Sequence of KMO_RAT
EC Number:1.14.13.9
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O
Other sequences found for EC No. 1.14.13.9
General information:
Sequence
0 MASSDTEGKR VVVIGGGLVG ALNACFLAKR NFQVDVYEAR EDIRVANFMR GRSINLALSY
60 RGRQALKAVG LEDQIVSKGV PMKARMIHSL SGKKSAIPYG NKSQYILSIS REKLNKDLLT
120 AVESYPNAKV HFGHKLSKCC PEEGILTMLG PNKVPRDITC DLIVGCDGAY STVRAHLMKK
180 PRFDYSQQYI PHGYMELTIP PKNGEYAMEP NCLHIWPRNA FMMIALPNMD KSFTCTLFMS
240 FEEFEKLPTH SDVLDFFQKN FPDAIPLMGE QALMRDFFLL PAQPMISVKC SPFHLKSRCV
300 LMGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFNNDLSV CLPEFSRFRI PDDHAISDLS
360 MYNYIEMRAH VNSRWFLFQR LLDKFLHALM PSTFIPLYTM VAFTRIRYHE AVLRWHWQKK
420 VINRGLFVLG SLVAIGSAYI LVHHLSPRPL ELLRSAWTGT SGHWNRSADI SPRVPWSH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
435370
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
435371
Erickson J.B.,Flanagan E.M.,Russo S.,Reinhard J.F. Jr.
A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine.
Anal. Biochem.
205
257-262
1992
435372
Stone T.W.,Darlington L.G.
Endogenous kynurenines as targets for drug discovery and development.
Nat. Rev. Drug Discov.
1
609-620
2002
435373
Mole D.J.,Webster S.P.,Uings I.,Zheng X.,Binnie M.,Wilson K.,Hutchinson J.P.,Mirguet O.,Walker A.,Beaufils B.,Ancellin N.,Trottet L.,Beneton V.,Mowat C.G.,Wilkinson M.,Rowland P.,Haslam C.,McBride A.,Homer N.Z.,Baily J.E.,Sharp M.G.,Garden O.J.,Hughes J.,Howie S.E.,Holmes D.S.,Liddle J.,Iredale J.P.
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Nat. Med.
22
202-209
2016
435374
Walker A.L.,Ancellin N.,Beaufils B.,Bergeal M.,Binnie M.,Bouillot A.,Clapham D.,Denis A.,Haslam C.P.,Holmes D.S.,Hutchinson J.P.,Liddle J.,McBride A.,Mirguet O.,Mowat C.G.,Rowland P.,Tiberghien N.,Trottet L.,Uings I.,Webster S.P.,Zheng X.,Mole D.J.
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J. Med. Chem.
60
3383-3404
2017
