppenheim R.,Schaub J.
Novel missense mutations outside the allosteric domain of glutamate dehydrogenase are prevalent in European patients with the congenital hyperinsulinism-hyperammonemia syndrome.
Hum. Genet.
108
66-71
2001
25345
MacMullen C.,Fang J.,Hsu B.Y.L.,Kelly A.,de Lonlay-Debeney P.,Saudubray J.-M.,Ganguly A.,Smith T.J.,Stanley C.A.,Brown R.,Buist N.,Dasouki M.,Fefferman R.,Grange D.,Karaviti L.,Luedke C.,Marriage B.,McLaughlin J.,Perlman K.,Seashore M.,van Vliet G.
Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase.
J. Clin. Endocrinol. Metab.
86
1782-1787
2001