Sequence of PK3CD_HUMAN
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MPPGVDCPME FWTKEENQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQLLW HRAQYEPLFH
60 MLSGPEAYVF TCINQTAEQQ ELEDEQRRLC DVQPFLPVLR LVAREGDRVK KLINSQISLL
120 IGKGLHEFDS LCDPEVNDFR AKMCQFCEEA AARRQQLGWE AWLQYSFPLQ LEPSAQTWGP
180 GTLRLPNRAL LVNVKFEGSE ESFTFQVSTK DVPLALMACA LRKKATVFRQ PLVEQPEDYT
240 LQVNGRHEYL YGSYPLCQFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
300 AKPPPIPAKK PSSVSLWSLE QPFRIELIQG SKVNADERMK LVVQAGLFHG NEMLCKTVSS
360 SEVSVCSEPV WKQRLEFDIN ICDLPRMARL CFALYAVIEK AKKARSTKKK SKKADCPIAW
420 ANLMLFDYKD QLKTGERCLY MWPSVPDEKG ELLNPTGTVR SNPNTDSAAA LLICLPEVAP
480 HPVYYPALEK ILELGRHSEC VHVTEEEQLQ LREILERRGS GELYEHEKDL VWKLRHEVQE
540 HFPEALARLL LVTKWNKHED VAQMLYLLCS WPELPVLSAL ELLDFSFPDC HVGSFAIKSL
600 RKLTDDELFQ YLLQLVQVLK YESYLDCELT KFLLDRALAN RKIGHFLFWH LRSEMHVPSV
660 ALRFGLILEA YCRGSTHHMK VLMKQGEALS KLKALNDFVK LSSQKTPKPQ TKELMHLCMR
720 QEAYLEALSH LQSPLDPSTL LAEVCVEQCT FMDSKMKPLW IMYSNEEAGS GGSVGIIFKN
780 GDDLRQDMLT LQMIQLMDVL WKQEGLDLRM TPYGCLPTGD RTGLIEVVLR SDTIANIQLN
840 KSNMAATAAF NKDALLNWLK SKNPGEALDR AIEEFTLSCA GYCVATYVLG IGDRHSDNIM
900 IRESGQLFHI DFGHFLGNFK TKFGINRERV PFILTYDFVH VIQQGKTNNS EKFERFRGYC
960 ERAYTILRRH GLLFLHLFAL MRAAGLPELS CSKDIQYLKD SLALGKTEEE ALKHFRVKFN
1020 EALRESWKTK VNWLAHNVSK DNRQ
Download this sequence
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in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205822
Vanhaesebroeck B.A.M.,Welham M.J.,Kotani K.,Stein R.,Warne P.H.,Zvelebil M.J.,Higashi K.,Volinia S.,Downward J.,Waterfield M.D.
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
Proc. Natl. Acad. Sci. U.S.A.
94
4330-4335
1997
205824
Chantry D.,Vojtek A.,Kashishian A.,Holtzman D.A.,Wood C.,Gray P.W.,Cooper J.A.,Hoekstra M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
J. Biol. Chem.
272
19236-19241
1997
205825
Fransson S.,Uv A.,Eriksson H.,Andersson M.K.,Wettergren Y.,Bergo M.,Ejeskar K.
p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors.
Oncogene
31
3277-3286
2012
205827
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
205828
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
205829
Meier T.I.,Cook J.A.,Thomas J.E.,Radding J.A.,Horn C.,Lingaraj T.,Smith M.C.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.
Protein Expr. Purif.
35
218-224
2004
205830
Vanhaesebroeck B.,Higashi K.,Raven C.,Welham M.,Anderson S.,Brennan P.,Ward S.G.,Waterfield M.D.
Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.
EMBO J.
18
1292-1302
1999
205831
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
205832
Soond D.R.,Bjorgo E.,Moltu K.,Dale V.Q.,Patton D.T.,Torgersen K.M.,Galleway F.,Twomey B.,Clark J.,Gaston J.S.H.,Tasken K.,Bunyard P.,Okkenhaug K.
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.
Blood
115
2203-2213
2010
205833
Rommel C.,Camps M.,Ji H.
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Nat. Rev. Immunol.
7
191-201
2007
205834
Fung-Leung W.-P.
Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function.
Cell. Signal.
23
603-608
2011
205835
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
205836
Angulo I.,Vadas O.,Garcon F.,Banham-Hall E.,Plagnol V.,Leahy T.R.,Baxendale H.,Coulter T.,Curtis J.,Wu C.,Blake-Palmer K.,Perisic O.,Smyth D.,Maes M.,Fiddler C.,Juss J.,Cilliers D.,Markelj G.,Chandra A.,Farmer G.,Kielkowska A.,Clark J.,Kracker S.,Debre M.,Picard C.,Pellier I.,Jabado N.,Morris J.A.,Barcenas-Morales G.,Fischer A.,Stephens L.,Hawkins P.,Barrett J.C.,Abinun M.,Clatworthy M.,Durandy A.,Doffinger R.,Chilvers E.R.,Cant A.J.,Kumararatne D.,Okkenhaug K.,Williams R.L.,Condliffe A.,Nejentsev S.
Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage.
Science
342
866-871
2013
205837
Sharfe N.,Karanxha A.,Dadi H.,Merico D.,Chitayat D.,Herbrick J.A.,Freeman S.,Grinstein S.,Roifman C.M.
Dual loss of p110delta PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features.
J. Allergy Clin. Immunol.
142
618-629
2018
205838
Sogkas G.,Fedchenko M.,Dhingra A.,Jablonka A.,Schmidt R.E.,Atschekzei F.
Primary immunodeficiency disorder caused by phosphoinositide 3-kinase delta deficiency.
J. Allergy Clin. Immunol.
142
1650-1653
2018
205839
Cohen S.B.,Bainter W.,Johnson J.L.,Lin T.Y.,Wong J.C.Y.,Wallace J.G.,Jones J.,Qureshi S.,Mir F.,Qamar F.,Cantley L.C.,Geha R.S.,Chou J.
Human primary immunodeficiency caused by expression of a kinase-dead p110delta mutant.
J. Allergy Clin. Immunol.
143
797-799
2019
