Sequence of P85B_HUMAN

phosphatidylinositol 3-kinase

O00459

728

81545

836916

Volinia S.,Patracchini P.,Otsu M.,Hiles I.,Gout I.,Calzolari E.,Bernardi F.,Rooke L.,Waterfield M.D.

Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.

Oncogene

7

789-793

1992

836917

Janssen J.W.G.,Schleithhoff L.,Bartram C.R.,Schulz A.S.

An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.

Oncogene

16

1767-1772

1998

836918

Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.

The DNA sequence and biology of human chromosome 19.

Nature

428

529-535

2004

836919

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

836920

Braunger J.,Schleithoff L.,Schulz A.S.,Kessler H.,Lammers R.,Ullrich A.,Bartram C.R.,Janssen J.W.

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

Oncogene

14

2619-2631

1997

836921

Igarashi K.,Isohara T.,Kato T.,Shigeta K.,Yamano T.,Uno I.

Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

Biochem. Biophys. Res. Commun.

246

95-99

1998

836922

Wang J.F.,Zhang X.,Groopman J.E.

Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

J. Biol. Chem.

279

27088-27097

2004

836923

Tsuboi N.,Utsunomiya T.,Roberts R.L.,Ito H.,Takahashi K.,Noda M.,Takahashi T.

The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase.

Biochem. J.

413

193-200

2008

836924

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

836925

Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.

Large-scale proteomics analysis of the human kinome.

Mol. Cell. Proteomics

8

1751-1764

2009

836926

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

836927

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

836928

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

836929

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

836930

Kuchay S.,Duan S.,Schenkein E.,Peschiaroli A.,Saraf A.,Florens L.,Washburn M.P.,Pagano M.

FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade.

Nat. Cell Biol.

15

472-480

2013

836931

Nakamura K.,Kato M.,Tohyama J.,Shiohama T.,Hayasaka K.,Nishiyama K.,Kodera H.,Nakashima M.,Tsurusaki Y.,Miyake N.,Matsumoto N.,Saitsu H.

AKT3 and PIK3R2 mutations in two patients with megalencephaly-related syndromes: MCAP and MPPH.

Clin. Genet.

85

396-398

2014

836932

Riviere J.B.,Mirzaa G.M.,O'Roak B.J.,Beddaoui M.,Alcantara D.,Conway R.L.,St-Onge J.,Schwartzentruber J.A.,Gripp K.W.,Nikkel S.M.,Worthylake T.,Sullivan C.T.,Ward T.R.,Butler H.E.,Kramer N.A.,Albrecht B.,Armour C.M.,Armstrong L.,Caluseriu O.,Cytrynbaum C.,Drolet B.A.,Innes A.M.,Lauzon J.L.,Lin A.E.,Mancini G.M.,Meschino W.S.,Reggin J.D.,Saggar A.K.,Lerman-Sagie T.,Uyanik G.,Weksberg R.,Zirn B.,Beaulieu C.L.,Majewski J.,Bulman D.E.,O'Driscoll M.,Shendure J.,Graham J.M. Jr.,Boycott K.M.,Dobyns W.B.

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.

Nat. Genet.

44

934-940

2012

836933

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

836934

Lu Y.,Zheng X.,Hu W.,Bian S.,Zhang Z.,Tao D.,Liu Y.,Ma Y.

Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

Oncotarget

8

54913-54924

2017

836935

Mirzaa G.M.,Conti V.,Timms A.E.,Smyser C.D.,Ahmed S.,Carter M.,Barnett S.,Hufnagel R.B.,Goldstein A.,Narumi-Kishimoto Y.,Olds C.,Collins S.,Johnston K.,Deleuze J.F.,Nitschke P.,Friend K.,Harris C.,Goetsch A.,Martin B.,Boyle E.A.,Parrini E.,Mei D.,Tattini L.,Slavotinek A.,Blair E.,Barnett C.,Shendure J.,Chelly J.,Dobyns W.B.,Guerrini R.

Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study.

Lancet Neurol.

14

1182-1195

2015

836936

Terrone G.,Voisin N.,Abdullah Alfaiz A.,Cappuccio G.,Vitiello G.,Guex N.,D'Amico A.,James Barkovich A.,Brunetti-Pierri N.,Del Giudice E.,Reymond A.

De novo PIK3R2 variant causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia.

Eur. J. Hum. Genet.

24

1359-1362

2016