Sequence of O68183_ENTCA
EC Number:2.7.1.190
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
GTP + gentamicin = GDP + gentamicin 2''-phosphate
Other sequences found for EC No. 2.7.1.190
General information:
Sequence
0 MRTYTFDQVE KAIEQLYPDF TINTIEISGE GNDCIAYEIN RDFIFKFPKH SRGSTNLFNE
60 VNILKRIHNK LPLPIPEVVF TGMPSETYQM SFAGFTKIKG VPLTPLLLNN LPKQSQNQAA
120 KDLARFLSEL HSINISGFKS NLVLDFREKI NEDNKKIKKL LSRELKGPQM KKVDDFYRDI
180 LENEIYFKYY PCLIHNDFSS DHILFDTEKN TICGIIDFGD AAISDPDNDF ISLMEDDEEY
240 GMEFVSKILN HYKHKDIPTV LEKYRMKEKY WSFEKIIYGK EYGYMDWYEE GLNEIRSIKI
300 K
Download this sequence
in fasta formatDownload all sequences for 2.7.1.190
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
30685086
Tsai S.F.,Zervos M.J.,Clewell D.B.,Donabedian S.M.,Sahm D.F.,Chow J.W.
A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp.
Antimicrob. Agents Chemother.
42
1229-1232
1998
30685087
Toth M.,Frase H.,Antunes N.T.,Smith C.A.,Vakulenko S.B.
Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2''-IVa.
Protein Sci.
19
1565-1576
2010
30685088
Shi K.,Houston D.R.,Berghuis A.M.
Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases.
Biochemistry
50
6237-6244
2011
30685089
Shakya T.,Stogios P.J.,Waglechner N.,Evdokimova E.,Ejim L.,Blanchard J.E.,McArthur A.G.,Savchenko A.,Wright G.D.
A small molecule discrimination map of the antibiotic resistance kinome.
Chem. Biol.
18
1591-1601
2011
30685090
Shi K.,Berghuis A.M.
Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases.
J. Biol. Chem.
287
13094-13102
2012
30685092
Kaplan E.,Guichou J.F.,Chaloin L.,Kunzelmann S.,Leban N.,Serpersu E.H.,Lionne C.
Aminoglycoside binding and catalysis specificity of aminoglycoside 2-phosphotransferase IVa: A thermodynamic, structural and kinetic study.
Biochim. Biophys. Acta
1860
802-813
2016
30685093
Cox G.,Ejim L.,Stogios P.J.,Koteva K.,Bordeleau E.,Evdokimova E.,Sieron A.O.,Savchenko A.,Serio A.W.,Krause K.M.,Wright G.D.
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
ACS Infect. Dis.
4
980-987
2018
